{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:16:07Z","timestamp":1777497367282,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T00:00:00Z","timestamp":1466640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2017,2,27]]},"abstract":"<jats:p>While a number of studies have shown short-term beneficial effects of therapeutic plasma exchange (TPE) for treating systemic scleroderma (SSc), there have been no reports on the very long-term usage of TPE as the sole systemic treatment intervention. We report the case of a male patient, originally diagnosed with limited systemic scleroderma (lcSSc) in early 1990, who has been undergoing regular plasmapheresis treatments for more than 22 years, beginning in late 1993. Prior to commencing treatment, the patient exhibited symptoms including severe gastro esophageal reflux disease (GERD) with esophagitis, frequent Raynaud\u2019s attacks, reduced lung function, and chronic chilling. With the exception of mild residual Raynaud\u2019s, all of the patient\u2019s symptoms reversed after three years of regular TPE treatments and he remains in complete remission. While the typical explanation for the therapeutic benefits seen with TPE focuses on temporary reduction of circulating antibodies or other pathogenic factors, we propose instead an explanation based on abnormal blood rheology as a novel disease pathogenesis model for SSc.<\/jats:p>","DOI":"10.3233\/ch-16140","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T11:08:47Z","timestamp":1488280127000},"page":"131-136","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Successful long-term (22 year) treatment of\u00a0limited scleroderma using therapeutic plasma exchange: Is blood rheology the\u00a0key?"],"prefix":"10.1177","volume":"65","author":[{"given":"Edward S.","family":"Harris","sequence":"first","affiliation":[{"name":"Scleroderma Education Project Ltd, Madison, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert 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