{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:12:50Z","timestamp":1777497170435,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T00:00:00Z","timestamp":1443139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2016,5,13]]},"abstract":"<jats:p>\n                    Painful vaso-occlusive crisis (VOC) is the clinical hallmark of sickle cell disease (SCD). Microcirculatory hemodynamic changes following painful VOC may be indicative of future development of VOC events in subjects with SCD. The purpose of the present study was to determine alterations in conjunctival microvascular hemodynamics during non-crisis state in SCD subjects with a history of VOC. Conjunctival microcirculation imaging was performed to measure conjunctival diameter (D) and axial blood velocity (V) in 10 control and 30 SCD subjects. SCD subjects were categorized into two groups based on their history of VOC within a 2-year period before imaging (with or without VOC-H) and also based on whether there was progression in the rate of VOCs during a 2-year period following imaging as compared to before imaging (with or without VOC-P). Conjunctival V was significantly higher in SCD subjects with VOC-H than in both control subjects and SCD subjects without VOC-H (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u22640.03). Conjunctival V was also significantly higher in SCD subjects with VOC-P compared with control subjects and SCD subjects without VOC-P (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u22640.03). Assessment of the conjunctival microcirculation may be useful for understanding hemodynamic changes that lead to VOC events in SCD subjects.\n                  <\/jats:p>","DOI":"10.3233\/ch-151977","type":"journal-article","created":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T11:39:49Z","timestamp":1463139589000},"page":"359-367","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Conjunctival microvascular hemodynamics following vaso-occlusive crisis in sickle cell disease"],"prefix":"10.1177","volume":"62","author":[{"given":"Ali","family":"Kord Valeshabad","sequence":"first","affiliation":[{"name":"University of Illinois at Chicago","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Wanek","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Gaynes","sequence":"additional","affiliation":[{"name":"Loyola University Medical Center","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santosh L.","family":"Saraf","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Molokie","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago","place":["USA"]},{"name":"Jesse Brown VA Medical Center","place":["USA"]},{"name":"University of Illinois at Chicago","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahnaz","family":"Shahidi","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,9,25]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1992.tb02998.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3233\/CH-2009-1167"},{"key":"e_1_3_2_4_2","first-page":"127","article-title":"Microvascular determinants of blood flow behavior and HbSS erythrocyte plugging in microcirculation","volume":"8","author":"Baez S.","year":"1982","unstructured":"BaezS., KaulD.K. and NagelR.L., Microvascular determinants of blood flow behavior and HbSS erythrocyte plugging in microcirculation, Blood Cells 8 (1982), 127\u2013137.","journal-title":"Blood Cells"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830360211"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/03630269509005824"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2011.610478"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.4.1216.1216"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.8.2154.2154"},{"key":"e_1_3_2_10_2","first-page":"339","article-title":"Hemoglobin distribution width: A rapid assessment of dense red cells in the steady state and during painful crisis in sickle cell anemia","volume":"112","author":"Billett H.H.","year":"1988","unstructured":"BillettH.H., FabryM.E. and NagelR.L., Hemoglobin distribution width: A rapid assessment of dense red cells in the steady state and during painful crisis in sickle cell anemia, The Journal of Laboratory and Clinical Medicine 112 (1988), 339\u2013344.","journal-title":"The Journal of Laboratory and Clinical Medicine"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/108155890405200635"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.03.035"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.09.015"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2013.08.020"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2011.610914"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e328329e167"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1961.00960010826008"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V77.7.1405.1405"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1549-8719.2012.00182.x"},{"key":"e_1_3_2_20_2","first-page":"1","article-title":"Evidence-based management of sickle cell disease in the emergency department","volume":"13","author":"Glassberg J.","year":"2011","unstructured":"GlassbergJ., Evidence-based management of sickle cell disease in the emergency department, Emergency Medicine Practice 13 (2011), 1\u201320; 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