{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:08:37Z","timestamp":1785211717842,"version":"3.55.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CH"],"published-print":{"date-parts":[[2016,3,18]]},"DOI":"10.3233\/ch-151961","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T18:50:51Z","timestamp":1458327051000},"page":"151-163","source":"Crossref","is-referenced-by-count":4,"title":["Measurement of platelet aggregation functions using whole blood migration ratio in a microfluidic chip"],"prefix":"10.1177","volume":"62","author":[{"given":"Hong Seog","family":"Seo","sequence":"first","affiliation":[{"name":"KU-KIST Graduate School of Converging Science and Technology, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hyuk","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, College of Medicine, Korea University, Guro Gu, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miran","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, College of Medicine, Korea University, Guro Gu, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeong Ah","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, College of Medicine, Korea University, Guro Gu, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Hyun","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, College of Medicine, Korea University, Guro Gu, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Soo A.","family":"An","sequence":"additional","affiliation":[{"name":"College of Bionano Technology, Gachon Bionano Research Institute, Gachon University, Seongnam-si, Gyeonggi Do, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chae Seung","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, College of Medicine, Korea University, Guro Gu, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sehyun","family":"Shin","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, Korea University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/CH-151961_ref1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/cyto.990100413","article-title":"Correlated measurement of platelet release and aggregation in whole blood","volume":"10","author":"Ault","year":"1989","journal-title":"Cytometry"},{"key":"10.3233\/CH-151961_ref2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0014-2999(01)00733-6","article-title":"Inhibition of platelet function by administration of MRSa P2Y1 receptor antagonist","volume":"412","author":"Baurand","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"10.3233\/CH-151961_ref3","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/194927b0","article-title":"Aggregation of blood platelets by adenosine diphosphate and its reversal","volume":"194","author":"Born","year":"1962","journal-title":"Nature"},{"key":"10.3233\/CH-151961_ref4","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/205678a0","article-title":"Comparative effectiveness of adenosine analogues as inhibitors of blood-platelet aggregation and as vasodilators in man","volume":"205","author":"Born","year":"1965","journal-title":"Nature"},{"key":"10.3233\/CH-151961_ref5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/09537100400020161","article-title":"Can platelet aggregometry be standardized?","volume":"16","author":"Breddin","year":"2005","journal-title":"Platelets"},{"key":"10.3233\/CH-151961_ref6","first-page":"181","article-title":"Spontaneous platelet aggregation and coagulation parameters as risk factors for arterial occlusions in diabetics, Results of the PARD-Study","volume":"5","author":"Breddin","year":"1986","journal-title":"Int Angiol"},{"key":"10.3233\/CH-151961_ref7","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1055\/s-0038-1647966","article-title":"On the measurement of spontaneous platelet aggregation. The platelet aggregation test III. Methods and first clinical results","volume":"35","author":"Breddin","year":"1976","journal-title":"Thromb Haemost"},{"key":"10.3233\/CH-151961_ref8","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/j.1538-7836.2008.02896.x","article-title":"Fluoxetine (Prozac) augments platelet activation mediated through protease-activated receptors","volume":"6","author":"Dilks","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.3233\/CH-151961_ref9","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1182\/blood-2002-10-3027","article-title":"Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270","volume":"101","author":"Ding","year":"2003","journal-title":"Blood"},{"key":"10.3233\/CH-151961_ref10","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/BF02982079","article-title":"Identification, characterization, and inhibition of the platelet ADP receptors","volume":"74","author":"Gachet","year":"2001","journal-title":"Int J Hematol"},{"key":"10.3233\/CH-151961_ref11","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1182\/blood.V97.4.937","article-title":"Adenosine diphosphate strongly potentiates the ability of the chemokines MDC, TARC, and SDF-1 to stimulate platelet function","volume":"97","author":"Gear","year":"2001","journal-title":"Blood"},{"key":"10.3233\/CH-151961_ref12","doi-asserted-by":"crossref","first-page":"23352","DOI":"10.1074\/jbc.270.40.23352","article-title":"Characterization of the unique mechanism mediating the shear-dependent binding of soluble von Willebrand factor to platelets","volume":"270","author":"Goto","year":"1995","journal-title":"J Biol Chem"},{"key":"10.3233\/CH-151961_ref13","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1586\/erd.10.29","article-title":"Perioperative assessment of platelet function in patients under antiplatelet therapy","volume":"7","author":"Hofer","year":"2010","journal-title":"Expert Rev Med Devices"},{"key":"10.3233\/CH-151961_ref14","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1160\/TH07-09-0555","article-title":"A comparison of the antiplatelet effects of prasugrel and highdose clopidogrel as assessed by VASP-phosphorylation and light transmission aggregometry","volume":"99","author":"Jakubowski","year":"2008","journal-title":"Thromb Haemost"},{"key":"10.3233\/CH-151961_ref15","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1046\/j.1365-2796.2002.01027.x","article-title":"Individual variations of platelet inhibition after loading doses of clopidogrel","volume":"252","author":"Jaremo","year":"2002","journal-title":"J Intern Med"},{"key":"10.3233\/CH-151961_ref16","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3233\/CH-2012-1579","article-title":"Haemocompatibility testing of biomaterials using human