{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T06:32:49Z","timestamp":1781332369580,"version":"3.54.1"},"reference-count":53,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T00:00:00Z","timestamp":1431302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2015,5,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>INTRODUCTION:<\/jats:bold>\n                    Obesity is associated with impaired microvascular endothelial\n          function. We aimed to determine the effects of orlistat and sibutramine treatment on\n          microvascular endothelial function, anthropometric and lipid profile, blood pressure (BP),\n          and heart rate (HR).\n                    <jats:bold>METHODS:<\/jats:bold>\n                    76 subjects were recruited and randomized to\n          receive orlistat 120\u200amg three times daily or sibutramine 10\u200amg daily for 9 months.\n          Baseline weight, BMI, BP, HR and lipid profile were taken. Microvascular endothelial\n          function was assessed using laser Doppler fluximetry and iontophoresis process. Maximum\n          change (max), percent change (% change) and peak flux (peak) in perfusion to acetylcholine\n          (ACh) and sodium nitroprusside (SNP) iontophoresis were used to quantify endothelium\n          dependent and independent vasodilatations.\n                    <jats:bold>RESULTS:<\/jats:bold>\n                    24 subjects in both\n          groups completed the trial. After treatment, weight and BMI were decreased for both\n          groups. ACh\n                    <jats:sub>max<\/jats:sub>\n                    , ACh % change and ACh peak were increased in orlistat-treated\n          group but no difference was observed for sibutramine-treated group. BP and total\n          cholesterol (TC) were reduced for orlistat-treated group. HR was reduced for\n          orlistat-treated group but was increased in sibutramine-treated group.\n                    <jats:bold>CONCLUSION:<\/jats:bold>\n                    9 months treatment with orlistat significantly improved\n          microvascular endothelial function. This was associated with reductions in weight, BMI,\n          BP, HR, TC and low density lipoprotein cholesterol. No effect was seen in microvascular\n          endothelial function with sibutramine.\n                  <\/jats:p>","DOI":"10.3233\/ch-131765","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T05:24:23Z","timestamp":1432877063000},"page":"323-334","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["The effects of anti-obesity intervention with orlistat and sibutramine on          microvascular endothelial function"],"prefix":"10.1177","volume":"59","author":[{"given":"Belqes Abdullah Mohammad","family":"Al-Tahami","sequence":"first","affiliation":[{"name":"Pharmacology Vascular Laboratory, School of Medical Sciences,\r          Universiti Sains Malaysia, Kota Bharu, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ab Aziz Al-Safi","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, School of 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