{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:08:52Z","timestamp":1790485732970,"version":"4.1.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CH"],"published-print":{"date-parts":[[2020,9,25]]},"abstract":"<jats:p>INTRODUCTION: Neointima formation is closely linked to vascular stenosis and occurs after endothelial damage. Hydrogen sulfide is an endogenous pleiotropic mediator with numerous positive effects on the cardio vascular system. OBJECTIVE: This study evaluates the effect of the slow releasing hydrogen sulfide donor GYY4137 (GYY) on neointimal formation in vivo. METHODS: The effect of GYY on neointimal formation in the carotid artery was studied in the FeCl3 injury model in GYY- or vehicle-treated mice. The carotid arteries were studied at days 7 and 21 after treatment by means of histology and immunohistochemistry for proliferating cell nuclear antigen (PCNA) and alpha smooth muscle actin (\u03b1-SMA). RESULTS: GYY treatment significantly reduced the maximal diameter and the area of the newly formed neointima on both days 7 and 21 when compared to vehicle treatment. GYY additionally reduced the number of PCNA- and \u03b1-SMA-positive cells within the neointima on day 21 after FeCl3 injury of the carotid artery. CONCLUSIONS: Summarizing, single treatment with the slow releasing hydrogen sulfide donor GYY reduced the extent of the newly formed neointima by affecting the cellular proliferation at the site of vascular injury.<\/jats:p>","DOI":"10.3233\/ch-190747","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T09:16:45Z","timestamp":1579252605000},"page":"409-417","source":"Crossref","is-referenced-by-count":2,"title":["The slow releasing hydrogen sulfide donor GYY4137 reduces neointima formation upon FeCl3 injury of the carotid artery in\u00a0mice"],"prefix":"10.1177","volume":"75","author":[{"given":"Eberhard","family":"Grambow","sequence":"first","affiliation":[{"name":"Institute for Experimental Surgery, Rostock University Medical Center, Rostock, Germany"},{"name":"Department of General, Visceral, Vascular and Transplantation Surgery, Rostock University Medical Center, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Klee","sequence":"additional","affiliation":[{"name":"Institute for Experimental Surgery, Rostock University Medical Center, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst","family":"Klar","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, Vascular and Transplantation Surgery, Rostock University Medical Center, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Vollmar","sequence":"additional","affiliation":[{"name":"Institute for Experimental Surgery, Rostock University Medical Center, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"issue":"1","key":"10.3233\/CH-190747_ref1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3233\/CH-180429","article-title":"Timing of clopidogrel loading dose on peripheral blood 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