{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:33:27Z","timestamp":1777959207617,"version":"3.51.4"},"reference-count":75,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CH"],"published-print":{"date-parts":[[2021,8,3]]},"abstract":"<jats:p>BACKGROUND: When performing large volume liposuction, perioperative management of lipedema patients with coagulation disorders remains challenging due to a lack of clinical experience. With a prevalence of 1% of von Willebrand disease (VWD) in the general population, basic knowledge on diagnostic and adapted surgical strategies are essential for patients\u2019 safety. OBJECTIVE: Based on a selective literature review, the purpose of this article is to present a standardized algorithm for diagnosis and perioperative treatment of VWD patients undergoing large volume liposuction. METHODS: The databases MEDLINE (via PubMed) and Web of Science were selectively searched with the term \u201c(((liposuction) OR (surgery)) OR (lipectomy)) AND (((VWD) OR (hemostaseology)) OR (von Willebrand disease))\u201d. Included were articles published in English or German until November 2020. RESULTS: The evidence for large volume liposuctions in patients with VWD is limited. Experience is largely based on operations with similar bleeding risks. A safe performance requires an adjustment of the surgical technique and a customized perioperative drug substitution plan. According to the current literature, perioperative thromboembolic events appear to be rare with adequate drug treatment. CONCLUSION: The implementation of the developed diagnostic and treatment algorithm may help further reducing bleeding complications and improve the safety for treated patients.<\/jats:p>","DOI":"10.3233\/ch-201063","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T14:36:57Z","timestamp":1617374217000},"page":"311-324","source":"Crossref","is-referenced-by-count":3,"title":["Management of large volume liposuction in lipedema patients with von Willebrand disease: A systematic review and treatment algorithm"],"prefix":"10.1177","volume":"78","author":[{"given":"Jeremias","family":"Schmidt","sequence":"first","affiliation":[{"name":"Department of Plastic, Aesthetic and Reconstructive Microsurgery\/ Hand surgery, Hospital Ernst von Bergmann Clinic Potsdam, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Kruppa","sequence":"additional","affiliation":[{"name":"Department of Plastic, Aesthetic and Reconstructive Microsurgery\/ Hand surgery, Hospital Ernst von Bergmann Clinic Potsdam, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1693-3572","authenticated-orcid":false,"given":"Iakovos","family":"Georgiou","sequence":"additional","affiliation":[{"name":"Department of Plastic, Aesthetic and Reconstructive Microsurgery\/ Hand surgery, Hospital Ernst von Bergmann Clinic Potsdam, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mojtaba","family":"Ghods","sequence":"additional","affiliation":[{"name":"Department of Plastic, Aesthetic and Reconstructive Microsurgery\/ Hand surgery, Hospital Ernst von Bergmann Clinic Potsdam, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"6","key":"10.3233\/CH-201063_ref1","first-page":"400","article-title":"Surgical treatment of lipoedema","volume":"50","author":"Ghods","year":"2018","journal-title":"Handchir Mikrochir Plast Chir"},{"issue":"15","key":"10.3233\/CH-201063_ref3","first-page":"184","article-title":"Lipedema of the legs: a syndrome characterized by fat legs and orthostatic edema","author":"Allen","year":"1940","journal-title":"Proc Staff Mayo Clinic"},{"issue":"6","key":"10.3233\/CH-201063_ref4","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1097\/PRS.0000000000006280","article-title":"New Insights on Lipedema: The Enigmatic Disease of the Peripheral Fat","volume":"144","author":"Bauer","year":"2019","journal-title":"Plastic and Reconstructive Surgery"},{"issue":"9","key":"10.3233\/CH-201063_ref5","doi-asserted-by":"crossref","first-page":"e1043","DOI":"10.1097\/GOX.0000000000001043","article-title":"Lipedema: A Relatively Common Disease with Extremely Common Misconceptions","volume":"4","author":"Buck","year":"2016","journal-title":"Plastic and Reconstructive Surgery Global Open"},{"issue":"3","key":"10.3233\/CH-201063_ref6","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/PRS.0000000000005918","article-title":"Adipose Stem Cells from Lipedema and Control Adipose Tissue Respond Differently to Adipogenic Stimulation In Vitro","volume":"144","author":"Bauer","year":"2019","journal-title":"Plastic and Reconstructive Surgery"},{"issue":"5","key":"10.3233\/CH-201063_ref7","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.mehy.2014.08.011","article-title":"Pathophysiological dilemmas of lipedema","volume":"83","author":"Szel","year":"2014","journal-title":"Medical Hypotheses"},{"issue":"12","key":"10.3233\/CH-201063_ref8","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1111\/j.1600-0560.2009.01256.x","article-title":"Adipose tissue remodeling in lipedema: adipocyte death and concurrent regeneration","volume":"36","author":"Suga","year":"2009","journal-title":"Journal of Cutaneous Pathology"},{"issue":"7","key":"10.3233\/CH-201063_ref9","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.jcyt.2017.03.073","article-title":"The adipose tissue-derived stromal vascular fraction cells from lipedema patients: Are they different?","volume":"19","author":"Priglinger","year":"2017","journal-title":"Cytotherapy"},{"key":"10.3233\/CH-201063_ref10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1155\/2019\/8747461","article-title":"Dilated Blood and Lymphatic Microvessels, Angiogenesis, Increased Macrophages, and Adipocyte Hypertrophy in Lipedema Thigh Skin and Fat Tissue","volume":"2019","author":"AL-Ghadban","year":"2019","journal-title":"J Obes"},{"issue":"12","key":"10.3233\/CH-201063_ref11","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s00105-018-4304-5","article-title":"[Differential diagnostics of lipedema and lymphedema: A practical guideline]","volume":"69","author":"Wollina","year":"2018","journal-title":"Der Hautarzt"},{"key":"10.3233\/CH-201063_ref13","unstructured":"Szolnoky G . 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