{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:08:09Z","timestamp":1777496889354,"version":"3.51.4"},"reference-count":71,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CH"],"published-print":{"date-parts":[[2021,12,27]]},"abstract":"<jats:p>The complement system is an essential component of the innate immune defence that, if overly activated, may damage organs and tissues. For this reason, there is a fine complement regulatory system. The complement modulation system includes two proteins with important regulatory activity, CD55 or decay accelerating factor (DAF) and CD59 or membrane inhibitor of reactive lysis (MIRL). The paroxysmal nocturnal hemoglobinuria (PNH) is a clonal and non-neoplastic disease characterized by intravascular haemolysis, occurrence of thrombosis and bone marrow failure. In clinical practice, in opposition to PNH, a variety of pathological conditions have been observed with an acquired and non-genetic deficiency of the regulatory proteins CD55 and CD59. This abnormal, non-clonal, reduced expression of complement regulatory proteins configures what we may define as PNH-like phenotype. Similarly to PNH, even in the PNH-like phenotype diseases there has been a greater exposure to the mediated complement cellular lysis and, a likely increased risk of thromboembolic events. Therefore, the knowledge of the potential roles of the complement system becomes necessary for a deeper understanding of several pathological conditions and for an improved clinical management of the patients.<\/jats:p>","DOI":"10.3233\/ch-190735","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T11:18:41Z","timestamp":1582629521000},"page":"491-503","source":"Crossref","is-referenced-by-count":1,"title":["Thrombotic risk in paroxysmal nocturnal hemoglobinuria-like (PNH-like) phenotype"],"prefix":"10.1177","volume":"79","author":[{"given":"Melania","family":"Carlisi","sequence":"first","affiliation":[{"name":"Department of Surgical, Oncological and Stomatological Disciplines, University of Palermo, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatrice","family":"Mancuso","sequence":"additional","affiliation":[{"name":"Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties 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