{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:28:16Z","timestamp":1791250096928,"version":"4.1.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>BACKGROUND: The purpose of this study was to determine the predictive value of a single measurement of reactive hyperemia (RH) and brachial flow-mediated dilation (FMD) in patients with established stable coronary artery disease (CAD). METHODS: RH and brachial artery FMD were ultrasonographically measured in 325 patients with stable CAD. Patients were followed for cerebro-cardiovascular events. The median follow-up was 3.7 years (range 0.01\u20135.7 years). RESULTS: Sixty-seven patients (20.6%) had an cerebro-cardiovascular event. Patients with subsequent events had lower FMD (4.9 \u00b1 3.3% versus 6.3 \u00b1 3.5%, p = 0.003), higher brachial artery resting diameter (5.1 \u00b1 0.7 mm versus 4.8 \u00b1 0.7 mm, p = 0.002) and lower NMD (11.2 \u00b1 5.1% versus 12.8 \u00b1 5.4%, p = 0.02), while the mean hyperemic flow velocity and shear stress did not differ from patients without cerebro-cardiovascular events. Cox proportional hazard model adjusted for sex, age, BMI, and traditional cardiovascular risk factors revealed a hazard ratio of 0.84 for lower FMD (p = 0.01). CONCLUSIONS: We conclude that single spot measurements of peak RH do not provide long-term prognostic information, but evaluation of conduit artery FMD predicts long-term cerebro-cardiovascular events in patients with stable CAD. The prognostic value of FMD is incremental to traditional cardiovascular risk factors and may therefore be of clinical importance.<\/jats:p>","DOI":"10.3233\/ch-131720","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T13:40:42Z","timestamp":1575294042000},"page":"247-257","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Predictive value of brachial reactive hyperemia and flow-mediated dilation in stable coronary artery disease"],"prefix":"10.1177","volume":"56","author":[{"given":"Mir Abolfazl","family":"Ostad","sequence":"first","affiliation":[{"name":"Department of Medicine II, University Medical Center Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp S.","family":"Wild","sequence":"additional","affiliation":[{"name":"Department of Medicine II, University Medical Center Mainz, Germany"},{"name":"Center for Thrombosis and Hemostasis, University Medical Center Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Schnorbus","sequence":"additional","affiliation":[{"name":"Department of Medicine II, University Medical Center Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Medicine II, University Medical Center Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Munzel","sequence":"additional","affiliation":[{"name":"Department of Medicine II, University Medical Center Mainz, Germany"},{"name":"Center for Thrombosis and Hemostasis, University Medical Center Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ascan","family":"Warnholtz","sequence":"additional","affiliation":[{"name":"Kardiologische Praxis Dr. Tauchert, PD Dr. Warnholtz, Griesheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,1,1]]},"container-title":["Clinical Hemorheology and Microcirculation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/CH-131720","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/CH-131720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:11:12Z","timestamp":1777389072000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/CH-131720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.3233\/CH-131720"],"URL":"https:\/\/doi.org\/10.3233\/ch-131720","relation":{},"ISSN":["1386-0291","1875-8622"],"issn-type":[{"value":"1386-0291","type":"print"},{"value":"1875-8622","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,1]]}}}