platelets","volume":"53","author":"Jung","year":"2013","journal-title":"Clin Hemorheol Microcirc"},{"key":"10.3233\/CH-151961_ref17","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00277-009-0881-9","article-title":"Assessment of clopidogrel non-response by the PFA-100R system using the new test cartridge INNOVANCE R PFA P2Y","volume":"89","author":"Linnemann","year":"2010","journal-title":"Ann Hematol"},{"key":"10.3233\/CH-151961_ref18","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1111\/j.1538-7836.2004.00722.x","article-title":"The P2Y1 receptor plays an essential role in the platelet shape change induced by collagen when TxA2 formation is prevented","volume":"2","author":"Mangin","year":"2004","journal-title":"J Thromb Haemost"},{"key":"10.3233\/CH-151961_ref19","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1055\/s-0029-1220325","article-title":"Whole blood platelet aggregometry and platelet function testing","volume":"35","author":"McGlasson","year":"2009","journal-title":"Semin Thromb Hemost"},{"key":"10.3233\/CH-151961_ref20","first-page":"805","article-title":"Henry\u2019s clinical diagnosis and management by laboratory methods","volume":"22","author":"McPherson","year":"2011","journal-title":"Philadelphia: Saunders Elsevier"},{"key":"10.3233\/CH-151961_ref21","doi-asserted-by":"crossref","first-page":"4N","DOI":"10.1016\/j.amjcard.2006.09.008","article-title":"Current options in platelet function testing","volume":"98","author":"Michelson","year":"2006","journal-title":"Am J Cardiol"},{"key":"10.3233\/CH-151961_ref22","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1182\/blood-2002-12-3882","article-title":"Platelet-collagen interaction: Is GPVI the central receptor?","volume":"102","author":"Nieswandt","year":"2003","journal-title":"Blood"},{"key":"10.3233\/CH-151961_ref23","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1309\/AJCPTE3K1SGAPOIZ","article-title":"Assessment of platelet function on whole blood by multiple electrode aggregometry in high-risk patients with coronary artery disease receiving antiplatelet therapy","volume":"131","author":"Paniccia","year":"2009","journal-title":"Am J Clin Pathol"},{"key":"10.3233\/CH-151961_ref24","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00277-005-0029-5","article-title":"Agonists-induced platelet activation varies considerably in healthy male individuals: Studies by flow cytometry","volume":"85","author":"Panzer","year":"2006","journal-title":"Ann Hematol"},{"key":"10.3233\/CH-151961_ref25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3233\/CH-2012-1578","article-title":"Clinical importance of antiplatelet drugs in cardiovascular diseases","volume":"53","author":"Papp","year":"2013","journal-title":"Clin Hemorheol Microcirc"},{"key":"10.3233\/CH-151961_ref26","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1001\/archsurg.133.2.134","article-title":"The preoperative bleeding time test lacks clinical benefit: College of American Pathologists\u2019 and American Society of Clinical Pathologists\u2019 position article","volume":"133","author":"Peterson","year":"1998","journal-title":"Arch Surg"},{"key":"10.3233\/CH-151961_ref27","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3233\/CH-2012-1577","article-title":"Platelets in vascular disease, Platelets in vascular disease","volume":"53","author":"Reinhart","year":"2013","journal-title":"Clin Hemorheol Microcirc"},{"key":"10.3233\/CH-151961_ref28","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0049-3848(01)00344-9","article-title":"Methods and models to evaluate shear-dependent and surface reactivity-dependent antithrombotic efficacy","volume":"104","author":"Sakariassen","year":"2001","journal-title":"Thromb Res"},{"key":"10.3233\/CH-151961_ref29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1423-0410.2007.00912.x","article-title":"Storage of buffy-coat-derived platelets in additive solutions at 4 degrees C and 22 degrees C: Flow cytometry analysis of platelet glycoprotein expression","volume":"93","author":"Sandgren","year":"2007","journal-title":"Vox Sang"},{"key":"10.3233\/CH-151961_ref30","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3109\/09537104.2011.590255","article-title":"Succinate reverses in-vitro platelet inhibition by acetylsalicylic acid and P2Y receptor antagonists","volume":"23","author":"Spath","year":"2012","journal-title":"Platelets"},{"key":"10.3233\/CH-151961_ref31","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.thromres.2007.01.007","article-title":"Effect of physiologic shear stresses and calcium on agonist-induced platelet aggregation, secretion, and thromboxane A2 formation","volume":"120","author":"Viisoreanu","year":"2007","journal-title":"Thromb Res"},{"key":"10.3233\/CH-151961_ref32","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1160\/TH06-01-0046","article-title":"Correlation of a new point-of-care test with conventional optical aggregometry for the assessment of clopidogrel responsiveness","volume":"95","author":"von Beckerath","year":"2006","journal-title":"Thromb Haemost"},{"key":"10.3233\/CH-151961_ref33","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1093\/eurheartj\/ehp296","article-title":"inhibitors: Differences in properties and mechanisms of action and potential consequences for clinical use","volume":"30","author":"Wallentin","year":"2009","journal-title":"Eur Heart J"},{"key":"10.3233\/CH-151961_ref34","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1182\/blood.V30.5.625.625","article-title":"An ultra-structural basis for the shape changes induced in platelets by chilling","volume":"30","author":"White","year":"1967","journal-title":"Blood"},{"key":"10.3233\/CH-151961_ref35","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1002\/pmic.201100410","article-title":"Analysis of protein networks in resting and collagen receptor (GPVI)-stimulated platelet sub-proteomes","volume":"11","author":"Wright","year":"2011","journal-title":"Proteomics"}],"container-title":["Clinical Hemorheology and Microcirculation"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/CH-151961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:05:46Z","timestamp":1777388746000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/CH-151961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,18]]},"references-count":35,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/ch-151961","relation":{},"ISSN":["1386-0291","1875-8622"],"issn-type":[{"value":"1386-0291","type":"print"},{"value":"1875-8622","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,18]]}}}