{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:08:11Z","timestamp":1777496891624,"version":"3.51.4"},"reference-count":79,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CH"],"published-print":{"date-parts":[[2021,11,11]]},"abstract":"<jats:p>OBJECTIVE: The study aims at assessing the relationship between blood pressure, heart geometry parameters, and the erythrocyte content of sulfur, potassium, chlorine and phosphorus, in a group of patients with ambulatory systolic and diastolic blood pressure (SBP, DBP) below 140 or 90\u200amm Hg, respectively, who were otherwise healthy and untreated. METHODS: The study group consisted of 42 adults recruited in a primary care setting. The individuals were healthy, not undergoing any therapy and free from smoking. For each individual, data were obtained on: average 24-hour SBP and DBP, left ventricle geometry, complete blood count, lipids profile, fibrinogen, hs-CRP and the erythrocyte concentration of sulfur (S), potassium (K), chlorine (Cl) and phosphorus (P). RESULTS: Multivariate regression analysis showed statistically significant relationships of diastolic posterior wall thickness (PWTd) and relative wall thickness (RWT) with the concentration ratio of sulfur and potassium (S\/K) in erythrocytes: PWTd and RWT increase as the S\/K ratio increases. Also, SBP was found to be positively correlated with the S\/K ratio. CONCLUSIONS: The increase in sulfur content in RBCs could be an indicator of the downregulation of nitric oxide (NO) erythrocyte bioavailability exerted by endogenously produced hydrogen sulfide (H2S), and, in consequence, a marker of the development of hypertension and\/or adverse changes in heart geometry.<\/jats:p>","DOI":"10.3233\/ch-211117","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T12:38:47Z","timestamp":1621946327000},"page":"279-292","source":"Crossref","is-referenced-by-count":2,"title":["Association of sulfur content in erythrocytes with cardiovascular parameters and blood pressure"],"prefix":"10.1177","volume":"79","author":[{"given":"Maria","family":"Fornal","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janusz","family":"Lekki","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Physics PAN, Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaros\u0142aw","family":"Kr\u00f3lczyk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Wizner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Grodzicki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/CH-211117_ref1","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1136\/bmj.322.7291.912","article-title":"ABC of hypertension: The pathophysiology of hypertension","volume":"322","author":"Beevers","year":"2001","journal-title":"BMJ"},{"issue":"8","key":"10.3233\/CH-211117_ref2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.tig.2012.04.001","article-title":"Genetic basis of blood pressure and hypertension","volume":"28","author":"Padmanabhan","year":"2012","journal-title":"Trends Genet"},{"issue":"6","key":"10.3233\/CH-211117_ref3","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1161\/CIRCRESAHA.116.303647","article-title":"Genetic and molecular aspects of Hypertension","volume":"116","author":"Padmanabhan","year":"2015","journal-title":"Circ Res"},{"issue":"2","key":"10.3233\/CH-211117_ref4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.33549\/physiolres.931913","article-title":"The interaction of genetic and environmental factors in the etiology of hypertension","volume":"58","author":"Kunes","year":"2009","journal-title":"Physiol. 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