{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:29:50Z","timestamp":1777498190250,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"2-4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p>Hemorheological abnormalities such as elevated whole blood viscosity, plasma viscosity, erythrocyte deformability and platelet aggregation, hematocrit and fibrinogen levels, are frequently examined as diagnostic tool and prognostic relevance in socially important hemorheological disorders. Distinct biological \u2013 morphological and functional platelet alterations, have been described in different addictions (heroin-, cocaine-, nicotine-, alcohol-, etc.). Chronic addictions could cause biochemical and conformational changes in platelets and their membranes, thus modulating platelet receptor expression, morphology (anisocytosis, giant platelets) and activation (alpha-granule release), platelet aggregation and hemorheological properties. Some of these alterations in chronic addicts \u2013 documented at cellular- and molecular level, could be easily used as a precise diagnostic tool with regard to thromboembolic complications and microcirulation injuries attributable to addictions. The present review focuses on some changes in platelet morphological, functional and rheological properties induced by chronic opiate\/opioid abuse. Hypothesis is accumulated that free fatty acids (FFAs) and especially oleic acid (OA) could cause positive molecular and conformational changes in platelets of addicts with hemorheological disorders.<\/jats:p>","DOI":"10.3233\/ch-2010-1305","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T13:03:58Z","timestamp":1575291838000},"page":"245-251","source":"Crossref","is-referenced-by-count":13,"title":["Platelet morphological, functional and rheological properties attributable to addictions"],"prefix":"10.1177","volume":"45","author":[{"given":"Elissaveta","family":"Zvetkova","sequence":"first","affiliation":[{"name":"Bulgarian Society of Biorheology, Bulgarian Academy of Sciences, Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Antonova","sequence":"additional","affiliation":[{"name":"Bulgarian Society of Biorheology, Bulgarian Academy of Sciences, Sofia, Bulgaria"},{"name":"Institute of Mechanics and Biomechanics, Bulgarian Academy of Sciences, Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Ivanov","sequence":"additional","affiliation":[{"name":"Bulgarian Society of Biorheology, Bulgarian Academy of Sciences, Sofia, Bulgaria"},{"name":"Institute of Mechanics and Biomechanics, Bulgarian Academy of Sciences, Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonko","family":"Savov","sequence":"additional","affiliation":[{"name":"Institute of Experimental Morphology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yordanka","family":"Gluhcheva","sequence":"additional","affiliation":[{"name":"Institute of Experimental Morphology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,1]]},"container-title":["Clinical Hemorheology and Microcirculation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/CH-2010-1305","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/CH-2010-1305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:08:41Z","timestamp":1777388921000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/CH-2010-1305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":0,"journal-issue":{"issue":"2-4","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.3233\/CH-2010-1305"],"URL":"https:\/\/doi.org\/10.3233\/ch-2010-1305","relation":{},"ISSN":["1386-0291","1875-8622"],"issn-type":[{"value":"1386-0291","type":"print"},{"value":"1875-8622","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}