{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:39:57Z","timestamp":1777498797118,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"2-4","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>Previous studies from our and other laboratories have demonstrated the existence of a clear relationship between different measures of endothelial function and the extent of coronary atherosclerosis. The relationship between endothelial function and carotid intima-media thickness has not been extensively investigated. Endothelial function using radial artery flow-mediated constriction (L-FMC) and dilation (FMD) was assessed in 513 consecutive patients undergoing diagnostic coronary angiography. Intima-media thickness of both carotid arteries was also measured. IMT was greater in patients with diabetes, males, those with body mass index &gt;30, and in those older than 65 years (all p &lt; 0.05). There was a strong correlation between age and IMT (p &lt; 0.0001). Hypercholesterolemia and a family history for cardiovascular disease had no impact on IMT. In contrast, the relationship between either L-FMC or FMD and IMT was weak at best (p = 0.008 for the relationship between L-FMC and IMT, p = 0.13 for the relationship between FMD and IMT). There was a positive correlation between IMT and resting radial artery diameter (p = 0.008). IMT increased with the extent of coronary artery disease, but this trend did not reach statistical significance (p = 0.07). Resting (L-FMC), but not recruitable (FMD) endothelial function correlates with the extent of subclinical carotid atherosclerosis. This correlation is however weaker in comparison to that with age.<\/jats:p>","DOI":"10.3233\/ch-2012-1601","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T13:13:28Z","timestamp":1575292408000},"page":"235-243","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evidence of a weak correlation between peripheral endothelial function measures and carotid intima-media thickness"],"prefix":"10.1177","volume":"52","author":[{"given":"Sarina","family":"Schaefer","sequence":"first","affiliation":[{"name":"Department of Medicine, University Medical Center Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selina","family":"Muxel","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Medical Center Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Fasola","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Medical Center Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alica","family":"Beutel","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Medical Center Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Forconi","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Medical Center Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Parker","sequence":"additional","affiliation":[{"name":"Mount Sinai and University Health Network Hospitals, Toronto, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"M\u00fcnzel","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Medical Center Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Gori","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Medical Center Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,2,26]]},"container-title":["Clinical Hemorheology and Microcirculation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/CH-2012-1601","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/CH-2012-1601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:10:36Z","timestamp":1777389036000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/CH-2012-1601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":0,"journal-issue":{"issue":"2-4","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.3233\/CH-2012-1601"],"URL":"https:\/\/doi.org\/10.3233\/ch-2012-1601","relation":{},"ISSN":["1386-0291","1875-8622"],"issn-type":[{"value":"1386-0291","type":"print"},{"value":"1875-8622","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}