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During the cultivation period of three weeks, EC ang ran through all stages of angiogenesis starting from proliferation to migration up to the formation of three-dimensional capillary-like structures. Despite of expression of endothelial markers, EC non-ang showed excessive intracellular storage of lipids in form of multilamellar bodies and decreased angiogenic potency in contrast to its counterpart, EC ang. Results indicate that lipid metabolism differs in EC ang versus EC non-ang. This study points up that these differences are based on the different donors and presents a novel and valuable model for the study of mechanisms of atherosclerosis in endothelial cells in vitro.<\/jats:p>","DOI":"10.3233\/ch-152002","type":"journal-article","created":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T11:07:35Z","timestamp":1446808055000},"page":"367-383","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Human microvascular endothelial cells displaying reduced angiogenesis and increased uptake of lipids during\n                    <i>in vitro<\/i>\n                    culture"],"prefix":"10.1177","volume":"61","author":[{"given":"Henrieke","family":"Sievers","sequence":"first","affiliation":[{"name":"Institute of Veterinary Anatomy, Department of Veterinary Medicine, Freie Universit\u00e4t Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth M.","family":"Hirschberg","sequence":"additional","affiliation":[{"name":"SFB 1112, Institute of Chemistry and Biochemistry - 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