{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:56:51Z","timestamp":1778936211622,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Biomarkers"],"published-print":{"date-parts":[[2025,1]]},"abstract":"\n BACKGROUND<\/jats:title>\n Liquid biopsy (LB) is used to detect epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) and has been demonstrated to have prognostic and predictive value.<\/jats:p>\n <\/jats:sec>\n \n OBJECTIVE<\/jats:title>\n \n To associate the rates of\n EGFR<\/jats:italic>\n and T790M mutations detected by LB during disease progression after first- or second-generation EGFR-TKIs with clinical characteristics and survival outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n \n From January 2018 to December 2021, 295 patients with advanced EGFR mutant (EGFRm) NSCLC treated with first- or second-generation EGFR-TKIs were retrospectively analyzed. LB was collected at the time of progression. The frequency of EGFR\n \n \n \n \n \n \n T<\/mml:mi>\n <\/mml:mrow>\n 790<\/mml:mn>\n \n M<\/mml:mi>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:msup>\n <\/mml:math>\n <\/jats:inline-formula>\n mutations, overall survival (OS), and the clinical characteristics associated with LB positivity were determined.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n The prevalence of EGFR\n \n \n \n \n \n \n T<\/mml:mi>\n <\/mml:mrow>\n 790<\/mml:mn>\n \n M<\/mml:mi>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:msup>\n <\/mml:math>\n <\/jats:inline-formula>\n mutation detected using LB was 44%. In patients with negative vs. positive LB, the median OS was 45.0 months vs. 25.0 months (\n \n \n p<\/mml:mi>\n =<\/mml:mo>\n <\/mml:math>\n <\/jats:inline-formula>\n 0.0001), respectively. Patients with a T790M mutation receiving osimertinib had a median OS of 44 months (95% CI [33.05\u201354.99]). Clinical characteristics associated with positive LB at progression extra-thoracic involvement,\n \n \n ><\/mml:mo>\n <\/mml:math>\n <\/jats:inline-formula>\n 3 metastatic sites, and bone metastases.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n Our findings showed that LB positivity was associated with worse survival outcomes and specific clinical characteristics. This study also confirmed the feasibility and detection rate of T790M mutation in a Latin American population.<\/jats:p>\n <\/jats:sec>","DOI":"10.3233\/cbm-230124","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T11:27:52Z","timestamp":1702380472000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Liquid biopsy in clinical outcomes and detection of T790M mutation in metastatic non-small cell lung cancer after progression to EGFR-TKI"],"prefix":"10.1177","volume":"42","author":[{"given":"David","family":"Heredia","sequence":"first","affiliation":[{"name":"Thoracic Oncology Unit, Thoracic Oncology Department, Instituto Nacional de Cancerolog\u00eda, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Bola\u00f1o-Guerra","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Central Militar, Mexico City, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Valencia-Velarde","sequence":"additional","affiliation":[{"name":"Thoracic Oncology Unit, Thoracic Oncology Department, Instituto Nacional de Cancerolog\u00eda, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar Varela","family":"Santoyo","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Centro Oncol\u00f3gico Estatal, ISSSEMyN, Toluca, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Lara-Mej\u00eda","sequence":"additional","affiliation":[{"name":"Thoracic Oncology Unit, Thoracic Oncology Department, Instituto Nacional de Cancerolog\u00eda, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"C\u00e1rdenas-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Thoracic Oncology Unit, Thoracic Oncology Department, Instituto Nacional de Cancerolog\u00eda, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Orozco","sequence":"additional","affiliation":[{"name":"Neuroimmunology Laboratory, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graciela","family":"Cruz-Rico","sequence":"additional","affiliation":[{"name":"Thoracic Oncology Unit, Thoracic Oncology Department, Instituto Nacional de Cancerolog\u00eda, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1164-3779","authenticated-orcid":false,"given":"Oscar","family":"Arrieta","sequence":"additional","affiliation":[{"name":"Thoracic Oncology Unit, Thoracic Oncology Department, Instituto Nacional de Cancerolog\u00eda, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,11,23]]},"reference":[{"key":"e_1_3_5_2_2","unstructured":"The Global Cancer Observatory Globocan 2020 International Agency for Research on Cancer 419 (2020) 1\u20132."