{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:27:37Z","timestamp":1777498057718,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2020,9,25]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>High surgical risk patients presenting with severe mitral valve regurgitation (MR) and concomitant aortic valve disease are frequently a challenge for the interdisciplinary heart team meeting. If open-heart surgery for severe MR is performed, aortic stenosis (AS) or regurgitation (AR) is corrected during the same procedure if at least moderate severity of AS or AR has been confirmed. In patients with prohibitive surgical risk, optimal management strategies in the light of available transcatheter interventions still needs to be established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>METHODS AND RESULTS:<\/jats:title>\n                    <jats:p>\n                      In this retrospective single center study, we aimed to investigate the impact of coincident moderate aortic valve disease on the outcome of patients undergoing MitraClip for severe MR. In 286 MitraClip procedures performed in our institution, 21 patients (7,3%) were identified to suffer from concomitant moderate AS and 28 patients had moderate AR (9,8%). Patients with AS were found to have a higher incidence of &gt;moderate MR following the procedure when compared to patients without aortic valve disease (14,3% vs. 8,9%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.001). No differences between the groups were found regarding a combined endpoint of all cause deaths and heart failure hospitalizations after 1 year follow up (no aortic-valve disease vs. moderate AS: 19% vs 18%;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0,881 and no aortic valve disease vs moderate AR: 19% vs. 25%;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.477). However, mortality was significantly higher in patients with coincidental moderate AR (3.8% patients without aortic valve disease, 5% in patients with AS, 17,9% in patients with AR;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>According to our analysis coincidental Aortic valve stenosis may be associated with worse technical results regarding residual MR after MitraClip. Although our results regarding a combined endpoint of all-cause mortality and heart failure hospitalizations within one year of follow up were comparable between the groups, patients with moderate AR had significantly higher mortality rates. Due to the limited number of patients, our study is only hypothesis generating. Larger trials are necessary to confirm our result.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/ch-200818","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T10:49:44Z","timestamp":1588675784000},"page":"447-455","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The impact of moderate Aortic Valve Disease in patients undergoing MitraClip for severe MR"],"prefix":"10.1177","volume":"75","author":[{"given":"Haitham Saleh Ali","family":"Al-Hindwan","sequence":"first","affiliation":[{"name":"Department of Cardiology, Charit\u00e9 Berlin, Campus Benjamin Franklin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnther","family":"Silbernagel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Charit\u00e9 Berlin, Campus Benjamin Franklin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Curio","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Charit\u00e9 Berlin, Campus Benjamin Franklin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Abulgasim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Charit\u00e9 Berlin, Campus Benjamin Franklin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Schr\u00f6der","sequence":"additional","affiliation":[{"name":"Institute of Biomaterial Science","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imke","family":"Wuerdemann","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Charit\u00e9 Berlin, Campus Benjamin Franklin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Kasner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Charit\u00e9 Berlin, Campus Benjamin Franklin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Landmesser","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Charit\u00e9 Berlin, Campus Benjamin Franklin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Reinthaler","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Charit\u00e9 Berlin, Campus Benjamin Franklin, Berlin, Germany"},{"name":"Institute of Biomaterial Science","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00201-X"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69208-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2009.165548rep"},{"issue":"9","key":"e_1_3_2_5_2","first-page":"I443","article-title":"Aortic valve replacement and concomitant mitral valve regurgitation in the elderly: impact on survival and functional outcome","volume":"112","author":"Barreiro CJ","year":"2005","unstructured":"BarreiroCJ, PatelND, FittonTP, WilliamsJA, BondePN, ChanV, et al. Aortic valve replacement and concomitant mitral valve regurgitation in the elderly: impact on survival and functional outcome. Circulation. 2005;112(9 Suppl):I443\u20137.","journal-title":"Circulation"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0886-0440.2004.00362.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000029"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx391"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009355"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.018"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806640"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3233\/CH-189906"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.02.020"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805374"},{"issue":"1","key":"e_1_3_2_15_2","first-page":"18","article-title":"The MitraClip System: a systematic review of indications, procedural requirements, and guidelines","volume":"62","author":"Bail DH","year":"2014","unstructured":"BailDH, DoeblerK. The MitraClip System: a systematic review of indications, procedural requirements, and guidelines. Thorac Cardiovasc Surg. 2014;62(1):18\u201325.","journal-title":"Thorac Cardiovasc Surg"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-013-0614-x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.02.009"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(03)00335-3"},{"issue":"3","key":"e_1_3_2_19_2","first-page":"376","article-title":"How to measure severity of mitral regurgitation: valvular heart disease","volume":"94","author":"Grayburn PA","year":"2008","unstructured":"GrayburnPA. How to measure severity of mitral regurgitation: valvular heart disease. 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