{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:36:37Z","timestamp":1777480597462,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CBM"],"published-print":{"date-parts":[[2022,7,18]]},"abstract":"<jats:p>BACKGROUND: The inflammatory markers are associated with adverse clinical outcomes in endometrial cancers (EC), but hematopoietic aging may affect the results. OBJECTIVE: To compare inflammatory markers in geriatric and nongeriatric EC. METHODS: This study included 342 women with endometrial cancers (n: 171) and age-matched controls (n: 171). Geriatric (\u2a7e 65 years old) and nongeriatric women in each group was compared for inflammatory markers, neutrophil\/lymphocyte ratio (NLR), platelet\/lymphocyte ratio (PLR), mean platelet volume (MPV), and platelet distribution width (PDW). RESULTS: Geriatric EC had more common nonendometrioid tumors, myometrial invasion, lymph node metastasis, advanced stage, and low overall survival (OS). Nongeriatric EC had low MPV, high NLR, and PDW compared to nongeriatric control. Geriatric EC had low MPV, lymphocyte, and high NLR, PLR compared to geriatric control (p&lt; 0.05). Geriatric EC had significantly low PDW and high NLR, PLR compared to nongeriatric EC in early stages, not in advanced stages. Lymphocyte count was significantly low in geriatric EC with all stages (p&lt; 0.05). In nongeriatric EC, stage was related to platelet count (r: 0.341, p: 0.0019), and PLR (r: 0.252, p: 0.01). OS was negatively related to PLR (r: -0.267, p: 0.007) and NLR (r: -0.353, p: 0.000). In geriatric EC, myometrium invasion was negatively related to lymphocyte count (r: -0.268, p: 0.035). OS was related to neutrophil count (p: 0.352, p: 0.01). MPV was negatively related to stage (r: -0.335, p: 0.01) and OS (r: -0.337, p: 0.02). CONCLUSIONS: The inflammatory responses of geriatric and nongeriatric EC were different in the early and advanced stages. Geriatric EC had low PDW and high NLR, PLR compared to nongeriatric EC in early stages. Decreased lymphocyte count was the most prominent feature of geriatric EC in the early and advanced stages. These results suggested that decreased lymphocyte count may reflect an aggressive course of disease in the elderlies. Future inflammation studies may direct anticancer treatment strategies in geriatric EC. Further research on inflammaging and geriatric EC is needed to increase our understanding of aging and carcinogenesis.<\/jats:p>","DOI":"10.3233\/cbm-210215","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T10:48:31Z","timestamp":1650019711000},"page":"583-590","source":"Crossref","is-referenced-by-count":3,"title":["The comparison of inflammatory markers in geriatric and nongeriatric endometrial cancers"],"prefix":"10.1177","volume":"34","author":[{"given":"Fisun","family":"Vural","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Department, University of Health Sciences, Hamidiye Medical Faculty, Haydarpa\u015fa Numune Training and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015fe Deniz Ert\u00fcrk","family":"Co\u015fkun","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, University of Health Sciences, Hamidiye Medical Faculty, Haydarpa\u015fa Numune Training and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ksu","family":"\u00c7\u0131tak","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, University of Health Sciences, Hamidiye Medical Faculty, Haydarpa\u015fa Numune Training and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birol","family":"Vural","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, \u015ei\u015fli Kolan International Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcltekin","family":"K\u00f6se","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, University of Health Sciences, Hamidiye Medical Faculty, Haydarpa\u015fa Numune Training and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/CBM-210215_ref1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/AOG.0b013e3182605bf1","article-title":"Endometrial cancer","volume":"120","author":"Sorosky","year":"2012","journal-title":"Obstetrics and Gynecology"},{"key":"10.3233\/CBM-210215_ref2","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1097\/01.AOG.0000462977.61229.de","article-title":"149: Endometrial