{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:44:22Z","timestamp":1777499062861,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>\n                    Implantable long-term central venous port systems (CVPS) are widely used as a permanent means of accessing the vascular system for intravenous delivery of drugs, parenteral nutrition, blood transfusion, and blood sampling. These systems allow easy and repetitive puncture without causing much damage to the vessels. However, the body foreign surface of CVPS induces an inflammatory response with varying intensity (depending on the implant materials) that leads to formation of a fibrous tissue capsule around the implant. This study was designed to investigate the influence of bacterial infection on the tissue reaction induced by implanted CVPS in adult patients. 20 patients (9 women, 11 men, 58 \u00b1 14 yrs of age) were included in this study. These patients received explantation of a polysulfone based CVPS (ChemoSite\u2122, Covidien, Mansfield, USA) due to port related infections (patients with bacterial infections at the implantation site: group A, 5 men, 1 women) or to other reasons such as termination of treatment, thrombosis, or CVPS dysfunction (patients without bacterial infections, group B, 6 men, 8 women) 299.9 \u00b1 261.2 days after CVPS implantation. A sample of the encapsulating tissue covering the CVPS together with surrounding tissue (at least 1 \u00d7 1 cm\n                    <jats:sup>2<\/jats:sup>\n                    ) was placed in a small container with fixing agent, a buffered neutral 4% formalin solution (pH 7). Histological sections of the samples were prepared for light microscopic analysis after paraffin embedding. Sections of 3 \u03bcm were cut and stained with haematoxylin and eosin, Weigert's elastic stain, and Heidenhain's azan stain. There was no difference in thickness, collagen and elastin content, or cell and capillary density of the fibrous capsule between both groups. Due to the wound healing reaction involving angiogenesis and fibroblast activation cell density and number of capillaries in the capsule tissue of all patients showed a positive correlation (r = 0.45, p &lt; 0.05). However, the study demonstrated that at the end of the foreign body reaction the artificial tissue layer which covers the CVPS after implantation due to foreign body reaction shows only low reactivity towards infections.\n                  <\/jats:p>","DOI":"10.3233\/ch-141881","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T13:48:41Z","timestamp":1575294521000},"page":"107-113","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Tissue reaction induced by implanted venous access ports in adult patients after infection of the implantation site"],"prefix":"10.1177","volume":"58","author":[{"given":"B.","family":"Hiebl","sequence":"first","affiliation":[{"name":"Center for Medical Basic Research, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Hopperdietzel","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Institute of Veterinary Anatomy, Freie Universit\u00e4t Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"H\u00fcnigen","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Institute of Veterinary Anatomy, Freie Universit\u00e4t Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Dietze","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Institute of Veterinary Anatomy, Freie Universit\u00e4t Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Jung","sequence":"additional","affiliation":[{"name":"Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.M.","family":"Niehues","sequence":"additional","affiliation":[{"name":"Department of Radiology, Charit\u00e9-University Medicine Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,1]]},"container-title":["Clinical Hemorheology and Microcirculation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/CH-141881","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/CH-141881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:11:24Z","timestamp":1777389084000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/CH-141881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.3233\/CH-141881"],"URL":"https:\/\/doi.org\/10.3233\/ch-141881","relation":{},"ISSN":["1386-0291","1875-8622"],"issn-type":[{"value":"1386-0291","type":"print"},{"value":"1875-8622","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}