{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:38:00Z","timestamp":1777480680325,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CBM"],"published-print":{"date-parts":[[2022,12,19]]},"abstract":"<jats:p>BACKGROUND: Post-hepatectomy liver failure (PHLF) is a severe complication of liver surgery in hepatocellular carcinoma (HCC) patients. Reduced lean body mass (LBM) decreases the immune activity and increases adverse clinical outcomes among cancer patients. OBJECTIVE: We aimed to assess the association between LBM and PHLF in HCC patients. METHODS: PHLF was defined and graded based on the International Study Group of Liver Surgery (ISGLS) criteria. Patients with Grade B or Grade C were included in PHLF \u2a7e Grade B group, while others in PHLF &lt; Grade B group. LBM was measured via preoperative computed tomography images. Binary logistic regression was applied for investigating the association between LBM and PHLF. The receiver operating characteristic curve was used to identify potential cut-off values and assess the predictive ability of the measured variables. RESULTS: The PHLF \u2a7e Grade B group had significantly lower LBM levels (means \u00b1 standard deviation: 57.0 \u00b1 14.1) than PHLF &lt; Grade B group (67.2 \u00b1 15.7) (p&lt; 0.001). After controlling other variables, LBM was an independent protective factor for PHLF \u2a7e Grade B (Odds Ratio: 0.406, 95% confidence interval: 0.172\u20130.957, p= 0.039). The prevalence of PHLF \u2a7e Grade B in each quartile of LBM was 29.4% (15\/51), 25.5% (13\/51), 19.2% (10\/52) and 4.0% (2\/50), respectively (ptrend&lt; 0.001). CONCLUSIONS: LBM might be a protective factor for PHLF in HCC patients. Our findings might help to develop a novel strategy to reduce the occurrence of hepatic dysfunction following major liver resection. Multicentric prospective studies and further molecular biologic investigation are needed.<\/jats:p>","DOI":"10.3233\/cbm-220172","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T11:38:40Z","timestamp":1668512320000},"page":"419-427","source":"Crossref","is-referenced-by-count":0,"title":["Lean body mass predicts postoperative liver failure in patients with hepatocellular carcinoma"],"prefix":"10.1177","volume":"35","author":[{"given":"Zeng-Yao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, China"},{"name":"Department of Interventional Medicine, The First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China"},{"name":"Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao-Hui","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Urology Surgery, Heilongjiang Provincial Hospital, Harbin, Heilongjiang, China"},{"name":"Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, China"},{"name":"Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Xi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui-Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Intensive Care Unit, Heilongjiang Academy of Medical Science, Harbin, Heilongjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/CBM-220172_ref1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.surg.2010.10.001","article-title":"Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery 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database","volume":"240","author":"Poon","year":"2004","journal-title":"Ann Surg"},{"key":"10.3233\/CBM-220172_ref8","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S1470-2045(09)70064-6","article-title":"Management of chemotherapy-associated hepatotoxicity in colorectal liver metastases","volume":"10","author":"Chun","year":"2009","journal-title":"Lancet Oncol"},{"key":"10.3233\/CBM-220172_ref9","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0092-8674(03)00318-0","article-title":"Aging reduces proliferative capacities of liver by switching pathways of C\/EBPalpha growth arrest","volume":"113","author":"Iakova","year":"2003","journal-title":"Cell"},{"key":"10.3233\/CBM-220172_ref10","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1056\/NEJM199412083312303","article-title":"Perioperative nutritional support in patients undergoing hepatectomy for hepatocellular carcinoma","volume":"331","author":"Fan","year":"1994","journal-title":"N Engl J 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Muscle"},{"key":"10.3233\/CBM-220172_ref31","doi-asserted-by":"crossref","first-page":"e13516","DOI":"10.1111\/apha.13516","article-title":"Pathophysiological mechanisms explaining poor clinical outcome of older cancer patients with low skeletal muscle mass","volume":"231","author":"Looijaard","year":"2021","journal-title":"Acta Physiol (Oxf)"},{"key":"10.3233\/CBM-220172_ref32","doi-asserted-by":"crossref","first-page":"e13370","DOI":"10.1111\/obr.13370","article-title":"The magnitude and progress of lean body mass, fat-free mass, and skeletal muscle mass loss following bariatric surgery: A systematic review and meta-analysis","volume":"23","author":"Nuijten","year":"2022","journal-title":"Obes Rev"},{"key":"10.3233\/CBM-220172_ref33","doi-asserted-by":"crossref","unstructured":"H. Ungefroren, D. Witte, C. Fiedler, T. Gadeken, R. Kaufmann, H. Lehnert, F. Gieseler and B.H. Rauch, The Role of PAR2 in TGF-beta1-Induced ERK Activation and Cell Motility, Int J Mol Sci 18 (2017).","DOI":"10.3390\/ijms18122776"},{"key":"10.3233\/CBM-220172_ref34","doi-asserted-by":"crossref","unstructured":"G. Fonseca, J. Farkas, E. Dora, S. von Haehling and M. 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