{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:17:51Z","timestamp":1791346671967,"version":"4.3.1"},"reference-count":0,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>\n                    The hematocrit-to-viscosity ratio (HVR) has been widely used has an estimate of red blood cell (RBC) oxygen transport effectiveness into the microvasculature or as an oxygen delivery index. However, no study investigated the possibility of HVR to truly reflect RBC oxygen transport effectiveness or to be an oxygen delivery index. We measured blood viscosity at high shear rate (225 s\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), hematocrit, HVR, as well as the microvascular oxyhemoglobin saturation (TOI; tissue oxygen index) by spatial resolved near-infrared spectroscopy (NIRS) at cerebral and muscle levels in three population known to have various degrees of hemorheological abnormalities: healthy subjects (AA), patients with sickle cell SC disease (SC) characterized by moderate anemia and patients with sickle cell anemia (SS) marked by severe anemia. At both the cerebral and muscle level, HVR was positively correlated with TOI (r = 0.28; p = 0.03 and r = 0.38; p = 0.003, at the cerebral and muscle level, respectively). These findings suggest that HVR probably play a key role in blood flow and hemodynamic regulation in the microvasculature, hence modulating the amount of oxygen available for tissues. Nevertheless, the strengths of the associations are weak (R\n                    <jats:sup>2<\/jats:sup>\n                    &lt; 0.50), suggesting that other determinants modulate microvascular blood flow and oxygenation, such as vascular geometry and vasomotor reserve.\n                  <\/jats:p>","DOI":"10.3233\/ch-131742","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T13:50:17Z","timestamp":1575294617000},"page":"37-43","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":44,"title":["Is there a relationship between the hematocrit-to-viscosity ratio and microvascular oxygenation in brain and muscle?"],"prefix":"10.1177","volume":"59","author":[{"given":"Xavier","family":"Waltz","sequence":"first","affiliation":[{"name":"Inserm 665, Pointe-\u00e0-Pitre, F-97159 Guadeloupe, Universit\u00e9 des Antilles et de la Guyane, Pointe-\u00e0-Pitre, F-97157, France"},{"name":"Laboratory of Excellence GR-Ex \u00ab The red cell : from genesis to death \u00bb, PRES Sorbonne Paris Cit\u00e9, 75015, Paris, France"},{"name":"Universit\u00e9 des Antilles et de la Guyane, Laboratoire ACTES (EA 3596), D\u00e9partement de Physiologie, Pointe-\u00e0-Pitre, Guadeloupe, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Dominique","family":"Hardy-Dessources","sequence":"additional","affiliation":[{"name":"Inserm 665, Pointe-\u00e0-Pitre, F-97159 Guadeloupe, Universit\u00e9 des Antilles et de la Guyane, Pointe-\u00e0-Pitre, F-97157, France"},{"name":"Laboratory of Excellence GR-Ex \u00ab The red cell : from genesis to death \u00bb, PRES Sorbonne Paris Cit\u00e9, 75015, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Lemonne","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Transversale de la Dr\u00e9panocytose, Centre Hospitalier et Universitaire de Pointe-\u00e0-Pitre, Pointe-\u00e0-Pitre, Guadeloupe, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani\u00e8le","family":"Mougenel","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Transversale de la Dr\u00e9panocytose, Centre Hospitalier et Universitaire de Pointe-\u00e0-Pitre, Pointe-\u00e0-Pitre, Guadeloupe, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Laure","family":"Lalanne-Mistrih","sequence":"additional","affiliation":[{"name":"Inserm 665, Pointe-\u00e0-Pitre, F-97159 Guadeloupe, Universit\u00e9 des Antilles et de la Guyane, Pointe-\u00e0-Pitre, F-97157, France"},{"name":"CIC-EC 802 Inserm, Centre Hospitalier Universitaire de Pointe-\u00e0-Pitre, Pointe-\u00e0-Pitre, Guadeloupe, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Lamarre","sequence":"additional","affiliation":[{"name":"Inserm 665, Pointe-\u00e0-Pitre, F-97159 Guadeloupe, Universit\u00e9 des Antilles et de la Guyane, Pointe-\u00e0-Pitre, F-97157, France"},{"name":"Laboratory of Excellence GR-Ex \u00ab The red cell : from genesis to death \u00bb, PRES Sorbonne Paris Cit\u00e9, 75015, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Tarer","sequence":"additional","affiliation":[{"name":"Centre de r\u00e9f\u00e9rence maladies rares pour la dr\u00e9panocytose aux Antilles-Guyane, Centre Hospitalier et Universitaire de Pointe-\u00e0-Pitre, Pointe-\u00e0-Pitre, Guadeloupe, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Tressi\u00e8res","sequence":"additional","affiliation":[{"name":"CIC-EC 802 Inserm, Centre Hospitalier Universitaire de Pointe-\u00e0-Pitre, Pointe-\u00e0-Pitre, Guadeloupe, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryse","family":"Etienne-Julan","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Transversale de la Dr\u00e9panocytose, Centre Hospitalier et Universitaire de Pointe-\u00e0-Pitre, Pointe-\u00e0-Pitre, Guadeloupe, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Hue","sequence":"additional","affiliation":[{"name":"Universit\u00e9 des Antilles et de la Guyane, Laboratoire ACTES (EA 3596), D\u00e9partement de Physiologie, Pointe-\u00e0-Pitre, Guadeloupe, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Connes","sequence":"additional","affiliation":[{"name":"Inserm 665, Pointe-\u00e0-Pitre, F-97159 Guadeloupe, Universit\u00e9 des Antilles et de la Guyane, Pointe-\u00e0-Pitre, F-97157, France"},{"name":"Laboratory of Excellence GR-Ex \u00ab The red cell : from genesis to death \u00bb, PRES Sorbonne Paris Cit\u00e9, 75015, Paris, France"},{"name":"Universit\u00e9 des Antilles et de la Guyane, Laboratoire ACTES (EA 3596), D\u00e9partement de Physiologie, Pointe-\u00e0-Pitre, Guadeloupe, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,1,1]]},"container-title":["Clinical Hemorheology and Microcirculation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/CH-131742","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/CH-131742","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:05:07Z","timestamp":1777388707000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/CH-131742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.3233\/CH-131742"],"URL":"https:\/\/doi.org\/10.3233\/ch-131742","relation":{"is-cited-by":[{"id-type":"doi","id":"10.3389\/fnins.2019.00644","asserted-by":"object"},{"id-type":"doi","id":"10.3389\/fcvm.2018.00138","asserted-by":"object"},{"id-type":"doi","id":"10.3389\/fneur.2019.00871","asserted-by":"object"}]},"ISSN":["1386-0291","1875-8622"],"issn-type":[{"value":"1386-0291","type":"print"},{"value":"1875-8622","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1]]}}}