cancer","volume":"125","author":"Practice Bulletin","year":"2015","journal-title":"Obstetrics and Gynecology"},{"key":"10.3233\/CBM-210215_ref3","first-page":"468","article-title":"Diagnosis and management of endometrial cancer","volume":"93","author":"Braun","year":"2016","journal-title":"American Family Physician"},{"key":"10.3233\/CBM-210215_ref4","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.2217\/fon.14.192","article-title":"USA endometrial cancer projections to 2030: Should we be concerned","volume":"10","author":"Sheikh","year":"2014","journal-title":"Future Oncology"},{"key":"10.3233\/CBM-210215_ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jnci\/dju124","article-title":"Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: A systematic review and meta-analysis","volume":"106","author":"Templeton","year":"2014","journal-title":"Journal of National Cancer Institute"},{"key":"10.3233\/CBM-210215_ref6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.suronc.2013.12.001","article-title":"A systematic review and meta-analysis on the impact of pre-operative neutrophil lymphocyte ratio on long term outcomes after curative intent resection of solid tumours","volume":"23","author":"Paramanathan","year":"2014","journal-title":"Surgical Oncology"},{"key":"10.3233\/CBM-210215_ref7","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s13277-011-0285-z","article-title":"Comparison of the prognostic value of various preoperative inflammation-based factors in patients with stage III gastric cancer","volume":"33","author":"Wang","year":"2012","journal-title":"Tumor Biology"},{"key":"10.3233\/CBM-210215_ref8","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2217\/fon.09.136","article-title":"Role of systemic inflammatory response in predicting survival in patients with primary operable cancer","volume":"6","author":"Roxburgh","year":"2010","journal-title":"Future Oncology"},{"key":"10.3233\/CBM-210215_ref9","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/clpt.2011.122","article-title":"Use of inflammatory markers to guide cancer treatment","volume":"90","author":"Clarke","year":"2011","journal-title":"Clinical Pharmacology & Therapeutics"},{"key":"10.3233\/CBM-210215_ref10","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0140-6736(00)04046-0","article-title":"Inflammation and cancer: Back to Virchow","volume":"357","author":"Balkwill","year":"2001","journal-title":"Lancet"},{"key":"10.3233\/CBM-210215_ref11","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nri3899","article-title":"Bacteria, inflammation and cancer","volume":"15","author":"Pollard","year":"2015","journal-title":"Nature Reviews Immunology"},{"key":"10.3233\/CBM-210215_ref12","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: The next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.3233\/CBM-210215_ref13","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s13670-014-0088-3","article-title":"Endometrial cancer in the elderly","volume":"3","author":"MacKenzie","year":"2014","journal-title":"Current Geriatrics Reports"},{"key":"10.3233\/CBM-210215_ref14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ijgo.2009.02.012","article-title":"Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium","volume":"105","author":"Pecorelli","year":"2009","journal-title":"International Journal of Gynecology & Obstetrics"},{"key":"10.3233\/CBM-210215_ref15","doi-asserted-by":"crossref","unstructured":"N. Colombo, C. Creutzberg, F. Amant, T. Bosse, A. Gonz\u00e1 lez-Mart\u00edn, J. Ledermann, C. Marth, R. Nouth, D. Querleu, M.R. Mirza, C. Sessa and ESMO-ESGO-ESTRO Endometrial Consensus Conference Working Group, ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: Diagnosis, treatment and follow-up, Annals of Oncology 1 (2016), 16\u201341.","DOI":"10.1093\/annonc\/mdv484"},{"key":"10.3233\/CBM-210215_ref16","first-page":"53","article-title":"Considerations for successful cancer immunotherapy in aged hosts","volume":"1","author":"Hurez","year":"2017","journal-title":"Clinical and Experimental Immunology"},{"key":"10.3233\/CBM-210215_ref17","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ccr.2009.06.017","article-title":"Polarization of tumor-associated neutrophil phenotype by TGF-beta: \u201cN1\u201d versus \u201cN2\u201d