{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:31:38Z","timestamp":1777480298339,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CBM"],"published-print":{"date-parts":[[2021,2,22]]},"abstract":"<jats:p>BACKGROUND: Circular RNA (circRNA) is a class of non-coding RNA that is vital for regulating gene expression and biological functions. Mounting studies demonstrate that circRNA is crucial for human cancer development. However, the role of circ_0000039 in gastric cancer (GC) remains uncertain. METHODS: Normal human gastric tissues and GC tissue samples were collected, and quantitative real-time polymerase chain reaction (qRT-PCR) was employed to detect the expression levels of circ_0000039, miR-1292-5p, and DEK. GC cell lines with overexpression and low expression of circ_0000039 were constructed. Cell counting kit-8 (CCK-8), scratch healing and Transwell experiments were used to assess the function of circ_0000039 on the proliferation, migration and invasion of GC cells. Bioinformatics analysis and dual-luciferase reporter assays were employed to detect the targeting relationship between circ_0000039 and miR-1292-5p. RESULTS: Circ_0000039 expression was up-regulated in GC tissues and cell lines, and it was significantly related with poor differentiation of tumor tissues. In addition, circ_0000039 overexpression enhanced the proliferation, migration and invasion of GC cells, while circ_0000039 depletion inhibited these malignant biological behaviors. In terms of mechanism, it was found that circ_0000039 promoted the proliferation and progression of GC cells by adsorbing miR-1292-5p and up-regulating the expression of DEK. CONCLUSION: Circ_0000039 is a new oncogenic circRNA in GC, which regulates the miR-1292-5p\/DEK axis to modulate the malignant biological behaviors of GC.<\/jats:p>","DOI":"10.3233\/cbm-201754","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T10:49:25Z","timestamp":1603190965000},"page":"167-177","source":"Crossref","is-referenced-by-count":16,"title":["Circular RNA circ_0000039 enhances gastric cancer progression through miR-1292-5p\/DEK axis"],"prefix":"10.1177","volume":"30","author":[{"given":"Dengguo","family":"Fan","sequence":"first","affiliation":[{"name":"Department of General Surgery, Caoxian People\u2019s Hospital, Heze, Shandong 274400, China"},{"name":"Department of General Surgery, Caoxian People\u2019s Hospital, Heze, Shandong 274400, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changjiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Caoxian People\u2019s Hospital, Heze, Shandong 274400, China"},{"name":"Department of General Surgery, Caoxian People\u2019s Hospital, Heze, Shandong 274400, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Caoxian People\u2019s Hospital, Heze, Shandong 274400, China"},{"name":"Department of General Surgery, Caoxian People\u2019s Hospital, Heze, Shandong 274400, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Caoxian County Hospital of Shandong Province, Heze, Shandong 274400, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Caoxian People\u2019s Hospital, Heze, Shandong 274400, 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Huang et al., DEK is a potential biomarker associated with malignant phenotype in gastric cancer tissues and plasma, Int J Mol Sci 20(22) (2019).","DOI":"10.3390\/ijms20225689"},{"key":"10.3233\/CBM-201754_ref41","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1746-1596-9-67","article-title":"High expression of DEK predicts poor prognosis of gastric adenocarcinoma","volume":"9","author":"Piao","year":"2014","journal-title":"Diagn Pathol"}],"container-title":["Cancer Biomarkers"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/CBM-201754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:08:04Z","timestamp":1777385284000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/CBM-201754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,22]]},"references-count":41,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/cbm-201754","relation":{},"ISSN":["1875-8592","1574-0153"],"issn-type":[{"value":"1875-8592","type":"electronic"},{"value":"1574-0153","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2,22]]}}}