{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:31:58Z","timestamp":1777480318574,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CBM"],"published-print":{"date-parts":[[2021,5,17]]},"abstract":"<jats:p>BACKGROUND: CPNEs are significant biomarkers which can affect the progression and prognosis of various tumor diseases. However, the prognosis role of CPNEs in multiple myeloma (MM) is still unclear. OBJECTIVES: To investigate the prognosis role of CPNEs in MM. METHODS: Seven hundred and thirty-five samples from two independent data sets were involved to analyze the clinical and molecular characteristics, and prognosis role of the expression of CPNE1-9 in MM. RESULTS: MM patients with higher expressions of CPNE5 and CPNE9 had longer event-free survival (EFS) and overall survival (OS) compared with CPNE5low and CPNE9low expression groups (EFS: P= 0.0054, 0.0065; OS: P= 0.015, 0.016, respectively). Multivariate regression analysis showed that CPNE5 was an independent favorable predictor for EFS and OS (EFS: P= 0.005; OS: P= 0.006), and CPNE9 was an independent positive indicator for EFS (P= 0.002). Moreover, the survival probability and the cumulative event of EFS and OS in CPNE5highCPNE9high group were significantly longer than other groups. CONCLUSIONS: High expressions of CPNE5 and CPNE9 might be used as positive indicators for MM, and their combination was a better predictor for the survival of MM patients.<\/jats:p>","DOI":"10.3233\/cbm-203108","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T13:36:52Z","timestamp":1616765812000},"page":"77-85","source":"Crossref","is-referenced-by-count":4,"title":["High expression of CPNE5 and CPNE9 predicts positive prognosis in multiple myeloma"],"prefix":"10.1177","volume":"31","author":[{"given":"Pei","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Hematology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China"},{"name":"Translational Medicine Center, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China"},{"name":"Guangdong Provincial Education Department Key Laboratory of Nano-Immunoregulation Tumor Microenvironment, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China"},{"name":"Department of Hematology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China"},{"name":"Translational Medicine Center, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China"},{"name":"Guangdong Provincial Education Department Key Laboratory of Nano-Immunoregulation Tumor Microenvironment, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China"},{"name":"Department of Hematology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaozeng","family":"Si","sequence":"additional","affiliation":[{"name":"Information Center, China-Japan Friendship Hospital, Beijing, China"},{"name":"Department of Hematology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Translational Medicine Center, Huaihe Hospital of Henan University, Kaifeng, Henan, China"},{"name":"Department of Hematology, Huaihe Hospital of Henan University, Kaifeng, Henan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longzhen","family":"Cui","sequence":"additional","affiliation":[{"name":"Translational Medicine Center, Huaihe Hospital of Henan University, Kaifeng, Henan, China"},{"name":"Department of Hematology, Huaihe Hospital of Henan University, Kaifeng, Henan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China"},{"name":"Translational Medicine Center, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China"},{"name":"Guangdong Provincial Education Department Key Laboratory of Nano-Immunoregulation Tumor Microenvironment, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China"},{"name":"Translational Medicine Center, State Key Laboratory of Respiratory Disease, The Second Affiliated 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system","volume":"80","author":"Bataille","year":"1992","journal-title":"Blood"},{"key":"10.3233\/CBM-203108_ref35","doi-asserted-by":"crossref","unstructured":"J. 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