{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:16:04Z","timestamp":1777497364957,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T00:00:00Z","timestamp":1466640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2017,2,27]]},"abstract":"<jats:p>Dialysis patients present a cardiovascular risk substantially higher than general population, due to both traditional and non-traditional risk factors. Hemorheologic alterations have been extensively described in hemodialysis patients (HD), while little data on hemorheology exist about peritoneal dialysis patients (PD). Aim of our study is to characterize the hemorheological profile of 49 PD, and to compare these data with HD and healthy volunteers. PD showed an improvement of parameters related to macro-circulation (plasma viscosity, whole blood viscosity at 1-Hz, erythrocyte aggregation index and yield stress) when compared to HD, while microcirculatory function resulted severely impaired, as expressed by high values for whole blood viscosity 200-Hz shear rate and lower erythrocyte deformability (ED). In conclusion, we found hemorheologic alterations in PD, with substantial differences with respect to HD; in particular, PD showed profound dysfunction in microcirculatory flow with impaired ED. This alterations may act as a risk factor for accelerated atherosclerosis and precipitate cardiovascular events, and it may have a detrimental effect in the peritoneal microcirculation promoting endothelial activation with subsequent fibrosis, leading to peritoneal membrane malfunctioning.<\/jats:p>","DOI":"10.3233\/ch-16152","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T11:09:21Z","timestamp":1488280161000},"page":"175-183","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Hemorheologic alterations in peritoneal dialysis"],"prefix":"10.1177","volume":"65","author":[{"given":"Francesco","family":"Fontana","sequence":"first","affiliation":[{"name":"Surgical, Medical and Dental Department of Morphological\r          Sciences, Section of Nephrology, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Ballestri","sequence":"additional","affiliation":[{"name":"Divisione di Nefrologia, Dialisi e Trapianto Renale,\r          Dipartimento di Medicina e Specialit\u00e1 Mediche, Policlinico di Modena, Modena,\r            Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarisse","family":"Makomi","sequence":"additional","affiliation":[{"name":"Surgical, Medical and Dental Department of Morphological\r          Sciences, Section of Nephrology, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Morandi","sequence":"additional","affiliation":[{"name":"Department of Oncology and Haematology, Section of\r          Transfusion Medicine, University of Modena and Reggio Emilia,\r          Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianni","family":"Cappelli","sequence":"additional","affiliation":[{"name":"Surgical, Medical and Dental Department of Morphological\r          Sciences, Section of Nephrology, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,6,23]]},"reference":[{"issue":"3","key":"ref001","first-page":"411","volume":"34","author":"Brimble K.S.","year":"2006","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2010.00496.x"},{"issue":"1","key":"ref003","first-page":"51","volume":"62","author":"Cianciolo G.","year":"2010","journal-title":"Minerva Urol E Nefrol Ital J Urol Nephrol"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.00180.x"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1281734"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.3233\/BIR-1977-145-605"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.3233\/CH-151967"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)70121-X"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1038\/nm0603-669"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.3233\/CH-152036"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2015(09)01"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1177\/089686089601601S46"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.54.2763"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.3233\/CH-131768"},{"issue":"1","key":"ref015","first-page":"1","volume":"21","author":"Mart\u00ednez M.","year":"1999","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1159\/000045664"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.352"},{"key":"ref018","first-page":"470","volume":"5","author":"Moinuddin Z.","year":"2014","journal-title":"Front Physiol"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1071606"},{"issue":"6","key":"ref020","first-page":"11","volume":"28","author":"del Peso G.","year":"2008","journal-title":"Nefrol Publ of Soc Esp Nefrol"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.3233\/CH-131771"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.3233\/CH-131675"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1177\/089686089601600416"},{"issue":"6","key":"ref024","first-page":"1675","volume":"21","author":"Sherif A.M.","year":"2006","journal-title":"Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc - Eur Ren Assoc"},{"issue":"2","key":"ref025","first-page":"115","volume":"19","author":"Shi Y.D.","year":"1998","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref026","unstructured":"StoltzJ., SinghM.           and RihaP.             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