{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:31:49Z","timestamp":1777498309946,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>Hyperhomocysteinemia (HH) and metabolic syndrome (MS) are associated with increased cardiovascular risk. However, whether there is a link between MS or its components and homocysteine levels in a population without cardiovascular disease is not well established. We conducted a case-control study in 61 MS patients (41 males, 20 females, aged 51 \u00b1 11 years) and in 98 controls without MS (59 males, 39 females, aged 50 \u00b1 10 years) to ascertain the association between MS and HH, and with inflammatory markers. MS was classified according to the updated ATPIII criteria [17]. No differences in homocysteine levels were observed when comparing MS patients and controls (12.0 \u00b1 3.18 \u03bcM vs. 11.9 \u00b1 3.5 \u03bcM, p = 0.829). No association was found between HH (homocysteine &gt;15 \u03bcM) and MS, its components (abdominal obesity (p = 0.635), hypertension (0.229), low-HDL cholesterol (p = 0.491), glucose &gt;100 mg\/dL (0.485), hypertriglyceridemia (p = 0.490)) or the number of MS components (p = 272). When considering glucose &gt;110 mg\/dL (NCEP-ATPIII criteria, 2001) instead of glucose intolerancen &gt;100 mg\/dl (updated ATPIII criteria, Grundy, 2005), a borderline association with HH was observed (p = 0.054) of statistical significance (p = 0.008) when glucose &gt;126 mg\/dL was considered. In a multivariate regression model, creatinine, folic acid and vitamin B12 were the only independent predictors of homocysteine levels (p &lt; 0.05). Although MS correlated with inflammatory parameters (fibrinogen, hs-RCP, plasma viscosity and leukocyte count, p &lt; 0.001), no association was found between HH and the above-mentioned parameters (p &gt; 0.05). Our results do not indicate a link between SM or its individual components with HH, and diabetes was the only relevant contribution. Cardiovascular disease risk due to MS and HH seems to share no common mechanisms.<\/jats:p>","DOI":"10.3233\/ch-2010-1366","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T13:05:21Z","timestamp":1575291921000},"page":"59-66","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Homocysteine levels and the metabolic syndrome in a Mediterranean population: A case-control study"],"prefix":"10.1177","volume":"47","author":[{"given":"Amparo","family":"Vay\u00e1","sequence":"first","affiliation":[{"name":"Hemorheology and Hemostasis Unit, Service of Clinical Pathology, La Fe University Hospital, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Carmona","sequence":"additional","affiliation":[{"name":"Hemorheology and Hemostasis Unit, Service of Clinical Pathology, La Fe University Hospital, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Badia","sequence":"additional","affiliation":[{"name":"Hemorheology and Hemostasis Unit, Service of Clinical Pathology, La Fe University Hospital, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Valencian Community Transfusion Center, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Hernandez Mijares","sequence":"additional","affiliation":[{"name":"Endocrinology Service, Doctor Peset University Hospital, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores","family":"Corella","sequence":"additional","affiliation":[{"name":"Epidemiology Service and CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n, School of Medicine, University of Valencia, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,1,1]]},"container-title":["Clinical Hemorheology and Microcirculation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/CH-2010-1366","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/CH-2010-1366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:09:08Z","timestamp":1777388948000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/CH-2010-1366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["10.3233\/CH-2010-1366"],"URL":"https:\/\/doi.org\/10.3233\/ch-2010-1366","relation":{"is-cited-by":[{"id-type":"doi","id":"10.3389\/fendo.2018.00502","asserted-by":"object"}]},"ISSN":["1386-0291","1875-8622"],"issn-type":[{"value":"1386-0291","type":"print"},{"value":"1875-8622","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}