{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:25:20Z","timestamp":1777497920099,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T00:00:00Z","timestamp":1545004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2019,4,4]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Radiologic imaging, especially ultrasound has an important role in the assessment of gallbladder alteration. Contrast-enhanced ultrasound (CEUS) is an easy and fast imaging technique that overcomes the limitations of greyscale ultrasonography. It is a safe tool that can be used as an additional imaging modality in order to elucidate and differentiate gallbladder pathological findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>The aim of this retrospective study analysis is to assess the diagnostic performance of CEUS in gallbladder alterations and compare the results to the histopathological findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      A total of 17 patients between 2009 and 2017 with uncertain gallbladder appearance were retrospectively analysed. A single experienced physician with more than fifteen years\u2019 experience performed CEUS examinations by applying a second-generation blood pool agent (SonoVue\n                      <jats:sup>\u00ae<\/jats:sup>\n                      , Bracco, Milan, Italy). Archived images were interpreted by the same physician and compared to the histopathological findings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>CEUS results, when correlated to the respectively pathologic findings, presented a sensitivity of 100%, a specificity of 100%, a positive predictive value (PPV) of 100% and a negative predictive value (NPV) of 100%. All patients were successfully examined without any adverse reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>In conclusion, the excellent results in this study acknowledged that CEUS is a feasible alternative tool to differentiate gallbladder pathologic alterations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/ch-189405","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T12:39:48Z","timestamp":1545136788000},"page":"151-158","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Contrast-enhanced ultrasound (CEUS) and gallbladder diseases - A retrospective mono-center analysis of imaging findings with histopathological correlation"],"prefix":"10.1177","volume":"71","author":[{"given":"G.","family":"Negr\u00e3o de Figueiredo","sequence":"first","affiliation":[{"name":"Department of Radiology, Interdisciplinary Ultrasound-Center Ludwig-Maximilians-University of Munich - Grosshadern Campus, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Mueller-Peltzer","sequence":"additional","affiliation":[{"name":"Department of Radiology, Interdisciplinary Ultrasound-Center Ludwig-Maximilians-University of Munich - Grosshadern Campus, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Zengel","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Armbruster","sequence":"additional","affiliation":[{"name":"Department of Radiology, Interdisciplinary Ultrasound-Center Ludwig-Maximilians-University of Munich - Grosshadern Campus, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"R\u00fcbenthaler","sequence":"additional","affiliation":[{"name":"Department of Radiology, Interdisciplinary Ultrasound-Center Ludwig-Maximilians-University of Munich - Grosshadern Campus, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.A.","family":"Clevert","sequence":"additional","affiliation":[{"name":"Department of Radiology, Interdisciplinary Ultrasound-Center Ludwig-Maximilians-University of Munich - Grosshadern Campus, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,12,17]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1007\/s00117-017-0225-z"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-104646"},{"issue":"3","key":"ref003","first-page":"383","volume":"17","author":"Badea R","year":"2015","journal-title":"The importance of correlation between imaging methods and patients\u2019 signs and symptoms. Med Ultrason"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-009-0507-3"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2006.05.031"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.3233\/CH-168034"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2007.26.6.763"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1007\/s10406-005-0170-1"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.11152\/mu-1090"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.3233\/CH-189116"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.3233\/CH-162058"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007463"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-108207"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.14366\/usg.16027"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12404"},{"issue":"4","key":"ref016","first-page":"326","volume":"14","author":"Sparchez Z","year":"2012","journal-title":"Med Ultrason"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.11152\/mu.2013.2066.183.wei"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-009-1538-8"},{"issue":"6","key":"ref019","first-page":"790","volume":"104","author":"Hattori M","year":"2007","journal-title":"Nihon Shokakibyo Gakkai Zasshi"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(98)70012-4"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.21.2.g01mr16295"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1155\/2002\/787598"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1148\/rg.352140095"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-107995"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016161042"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/60619911"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2271011378"}],"container-title":["Clinical Hemorheology and Microcirculation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/CH-189405","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/CH-189405","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/CH-189405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:07:25Z","timestamp":1777388845000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/CH-189405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,17]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4,4]]}},"alternative-id":["10.3233\/CH-189405"],"URL":"https:\/\/doi.org\/10.3233\/ch-189405","relation":{},"ISSN":["1386-0291","1875-8622"],"issn-type":[{"value":"1386-0291","type":"print"},{"value":"1875-8622","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,17]]}}}