TAN","volume":"16","author":"Fridlender","year":"2009","journal-title":"Cancer Cell"},{"key":"10.3233\/CBM-210215_ref18","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.semcancer.2013.02.001","article-title":"Immunomonitoring and prognostic relevance of neutrophils in clinical trials","volume":"23","author":"Donskov","year":"2013","journal-title":"Seminars in Cancer Biology"},{"key":"10.3233\/CBM-210215_ref19","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"10.3233\/CBM-210215_ref20","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/sji.12413","article-title":"Effects of ageing on the immune system: Infants to elderly","volume":"4","author":"Valiathan","year":"2016","journal-title":"Scandinavian Journal of Immunology"},{"key":"10.3233\/CBM-210215_ref21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/3758068","article-title":"Neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume-to-platelet count ratio as biomarkers in critically ill and injured patients: Which ratio to choose to predict outcome and nature of bacteremia","volume":"3758068","author":"Djordjevic","year":"2018","journal-title":"Mediators of Inflammation"},{"key":"10.3233\/CBM-210215_ref22","doi-asserted-by":"crossref","first-page":"287","DOI":"10.4149\/BLL_2020_045","article-title":"Value of neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio and red blood cell distribution width in distinguishing between reactive lymphadenopathy and lymphoma in children","volume":"4","author":"Tezol","year":"2020","journal-title":"Bratislava Medical Journal"},{"key":"10.3233\/CBM-210215_ref23","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.ygyno.2017.02.026","article-title":"Is the neutrophil-to-lymphocyte ratio prognostic of survival outcomes in gynecologic cancers? A systematic review and meta-analysis","volume":"145","author":"Ethier","year":"2017","journal-title":"Gynecologic Oncology"},{"key":"10.3233\/CBM-210215_ref24","first-page":"337","article-title":"Pre-treatment neutrophil to lymphocyte ratio is a predictor of prognosis in endometrial cancer","volume":"35","author":"Haruma","year":"2015","journal-title":"Anticancer Research"},{"key":"10.3233\/CBM-210215_ref25","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ejogrb.2018.05.028","article-title":"Prognostic value of pre-operative neutrophil\/lymphocyte ratio, monocyte count, mean platelet volume, and platelet\/lymphocyte ratio in endometrial cancer","volume":"226","author":"Temur","year":"2018","journal-title":"European Journal of Obstetrics, Gynecology, and Reproductive Biology"},{"key":"10.3233\/CBM-210215_ref26","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/bjc.2015.200","article-title":"Preoperative neutrophil: Lymphocyte and platelet: Lymphocyte ratios predict endometrial cancer survival","volume":"113","author":"Cummings","year":"2015","journal-title":"British Journal of Cancer"},{"key":"10.3233\/CBM-210215_ref27","doi-asserted-by":"crossref","unstructured":"R. Cong, F. Kong, J. Ma, Q. Li, Q. Wu and X. Ma, Combination of preoperative neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and monocyte-lymphocyte ratio: A superior prognostic factor of endometrial cancer, BMC Cancer 20 (2020), 464.","DOI":"10.1186\/s12885-020-06953-8"},{"key":"10.3233\/CBM-210215_ref28","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/ijgo.12230","article-title":"Retrospective study of the prognostic significance of neutrophil-to-lymphocyte ratio for postsurgical outcomes of patients with endometrial carcinoma","volume":"138","author":"Ding","year":"2017","journal-title":"International Journal of Gynaecolgy & Obstetrics"},{"key":"10.3233\/CBM-210215_ref29","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s00404-019-05257-y","article-title":"Platelet-lymphocyte ratio as potential prognostic factor in gynecologic cancers: A meta-analysis","volume":"300","author":"Jiang","year":"2019","journal-title":"Archives of Gynecology and Obstetrics"},{"key":"10.3233\/CBM-210215_ref30","doi-asserted-by":"crossref","first-page":"78","DOI":"10.4274\/jtgga.2017.0112","article-title":"Independent predictors of survival in endometrium cancer: Platelet-to-lymphocyte ratio and platelet\/neutrophil\/monocyte-to-lymphocyte ratio","volume":"19","author":"Comert","year":"2018","journal-title":"Journal