{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:36:37Z","timestamp":1777480597412,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CBM"],"published-print":{"date-parts":[[2022,5,13]]},"abstract":"<jats:p>OBJECTIVES &amp; METHODS: CINtec PLUS and cobas HPV tests were compared for triaging patients referred to colposcopy with a history of LSIL cytology in a 2-year prospective study. Cervical specimens were tested once at enrollment, and test positivity rates determined. Test performance was ascertained with cervical intraepithelial neoplasia grade 2 or worse (CIN2+) and CIN3 or worse (CIN3+) serving as clinical endpoints. RESULTS: In all ages, (19\u201376 years, n= 598), 44.3% tested CINtec PLUS positive vs. 55.4% HPV positive (p&lt; 0.001). To detect CIN2+ (n= 99), CINtec PLUS was 81.8% sensitive vs. 93.9% for HPV testing (p= 0.009); genotype 16\/18-specific sensitivity was 46.5%. Specificity was 52.9% vs. 36.6%, respectively (p&lt; 0.001). In all ages, to detect CIN3+ (n= 44), sensitivity was 93.2% for both tests; genotype 16\/18-specific sensitivity was 52.3%. Specificity was 48.4% for CINtec PLUS vs. 31.1% for HPV testing (p&lt; 0.001). In patients &lt; 30 years, CINtec was 91.7% sensitive vs 95.8% for HPV testing (p= 0.549). CONCLUSIONS: CINtec PLUS or cobas HPV test could serve as a predictor of CIN3+ with high sensitivity in patients referred to colposcopy with a history of LSIL regardless of age while significantly reducing the number of LSIL referral patients requiring further investigations and follow-up in colposcopy clinics.<\/jats:p>","DOI":"10.3233\/cbm-210366","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T11:25:30Z","timestamp":1641295530000},"page":"347-358","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of CINtec PLUS cytology and cobas HPV test for triaging Canadian patients with LSIL cytology referred to colposcopy: A two-year prospective study"],"prefix":"10.1177","volume":"34","author":[{"given":"Laura","family":"Gilbert","sequence":"first","affiliation":[{"name":"Memorial University, Faculty of Medicine, St. John\u2019s, Canada"},{"name":"Eastern Health, Public Health Microbiology Laboratory, St. John\u2019s, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Ratnam","sequence":"additional","affiliation":[{"name":"Memorial University, Faculty of Medicine, St. John\u2019s, Canada"},{"name":"McMaster University, St. Joseph\u2019s Healthcare, Hamilton, Canada"},{"name":"McGill University, Faculty of Medicine, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Jang","sequence":"additional","affiliation":[{"name":"McMaster University, St. Joseph\u2019s Healthcare, Hamilton, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Alaghehbandan","sequence":"additional","affiliation":[{"name":"University of British Columbia, Faculty of Medicine, Vancouver, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miranda","family":"Schell","sequence":"additional","affiliation":[{"name":"McMaster University, Hamilton Health Sciences, Hamilton, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob","family":"Needle","sequence":"additional","affiliation":[{"name":"Memorial University, Faculty of Medicine, St. John\u2019s, Canada"},{"name":"Eastern Health, Public Health Microbiology Laboratory, St. John\u2019s, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Ecobichon-Morris","sequence":"additional","affiliation":[{"name":"McMaster University, St. Joseph\u2019s Healthcare, Hamilton, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnav","family":"Wadhawan","sequence":"additional","affiliation":[{"name":"McMaster University, St. Joseph\u2019s Healthcare, Hamilton, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dustin","family":"Costescu","sequence":"additional","affiliation":[{"name":"McMaster University, Hamilton Health Sciences, Hamilton, 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