{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:07:03Z","timestamp":1777496823221,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CH"],"published-print":{"date-parts":[[2021,2,12]]},"abstract":"<jats:p>BACKGROUND: Major burn injury causes massive tissue destruction consequently enhanced platelet function and leukocyte-mediated inflammatory response. METHODS: In a prospective, observational study 23 consecutive patients with more than 20% body surface burn injury were followed for five days (T1\u2013T5) after admission to a university intensive care (ICU). Platelet and leukocyte antisedimentation rate (PAR and LAR) was measured by one-hour gravity sedimentation. It detects the percentage of total platelet and leukocyte number crossed the half line of blood sample column, therefore, they can be regarded as cells of decreased specific gravity. We aimed to investigate the time course of PAR and LAR after burn injury, as the trend of platelet and the leukocyte activation in the early post-burn period. RESULTS: Daily mean PAR and LAR values continuously increased in the observation period (T1 to T5). Daily mean PAR and LAR were lower in ICU non-survivors (n\u200a=\u200a7) compared to survivors (n\u200a=\u200a16) between T2 and T4 (p\u200a&lt;\u200a0.05 and p\u200a&lt;\u200a0.01). PAR values of septic patients (n\u200a=\u200a10) were lower than that of non-septic ones (n\u200a=\u200a13, p\u200a&lt;\u200a0.01 at T5). CONCLUSIONS: Both PAR and LAR, as novel bedside test can predict septic complications and unfavorable outcome after major burn injury. Further studies with higher sample size are warranted.<\/jats:p>","DOI":"10.3233\/ch-190779","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T12:30:15Z","timestamp":1591705815000},"page":"17-26","source":"Crossref","is-referenced-by-count":6,"title":["Lack of early platelet and leukocyte activation can indicate complications after major burn injury"],"prefix":"10.1177","volume":"77","author":[{"given":"Csaba","family":"Loibl","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, University of P\u00e9cs Medical School, P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Rozanovic","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, University of P\u00e9cs Medical School, P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lajos","family":"Bog\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, University of P\u00e9cs Medical School, P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Pankaczi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, University of P\u00e9cs Medical School, P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, University of P\u00e9cs Medical School, P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Miseta","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of P\u00e9cs Medical School, P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiham\u00e9r","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, University of P\u00e9cs Medical School, P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csaba","family":"Csontos","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, University of P\u00e9cs Medical School, P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"34","key":"10.3233\/CH-190779_ref1","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1007\/s00134-007-0976-5","article-title":"Early coagulation disorders after severe burn injury: impact on mortality","author":"Lavrentieva","year":"2008","journal-title":"Intensive Care Med"},{"issue":"33","key":"10.3233\/CH-190779_ref2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/00005373-199207000-00011","article-title":"The effect of burn wound size on hemostasis: a correlation of the hemostatic changes to the clinical state","author":"Kowal-Vern","year":"1992","journal-title":"J Trauma"},{"issue":"39","key":"10.3233\/CH-190779_ref3","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.burns.2013.02.010","article-title":"Acute burn induced coagulopathy","author":"Sherren","year":"2013","journal-title":"Burns"},{"issue":"39","key":"10.3233\/CH-190779_ref4","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/SHK.0b013e31828e08cb","article-title":"Early coagulopathy is an independent predictor of mortality in children after severe trauma","author":"Whittaker","year":"2013","journal-title":"Shock"},{"issue":"32","key":"10.3233\/CH-190779_ref5","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/BCR.0b013e318217f91b","article-title":"Thrombocytopenia in the pediatric burn patient","author":"Warner","year":"2011","journal-title":"J Burn Care Res"},{"issue":"39","key":"10.3233\/CH-190779_ref6","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.burns.2013.01.015","article-title":"Time course of thrombocytes in burn patients and its predictive value for outcome","author":"Marck","year":"2013","journal-title":"Burns"},{"issue":"107","key":"10.3233\/CH-190779_ref7","doi-asserted-by":"crossref","first-page":"4399","DOI":"10.1182\/blood-2005-09-3776","article-title":"Platelet depletion in mice increases mortality after thermal injury","author":"Fujimi","year":"2006","journal-title":"Blood"},{"issue":"44","key":"10.3233\/CH-190779_ref8","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.burns.2017.08.015","article-title":"Platelet count: A predictor of sepsis and mortality in severe burns","author":"Cato","year":"2018","journal-title":"Burns"},{"key":"10.3233\/CH-190779_ref9","doi-asserted-by":"crossref","unstructured":"Dewitte A , Lepreux S , Villeneuve J , Rigothier C , Combe C , et al. 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