{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:15:44Z","timestamp":1788369344988,"version":"build-2803163510"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Biomarkers"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The national lung screening trial (NLST) demonstrated a reduction in lung cancer mortality with lowdose CT (LDCT) compared to chest x-ray (CXR) screening. Overdiagnosis was high (79%) among bronchoalveolar carcinoma (BAC) currently replaced by adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA) and adenocarcinoma of low malignant potential (LMP) exhibiting 100% disease specific survival (DSS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Compare the outcomes and proportions of BAC, AIS, MIA, and LMP among NLST screendetected stage IA NSCLC with overdiagnosis rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Whole slide images were reviewed by a thoracic pathologist from 174 of 409 NLST screen-detected stage IA LUAD. Overdiagnosis rates were calculated from follow-up cancer incidence rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Most BAC were reclassified as AIS\/MIA\/LMP (20\/35 = 57%). The 7-year DSS was 100% for AIS\/MIA\/LMP and 94% for BAC. Excluding AIS\/MIA\/LMP, BAC behaved similarly to NSCLC (7-year DSS: 86% vs. 83%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009 0.85) The overdiagnosis rate of LDCT stage IA NSCLC was 16.6% at 11.3-years, matching the proportion of AIS\/MIA\/LMP (16.2%) but not AIS\/MIA (3.5%) or BAC (22.8%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AIS\/MIA\/LMP proportionally matches the overdiagnosis rate among stage IA NSCLC in the NLST, exhibiting 100% 7-year DSS. Biomarkers designed to recognize AIS\/MIA\/LMP preoperatively, would be useful to prevent overtreatment of indolent screen-detected cancers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/cbm-230452","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T10:50:23Z","timestamp":1721991023000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Pulmonary adenocarcinoma of low malignant potential defines indolent NSCLC associated with overdiagnosis in the national lung screening trial"],"prefix":"10.1177","volume":"42","author":[{"given":"Eric J.","family":"Burks","sequence":"first","affiliation":[{"name":"Boston University Chobanian and Avedisian School of Medicine","place":["USA"]},{"name":"Lahey Hospital and Medical Center","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis B.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Lahey Hospital and Medical Center","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly M.","family":"Rieger-Christ","sequence":"additional","affiliation":[{"name":"Lahey Hospital and Medical Center","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1102873"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.12738"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2019.05.044"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000630"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2016.03.011"},{"key":"e_1_3_3_7_2","unstructured":"WHO Classification of Tumours Editorial Board Thoracic tumours 5th ed. 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