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Thus, sickle cell disease is a hemorheologic disease that results in various pathologic processes involving multiple organ systems including the lungs, heart, kidneys and brain. Red blood cell mechanics and the perturbations on blood flow-endothelial interaction underlie much of the pathology found in sickle cell disease. Transfusion therapy is one of the few therapeutic options available to patients, acting as both primary and secondary prevention of stroke. Transfusion therapy, both simple and exchange, is also used for unremitting and frequent pain crises and pulmonary hypertension. Therefore, understanding basic rheologic changes following transfusion inform other therapeutic options that aim to mitigate this diffuse pathologic process. This review will aim to highlight transfusion effects on blood rheology.<\/jats:p>","DOI":"10.3233\/ch-189006","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T10:16:12Z","timestamp":1522404972000},"page":"173-186","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Simple chronic transfusion therapy, a crucial therapeutic option for sickle cell disease, improves but does not normalize blood rheology: What should be our goals for transfusion therapy?"],"prefix":"10.1177","volume":"68","author":[{"given":"Jon A.","family":"Detterich","sequence":"first","affiliation":[{"name":"University of Southern California Keck School of Medicine","place":["USA"]},{"name":"University of Southern California Keck School of Medicine","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,3,28]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199608000-00023"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-2456(97)00099-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807023390102"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199023000-00005"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00823.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0650212"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1963.03620270012003"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.29.3.267"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2011.610477"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2011.610478"},{"key":"e_1_3_2_12_2","first-page":"463","article-title":"Is sickle cell disease a hematologic disorder?","volume":"104","author":"Ballas SK","year":"2012","unstructured":"BallasSK. 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