{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T16:56:34Z","timestamp":1779900994348,"version":"3.53.1"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CBM"],"published-print":{"date-parts":[[2022,4,6]]},"abstract":"<jats:p>BACKGROUND: The disorder of LINC01207 has a significant regulatory effect on cancers, nevertheless its role in non-small cell lung cancer (NSCLC) have not been illustrated. This study investigated the regulatory effect of LINC01207 on NSCLC and clarify its molecular mechanism. METHODS: Bioinformatics analysis was used to find the target lncRNA, miRNA and mRNA. LncBase and TargetScan databases predicted the relationship between LINC01207, miR-525-5p and ARHGAP11A. Dual-luciferase reporter gene assay and RNA binding protein immunoprecipitation assay were used to verify the binding relationship between genes. Fluorescence in situ hybridization assay was used to localize the expression of LINC01207 in NSCLC tissue. qRT-PCR and Western blot assays were used to measure the expression of LINC01207, miR-525-5p and ARHGAP11A. CCK-8 assay, Transwell assay and flow cytometry assay were used to detect NSCLC cell abilities. Mouse xenograft models further determined the effect of LINC01207 on the growth of NSCLC in vivo. RESULTS: LINC01207 was up-regulated in NSCLC tissue and cells, which was mainly localized in the cytoplasm. LINC01207 knockdown could inhibit the proliferation, migration and invasion of cancer cells and induce cell apoptosis. In addition, silencing LINC01207 could suppress tumor growth in vivo. LINC01207 could sponge and inhibit the expression of miR-525-5p in NSCLC cells, and inhibiting LINC01207 and miR-525-5p simultaneously could reverse the effect of miR-525-5p on the progression of NSCLC cells. Further study on downstream target genes showed that miR-525-5p could restrain the expression of ARHGAP11A, and then affect the progression of NSCLC. LINC01207 acting as a competing endogenous RNA (ceRNA) could regulate the expression of ARHGAP11A by competitively binding with miR-525-5p. CONCLUSION: LINC01207 regulates the progression of NSCLC by regulating the miR-525-5p\/ARHGAP11A axis as a ceRNA and plays a carcinogenic role. In conclusion, our study elucidates the mechanism of LINC01207 regulating the progression of NSCLC, and provides a new idea for the diagnosis and treatment of NSCLC guided by lncRNA.<\/jats:p>","DOI":"10.3233\/cbm-203197","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T14:03:06Z","timestamp":1630418586000},"page":"401-414","source":"Crossref","is-referenced-by-count":10,"title":["LINC01207 promotes the progression of non-small cell lung cancer via regulating ARHGAP11A by sponging miR-525-5p"],"prefix":"10.1177","volume":"33","author":[{"given":"Bin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Key Laboratory of Respiratory Disease of Zhejiang Province, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Key Laboratory of Respiratory Disease of Zhejiang Province, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"},{"name":"Department of Respiration, Hospital of Traditional Chinese Medicine of Zhenhai, Ningbo, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Key Laboratory of Respiratory Disease of Zhejiang Province, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"issue":"6","key":"10.3233\/CBM-203197_ref1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"issue":"10066","key":"10.3233\/CBM-203197_ref2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0140-6736(16)30958-8","article-title":"Lung cancer: current therapies and new targeted treatments","volume":"389","author":"Hirsch","year":"2017","journal-title":"Lancet"},{"issue":"8","key":"10.3233\/CBM-203197_ref3","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrc3775","article-title":"Non-small-cell lung cancers: a heterogeneous set of diseases","volume":"14","author":"Chen","year":"2014","journal-title":"Nat Rev Cancer"},{"issue":"9","key":"10.3233\/CBM-203197_ref4","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41419-019-1840-6","article-title":"Regulating autophagy facilitated therapeutic efficacy of the sonic Hedgehog pathway inhibition on lung adenocarcinoma through GLI2 suppression and ROS production","volume":"10","author":"Fan","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.3233\/CBM-203197_ref5","doi-asserted-by":"crossref","first-page":"8045","DOI":"10.2147\/OTT.S178431","article-title":"Potential clinical application of lncRNAs in non-small cell lung cancer","volume":"11","author":"Lu","year":"2018","journal-title":"Onco Targets Ther"},{"issue":"3","key":"10.3233\/CBM-203197_ref6","first-page":"1509","article-title":"Long noncoding RNA BCYRN1 promotes glycolysis and tumor progression by regulating the miR149\/PKM2 axis in nonsmallcell lung cancer","volume":"21","author":"Lang","year":"2020","journal-title":"Mol Med Rep"},{"issue":"2","key":"10.3233\/CBM-203197_ref7","first-page":"895","article-title":"Long noncoding RNA LINC01296 induces non-small cell lung cancer growth and progression through sponging miR-5095","volume":"11","author":"Hu","year":"2019","journal-title":"Am J Transl Res"},{"key":"10.3233\/CBM-203197_ref8","doi-asserted-by":"crossref","first-page":"109858","DOI":"10.1016\/j.biopha.2020.109858","article-title":"Long non-coding RNA LINC00525 promotes the non-small cell lung cancer progression by targeting miR-338-3p\/IRS2 axis","volume":"124","author":"Yang","year":"2020","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"10.3233\/CBM-203197_ref9","doi-asserted-by":"crossref","DOI":"10.1177\/1010428317697574","article-title":"Increased HAGLR expression promotes non-small