of the Turkish German Gynecological Association"},{"key":"10.3233\/CBM-210215_ref31","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00404-019-05372-w","article-title":"Prognostic values of pretreatment neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in endometrial cancer: A systematic review and meta-analysis","volume":"301","author":"Ni","year":"2020","journal-title":"Archives of Gynecology& Obstetrics"},{"key":"10.3233\/CBM-210215_ref32","first-page":"359","article-title":"Pre-treatment thrombocytosis predicts prognosis of endometrial cancer: A meta-analysis of 11 studies","volume":"19","author":"Ye","year":"2020","journal-title":"Experimental and Therapeutic Medicine"},{"key":"10.3233\/CBM-210215_ref33","doi-asserted-by":"crossref","first-page":"10231","DOI":"10.7314\/APJCP.2014.15.23.10231","article-title":"Preoperative thrombocytosis and poor prognostic factors in endometrial cancer","volume":"15","author":"Heng","year":"2014","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"key":"10.3233\/CBM-210215_ref34","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.ygyno.2013.08.032","article-title":"Preoperative anemia, leukocytosis and thrombocytosis identify aggressive endometrial carcinomas","volume":"131","author":"Nj\u00f8 lstad","year":"2013","journal-title":"Gynecologic Oncology"},{"key":"10.3233\/CBM-210215_ref35","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1111\/IGC.0b013e3181a47d47","article-title":"Prognostic significance of preoperative thrombocytosis in patients with endometrial carcinoma in an inner-city population","volume":"19","author":"Gorelick","year":"2009","journal-title":"International Journal of Gynecologic Cancer"},{"key":"10.3233\/CBM-210215_ref36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/9213074","article-title":"Mean Platelet Volume (MPV): New perspectives for an old marker in the course and prognosis of inflammatory conditions","volume":"9213074","author":"Korniluk","year":"2019","journal-title":"Mediators of Inflammation"},{"key":"10.3233\/CBM-210215_ref37","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1080\/09537104.2016.1224828","article-title":"New roles for mean platelet volume measurement in the clinical practice","volume":"27","author":"Noris","year":"2016","journal-title":"Platelets"},{"key":"10.3233\/CBM-210215_ref38","doi-asserted-by":"crossref","first-page":"e22438","DOI":"10.1002\/jcla.22438","article-title":"Evaluation of complete blood count parameters to predict endometrial cancer","volume":"32","author":"Yayla Abide","year":"2018","journal-title":"Journal of Clinical Laboratory Analysis"},{"key":"10.3233\/CBM-210215_ref39","doi-asserted-by":"crossref","first-page":"5397","DOI":"10.7314\/APJCP.2015.16.13.5397","article-title":"Platelet indices may be useful in discrimination of benign and malign endometrial lesions, and early and advanced stage endometrial cancer","volume":"13","author":"Kurtoglu","year":"2015","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"key":"10.3233\/CBM-210215_ref40","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3109\/01443615.2012.758089","article-title":"Platelet volume as a parameter for platelet activation in patients with endometrial cancer","volume":"3","author":"Oge","year":"2013","journal-title":"J Obstetrics and Gynaecology"},{"key":"10.3233\/CBM-210215_ref41","doi-asserted-by":"crossref","first-page":"e17818","DOI":"10.1097\/MD.0000000000017818","article-title":"Preoperative platelet morphology parameters as prognostic predictors for endometrial malignant carcinoma stage and progesterone receptor","volume":"98","author":"Song","year":"2019","journal-title":"Medicine (Baltimore)"}],"container-title":["Cancer Biomarkers"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/CBM-210215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:08:42Z","timestamp":1777385322000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/CBM-210215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,18]]},"references-count":41,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3233\/cbm-210215","relation":{},"ISSN":["1875-8592","1574-0153"],"issn-type":[{"value":"1875-8592","type":"electronic"},{"value":"1574-0153","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7,18]]}}}