},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.032698"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810699"},{"key":"e_1_3_5_6_2","first-page":"1","article-title":"The diagnostic accuracy of circulating tumor DNA for the detection of EGFR-T790M mutation in NSCLC: A systematic review and meta-analysis","volume":"8","author":"Passiglia F.","year":"2018","unstructured":"Passiglia F., Rizzo S., Di Maio M., Galvano A., Badalamenti G., List\u00ec A., Gulotta L., Castiglia M., Bazan V., Russo A., Fulfaro F., The diagnostic accuracy of circulating tumor DNA for the detection of EGFR-T790M mutation in NSCLC: A systematic review and meta-analysis, Sci Rep 8 (2018), 1\u201310.","journal-title":"Sci Rep"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2015.08.010"},{"key":"e_1_3_5_8_2","first-page":"1","article-title":"Updated Frequency of EGFR and KRAS mutations in NonSmall-Cell Lung Cancer in Latin America The Latin-American Consortium for the Investigation of Lung Cancer","volume":"90","author":"Arrieta O.","year":"2015","unstructured":"Arrieta O., Andr\u00e9s F., Mart\u00edn C., M\u00e1s-l\u00f3pez L., Corrales-rodr\u00edguez L., Bramuglia G., Castillo-fernandez O., Meyerson M., Amieva-rivera E., Campos-parra A.D., Carranza H., Carlos J., De G., Powazniak Y., Aldaco-sarvide F., Vargas C., Trigo M., Magallanes-maciel M., Otero J., S\u00e1nchez-reyes R., Cuello M., Updated Frequency of EGFR and KRAS mutations in NonSmall-Cell Lung Cancer in Latin America The Latin-American Consortium for the Investigation of Lung Cancer, J Thorac Oncol 90 (2015), 1\u20137.","journal-title":"J Thorac Oncol"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713137"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz437.001"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.78.7994"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz399"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044238"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-2246"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-017-0497-2"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2020-206668"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-10288-8"},{"key":"e_1_3_5_18_2","unstructured":"Takahisa Kawamura S.O. Hirotsugu Kenmotsu* Clinical Factors Predicting Detection of T790MRe-biopsyn in Re-biopsy for EGFR-Mutant Non-Small Cell Lung Cancer Clin Lung Cancer 11 (2010) 211\u2013215."},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.3747\/co.27.5347"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx706"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep06269"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S161382"},{"key":"e_1_3_5_23_2","first-page":"9018","article-title":"Complete clearance of plasma EGFR mutations as a predictor of outcome on osimertinib in the AURA trial","volume":"35","author":"Thress K.S.","year":"2017","unstructured":"Thress K.S., Markovets A., Barrett J.C., Chmielecki J., Goldberg S.B., Shepherd F.A., Vowler S., Oxnard G.R., Complete clearance of plasma EGFR mutations as a predictor of outcome on osimertinib in the AURA trial, Https:\/\/DoiOrg\/ 101200\/JCO20173515_suppl9018 35 (2017), 9018\u20139018.","journal-title":"Https:\/\/DoiOrg\/ 101200\/JCO20173515_suppl9018"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.0173"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2019-206381"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2016.01.019"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.03.150"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx017"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2019.1645354"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2016.05.036"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.08.447"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.66.7162"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-0895"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.02.003"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2021.06.017"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2020.02.021"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-22-745"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568009618666180308125110"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000648"},{"key":"e_1_3_5_40_2","doi-asserted-by":"crossref","unstructured":"Patel S.H. Rimner A. Foster A. Zhang Z. Woo K.M. Yu H.A. Riely G.J. Wu A.J. Lung cancer 108 (2017) 109\u2013114.","DOI":"10.1016\/j.lungcan.2017.03.010"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2019.03.017"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3519"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2692"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.02.012"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32503"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1612674"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy474"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0267846"}],"container-title":["Cancer Biomarkers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/CBM-230124","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/CBM-230124","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/CBM-230124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:11:14Z","timestamp":1777385474000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/CBM-230124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,23]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.3233\/CBM-230124"],"URL":"https:\/\/doi.org\/10.3233\/cbm-230124","relation":{},"ISSN":["1574-0153","1875-8592"],"issn-type":[{"value":"1574-0153","type":"print"},{"value":"1875-8592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,23]]},"article-number":"CBM-230124"}}