{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:11:10Z","timestamp":1777497070028,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,9,5]],"date-time":"2015-09-05T00:00:00Z","timestamp":1441411200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2015,9,5]]},"abstract":"\n PURPOSE:<\/jats:title>\n To evaluate the diagnostic benefits of multimodality imaging using image fusion with magnetic-resonance-imaging (MRI) and contrast-enhanced-ultrasound (CEUS) in an experimental small-animal-squamous-cell-carcinoma-model for the assessment of tissue hemodynamics and morphology.<\/jats:p>\n <\/jats:sec>\n \n MATERIAL AND METHODS:<\/jats:title>\n Human hypopharynx-carcinoma-cells were injected subcutaneously into the left flank of 15 female athymic nude rats. After 10 daysof subcutaneous tumor growth, CEUS and MRI measurements were performed using a high-end-ultrasound-system and 3-T-MRI. After successful point-to-point or plan registration, the registered MR-images were simultaneously shown with the respective ultrasound sectional plane. Data evaluation was performed using the digitally stored video sequence data sets by two experienced radiologists using a subjective 5-point scale.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n CEUS and MRI are well-known techniques for the assessment of tissue hemodynamics (score: mean 3.8 \u00b1 0.4 SD and score 3.8 \u00b1 0.4 SD). Real-time image fusion of MRI and CEUS yielded a significant ( p\u200a< \u200a0.001) improvement in score (score 4.8 \u00b1 0.4 SD). Reliable detection of small necrotic areas was possible in all animals with necrotic tumors. No significant intraobserver and interobserver variability was detected (kappa coefficient\u200a=\u200a+1).<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n Image fusion of MRI and CEUS gives a significant improvement for reliable differentiation between different tumor tissue areas and simplifies investigations by showing the morphology as well as surrounding macro-\/microvascularization.<\/jats:p>\n <\/jats:sec>","DOI":"10.3233\/ch-151986","type":"journal-article","created":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T11:05:52Z","timestamp":1446807952000},"page":"143-150","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of multimodality imaging using image fusion with MRI and CEUS in an experimental animal model"],"prefix":"10.1177","volume":"61","author":[{"given":"P.M.","family":"Paprottka","sequence":"first","affiliation":[{"name":"Institute for Clinical Radiology, Ludwig Maximilian University Hospital, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Zengel","sequence":"additional","affiliation":[{"name":"Institute for Ear, Nose and Throat Medicine, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.C.","family":"Cyran","sequence":"additional","affiliation":[{"name":"Institute for Clinical Radiology, Ludwig Maximilian University Hospital, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.J.","family":"Paprottka","sequence":"additional","affiliation":[{"name":"Institute for Clinical Radiology, Ludwig Maximilian University Hospital, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ingrisch","sequence":"additional","affiliation":[{"name":"Institute for Clinical Radiology, Ludwig Maximilian University Hospital, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Nikolaou","sequence":"additional","affiliation":[{"name":"Institute for Clinical Radiology, Ludwig Maximilian University Hospital, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.F.","family":"Reiser","sequence":"additional","affiliation":[{"name":"Institute for Clinical Radiology, Ludwig Maximilian University Hospital, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.A.","family":"Clevert","sequence":"additional","affiliation":[{"name":"Institute for Clinical Radiology, Ludwig Maximilian University Hospital, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,9,5]]},"reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.1016\/S1076-6332(03)80204-0"},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.107.045922"},{"key":"r3","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20787"},{"key":"r4","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.11.6951"},{"key":"r5","doi-asserted-by":"crossref","unstructured":"De Visschere R., Oosterlinck W., De Meerleer G.2010Clinical and imaging tools in the early diagnosis of prostate cancer, a reviewJBR-BTR936270","DOI":"10.5334\/jbr-btr.121"},{"key":"r6","doi-asserted-by":"publisher","DOI":"10.3233\/CH-141877"},{"key":"r7","doi-asserted-by":"publisher","DOI":"10.3233\/CH-141873"},{"key":"r8","doi-asserted-by":"crossref","unstructured":"Greis C.2004Technology overview: SonoVue (Bracco, Milan)European Radiology14Suppl 8P11P15","DOI":"10.1007\/s10406-004-0076-3"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-33285"},{"key":"r10","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2010.03.004"},{"key":"r11","doi-asserted-by":"publisher","DOI":"10.1007\/s003300101022"},{"key":"r12","unstructured":"Miles K.A.2010Molecular imaging with dynamic contrast-enhanced computed tomography65549556"},{"key":"r13","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2008.06.006"},{"key":"r14","doi-asserted-by":"crossref","unstructured":"Wein W., Khamene A., Clevert D.A.2007Simulation and fully automatic multimodal registration of medical ultrasoundMedical image computing and computer-assisted intervention: MICCAI International Conference on Medical Image Computing and Computer-Assisted Intervention10136143","DOI":"10.1007\/978-3-540-75757-3_17"},{"key":"r15","doi-asserted-by":"publisher","DOI":"10.3233\/CH-141830"},{"key":"r16","unstructured":"Wollenberg B., Ollesch A., Maag K.1994Micrometastases in bone marrow of patients with cancers in the head and neck area738893Laryngorhinootologie"},{"key":"r17","doi-asserted-by":"publisher","DOI":"10.1021\/mp900153f"}],"container-title":["Clinical Hemorheology and Microcirculation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/CH-151986","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/CH-151986","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/CH-151986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:05:36Z","timestamp":1777388736000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/CH-151986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,5]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,9,5]]}},"alternative-id":["10.3233\/CH-151986"],"URL":"https:\/\/doi.org\/10.3233\/ch-151986","relation":{},"ISSN":["1386-0291","1875-8622"],"issn-type":[{"value":"1386-0291","type":"print"},{"value":"1875-8622","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,5]]}}}