{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:55:41Z","timestamp":1790819741889,"version":"4.1.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CBM"],"published-print":{"date-parts":[[2022,5,19]]},"abstract":"<jats:p>BACKGROUND: The relationship of the ABO blood group system with the immune response is known, but its relationship with immune checkpoint inhibitors (ICIs) has not been clearly investigated until now. OBJECTIVE: In this study, the relationship between different blood groups and nivolumab treatment response in patients with advanced malignant melanoma was investigated. METHODS: The data of patients who used nivolumab for advanced malignant melanoma between April 2018 and April 2021 were retrospectively reviewed. RESULTS: A total of 73 patients were included in the study. In the progression-free survival (PFS) analysis according to blood groups, it was 3.9\u00a0months, 16.1\u00a0months, 20.0\u00a0months and 3.0\u00a0months for A, B, AB and O, respectively (p= 0.1). Overall survival (OS) analysis according to blood groups was 5.1\u00a0months, 25.0\u00a0months, 20.0\u00a0months and 9.3\u00a0months for A, B, AB and O, respectively (p= 0.1). The B antigen group (B or AB) had significantly longer PFS and OS than the non-B antigen group (A or O) (16.1 vs. 3.5\u00a0months for PFS, respectively, p= 0.03; 20.0 vs. 7.4\u00a0months for OS, respectively, p= 0.02). CONCLUSIONS: The presence of B antigen provides a significant advantage in terms of survival in patients using ICIs for advanced melanoma.<\/jats:p>","DOI":"10.3233\/cbm-210455","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T11:26:16Z","timestamp":1641295576000},"page":"329-336","source":"Crossref","is-referenced-by-count":4,"title":["Predictive and prognostic effect of ABO blood group on immune checkpoint inhibitors"],"prefix":"10.1177","volume":"34","author":[{"given":"Yakup","family":"Ergun","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Batman Training and Research Hospital, Batman, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selin Akturk","family":"Esen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, University of Health Sciences Ankara City Hospital, Ankara, 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