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Recent works have\n          shown that patients with the lowest RBC deformability (measured by ektacytometry) have\n          enhanced hemolysis and would be more prone to develop several complications such as\n          priapism, leg ulcers and glomerulopathy. In contrast, patients with the highest\n          deformability, and not under hydroxyurea therapy, seem to develop more frequently\n          vaso-occlusive like events. Although less studied, RBC aggregation properties are very\n          different between SCA and healthy individuals and it was demonstrated that increased RBC\n          aggregates strength could be involved in some complications. Finally, several studies have\n          established that the vascular system of SCA patients could not fully compensate any\n          increase in blood viscosity because of the loss of vascular reactivity, which may result\n          in vaso-occlusive crises.<\/jats:p>","DOI":"10.3233\/ch-189005","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T10:16:30Z","timestamp":1522404990000},"page":"165-172","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":52,"title":["Blood rheological abnormalities in sickle cell anemia"],"prefix":"10.1177","volume":"68","author":[{"given":"Philippe","family":"Connes","sequence":"first","affiliation":[{"name":"University of Lyon","place":["France"]},{"name":"Laboratory of Excellence GR-Ex \u00ab The red cell: from genesis\r          to death \u00bb, PRES Sorbonne Paris Cit\u00e9, 75015, Paris, France"},{"name":"Institut Universitaire de France, Paris,\r            France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Renoux","sequence":"additional","affiliation":[{"name":"University of Lyon","place":["France"]},{"name":"Laboratory of Excellence GR-Ex \u00ab The red cell: from genesis\r          to death \u00bb, PRES Sorbonne Paris Cit\u00e9, 75015, Paris, France"},{"name":"Centre de Biologie Est","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Romana","sequence":"additional","affiliation":[{"name":"Laboratory of Excellence GR-Ex \u00ab The red cell: from genesis\r          to death \u00bb, PRES Sorbonne Paris Cit\u00e9, 75015, Paris, France"},{"name":"Inserm UMR 1134, H\u00f4pital Ricou, CHU de Pointe-\u00e0-Pitre, 97157\r          Pointe-\u00e0-Pitre, Guadeloupe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manouk","family":"Abkarian","sequence":"additional","affiliation":[{"name":"Centre de Biochimie Structurale","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Joly","sequence":"additional","affiliation":[{"name":"University of Lyon","place":["France"]},{"name":"Laboratory of Excellence GR-Ex \u00ab The red cell: from genesis\r          to death \u00bb, PRES Sorbonne Paris Cit\u00e9, 75015, Paris, France"},{"name":"Centre de Biologie Est","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Martin","sequence":"additional","affiliation":[{"name":"University of Lyon","place":["France"]},{"name":"Laboratory of Excellence GR-Ex \u00ab The red cell: from genesis\r          to death \u00bb, PRES Sorbonne Paris Cit\u00e9, 75015, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Dominique","family":"Hardy-Dessources","sequence":"additional","affiliation":[{"name":"Laboratory of Excellence GR-Ex \u00ab The red cell: from genesis\r          to death \u00bb, PRES Sorbonne Paris Cit\u00e9, 75015, Paris, France"},{"name":"Inserm UMR 1134, H\u00f4pital Ricou, CHU de Pointe-\u00e0-Pitre, 97157\r          Pointe-\u00e0-Pitre, Guadeloupe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir K.","family":"Ballas","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,3,28]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162652"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.3233\/CH-2009-1167"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830360211"},{"key":"e_1_3_1_5_2","unstructured":"BallasSK Sickle Cell Pain. 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