cell lung cancer proliferation and invasion via enhanced de novo lipogenesis","volume":"39","author":"Lu","year":"2017","journal-title":"Tumour Biol"},{"key":"10.3233\/CBM-203197_ref10","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.biopha.2018.06.073","article-title":"Long noncoding RNA HOXD-AS1 promotes non-small cell lung cancer migration and invasion through regulating miR-133b\/MMP9 axis","volume":"106","author":"Xia","year":"2018","journal-title":"Biomed Pharmacother"},{"issue":"10","key":"10.3233\/CBM-203197_ref11","first-page":"3162","article-title":"The long noncoding RNA LINC01207 promotes proliferation of lung adenocarcinoma","volume":"5","author":"Wang","year":"2015","journal-title":"Am J Cancer Res"},{"key":"10.3233\/CBM-203197_ref12","doi-asserted-by":"crossref","first-page":"110424","DOI":"10.1016\/j.mce.2019.04.004","article-title":"Long non-coding RNA LINC01207 silencing suppresses AGR2 expression to facilitate autophagy and apoptosis of pancreatic cancer cells by sponging miR-143-5p","volume":"493","author":"Liu","year":"2019","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"10.3233\/CBM-203197_ref13","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/s13046-018-0921-1","article-title":"Long non-coding RNA DANCR promotes malignant phenotypes of bladder cancer cells by modulating the miR-149\/MSI2 axis as a ceRNA","volume":"37","author":"Zhan","year":"2018","journal-title":"J Exp Clin Cancer Res"},{"issue":"5","key":"10.3233\/CBM-203197_ref14","first-page":"1558","article-title":"ALK inhibitors and cranial radiotherapy in brain metastasis from NSCLC","volume":"23","author":"Benderli Cihan","year":"2018","journal-title":"J BUON"},{"issue":"Pt 1","key":"10.3233\/CBM-203197_ref15","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.semcancer.2017.11.019","article-title":"Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy","volume":"52","author":"Osmani","year":"2018","journal-title":"Semin Cancer Biol"},{"issue":"3","key":"10.3233\/CBM-203197_ref16","first-page":"1233","article-title":"LncRNA TRERNA1 promotes malignant progression of NSCLC through targeting FOXL1","volume":"24","author":"Luo","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"18","key":"10.3233\/CBM-203197_ref17","doi-asserted-by":"crossref","first-page":"7830","DOI":"10.18632\/aging.102291","article-title":"Downregulation of LncRNA-XIST inhibited development of non-small cell lung cancer by activating miR-335\/SOD2\/ROS signal pathway mediated pyroptotic cell death","volume":"11","author":"Liu","year":"2019","journal-title":"Aging (Albany NY)"},{"issue":"12","key":"10.3233\/CBM-203197_ref18","doi-asserted-by":"crossref","first-page":"4548","DOI":"10.1002\/jcb.26116","article-title":"lncRNA CCAT1 Promotes Glioma Tumorigenesis by Sponging miR-181b","volume":"118","author":"Cui","year":"2017","journal-title":"Journal of cellular biochemistry"},{"issue":"5","key":"10.3233\/CBM-203197_ref19","first-page":"4168","article-title":"lncRNA PTAR promotes NSCLC cell proliferation, migration and invasion by sponging microRNA101","volume":"20","author":"Yu","year":"2019","journal-title":"Mol Med Rep"},{"key":"10.3233\/CBM-203197_ref20","doi-asserted-by":"crossref","first-page":"109309","DOI":"10.1016\/j.biopha.2019.109309","article-title":"LncRNA FENDRR suppresses the progression of NSCLC via regulating miR-761\/TIMP2 axis","volume":"118","author":"Zhang","year":"2019","journal-title":"Biomed Pharmacother"},{"issue":"8","key":"10.3233\/CBM-203197_ref21","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1007\/s10620-019-05916-9","article-title":"MiR-525-5p Repressed Metastasis and Anoikis Resistance in Cervical Cancer via Blocking UBE2C\/ZEB1\/2 Signal Axis","volume":"65","author":"Chen","year":"2020","journal-title":"Dig Dis Sci"},{"issue":"4","key":"10.3233\/CBM-203197_ref22","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3233\/CBM-160598","article-title":"New miRNA expression abnormalities in laryngeal squamous cell carcinoma","volume":"16","author":"Cybula","year":"2016","journal-title":"Cancer Biomark"},{"issue":"4","key":"10.3233\/CBM-203197_ref23","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1080\/21541248.2016.1220350","article-title":"Filling GAPs in our knowledge: ARHGAP11A and RACGAP1 act as oncogenes in basal-like breast cancers","volume":"9","author":"Lawson","year":"2018","journal-title":"Small GTPases"},{"issue":"1","key":"10.3233\/CBM-203197_ref24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12964-018-0312-4","article-title":"Blockade of ARHGAP11A reverses malignant progress via inactivating Rac1B in hepatocellular carcinoma","volume":"16","author":"Dai","year":"2018","journal-title":"Cell Commun Signal"},{"issue":"1","key":"10.3233\/CBM-203197_ref25","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1186\/s12967-018-1732-z","article-title":"Integrated analysis of dysregulated long non-coding RNAs\/microRNAs\/mRNAs in metastasis of lung adenocarcinoma","volume":"16","author":"Li","year":"2018","journal-title":"J Transl Med"}],"container-title":["Cancer Biomarkers"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/CBM-203197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:08:29Z","timestamp":1777385309000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/CBM-203197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,6]]},"references-count":25,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3233\/cbm-203197","relation":{},"ISSN":["1875-8592","1574-0153"],"issn-type":[{"value":"1875-8592","type":"electronic"},{"value":"1574-0153","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4,6]]}}}