{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:12:36Z","timestamp":1777497156393,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CH"],"published-print":{"date-parts":[[2022,2,17]]},"abstract":"<jats:p>BACKGROUND: Rheopheresis is a selective extracorporal double cascade filtration treatment, which can extract high molecular weight proteins being responsible for hyperviscosity. As the whole blood and plasma viscosity decrease microcirculation improves. OBJECTIVE: In this preliminary study we aimed to analyze additional beneficial effects of rheopheresis treatment with changes of pro-inflammantory cytokine levels in diabetic foot syndrome patients. METHODS: Two rheopheresis treatments were performed for 6 patients with diabetic foot ulcer and\/or neuropathy on consecutive days. Before and after the treatments whole blood and plasma viscosity, as well as IL-6, IL-8, and TNF-alpha serum levels were determined, and complex angiological and ENG examinations were performed. RESULTS: Rheopheresis decreased the whole blood and plasma viscosity, and the serum levels of IL-6, IL-8, and TNF-alpha were markedly reduced. The life quality of the patients improved, the ulcers healed, the pain decreased. Daily dose of analgesics decreased in the follow-up period (6 months). The ENG showed improving amplitude and\/or normalizing conduction speed. CONCLUSION: Application of rheopheresis in patients with diabetic foot syndrome has a beneficial effect, providing favorable rheological condition, normalizing cytokine profile and reducing the sensorineural symptoms.<\/jats:p>","DOI":"10.3233\/ch-211188","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T11:36:57Z","timestamp":1635507417000},"page":"117-125","source":"Crossref","is-referenced-by-count":3,"title":["The effect of rheopheresis treatment on the cytokine profile in diabetic foot syndrome with hyperviscosity in the aspect of clinical changes: A preliminary study"],"prefix":"10.1177","volume":"80","author":[{"given":"Kristof","family":"Gal","sequence":"first","affiliation":[{"name":"Division of Angiology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"Veres","sequence":"additional","affiliation":[{"name":"Division of Angiology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e1ndor","family":"Halmi","sequence":"additional","affiliation":[{"name":"Division of Angiology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krisztina","family":"Bozoki-Beke","sequence":"additional","affiliation":[{"name":"Division of Angiology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klara","family":"Fekete","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Homoki","sequence":"additional","affiliation":[{"name":"Department of Food Technology, Faculty of Agricultural and Food Sciences and Environmental Management University of Debrecen, Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Remenyik","sequence":"additional","affiliation":[{"name":"Department of Food Technology, Faculty of Agricultural and Food Sciences and Environmental Management University of Debrecen, Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Barath","sequence":"additional","affiliation":[{"name":"Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Varga","sequence":"additional","affiliation":[{"name":"Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Nemeth","sequence":"additional","affiliation":[{"name":"Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pal","family":"Soltesz","sequence":"additional","affiliation":[{"name":"Division of Angiology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"3","key":"10.3233\/CH-211188_ref1","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3233\/CH-200901","article-title":"Current opinion on the role of the foot perfusion in limbamputation risk assessment","volume":"76","author":"Martini","year":"2020","journal-title":"Clin Hemorheol Microcirc"},{"key":"10.3233\/CH-211188_ref2","doi-asserted-by":"publisher","DOI":"10.3233\/CH-211177"},{"issue":"2","key":"10.3233\/CH-211188_ref3","doi-asserted-by":"publisher","first-page":"75","DOI":"10.4103\/0973-3930.62596","article-title":"Understanding diabetic foot","volume":"30","author":"Pendsey","year":"2010","journal-title":"Int J Diabetes Dev Ctries"},{"issue":"7","key":"10.3233\/CH-211188_ref4","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1002\/dmrr.1004","article-title":"Microvascular dysfunction in diabetic foot disease and ulceration","volume":"25","author":"Chao","year":"2009","journal-title":"Diabetes Metab Res Rev"},{"issue":"2","key":"10.3233\/CH-211188_ref5","first-page":"139","article-title":"Early rheological andmicrocirculatory changes in children with type I diabetes mellitus","volume":"19","author":"Latza","year":"1998","journal-title":"Koscielny J, Clin Hemorheol Microcirc"},{"issue":"Suppl 2","key":"10.3233\/CH-211188_ref6","first-page":"858","article-title":"Plasma protein changes, blood viscosity, and diabetic microangiopathy","volume":"25","author":"McMillan","year":"1976","journal-title":"Diabetes.\u201364. PMID"},{"issue":"Suppl 2","key":"10.3233\/CH-211188_ref7","first-page":"897","article-title":"Red-cell aggregation and red-cell deformability in diabetes","volume":"25","author":"Schmid-Sch\u00f6nbein","year":"1976","journal-title":"Diabetes"},{"issue":"Suppl 2","key":"10.3233\/CH-211188_ref8","doi-asserted-by":"publisher","first-page":"88","DOI":"10.2337\/diab.32.2.s88","article-title":"Red cell deformability, platelet aggregation, and insulin action","volume":"32","author":"Vague","year":"1983","journal-title":"Diabetes"},{"issue":"2","key":"10.3233\/CH-211188_ref9","first-page":"43","article-title":"Impaired hemorheological properties in diabetic patients with lower limb arterial ischaemia","volume":"25","author":"Le Devehat","year":"2001","journal-title":"Clin Hemorheol Microcirc"},{"key":"10.3233\/CH-211188_ref10","unstructured":"Baskurt OK . Mechanism of blood rheology alterations. In: Handbook of Hemorheology and Hemodynamics. Baskurt OK, Hardeman MR, Rampling MW, Meiselman HJ, editors. Amsterdam: IOS Press; 2007. pp. 170\u201390."},{"issue":"6","key":"10.3233\/CH-211188_ref11","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1177\/193229680800200622","article-title":"Hemorheological disorders in diabetes mellitus","volume":"2","author":"Cho","year":"2008","journal-title":"J Diabetes Sci Technol"},{"issue":"1","key":"10.3233\/CH-211188_ref12","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3233\/CH-200873","article-title":"Impaired deformability and association with density distribution of erythrocytes in patients with type 2 diabetes mellitus under treatment","volume":"76","author":"Arita","year":"2020","journal-title":"Clin Hemorheol Microcirc"},{"issue":"4","key":"10.3233\/CH-211188_ref13","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1046\/j.1526-0968.2003.00082","article-title":"Rheopheresis in patients with ischemic diabetic foot syndrome: results of an open label prospective pilot trial","volume":"7","author":"Klingel","year":"2003","journal-title":"Ther Apher Dial"},{"issue":"5","key":"10.3233\/CH-211188_ref14","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1046\/j.1526-0968.2000.004005348.x","article-title":"Rheopheresis: rheologic, functional, and structural aspects","volume":"4","author":"Klingel","year":"2000","journal-title":"Ther Apher"},{"issue":"10","key":"10.3233\/CH-211188_ref15","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1177\/039139880703001010","article-title":"Rheopheresis in vascular diseases","volume":"30","author":"Ferrannini","year":"2007","journal-title":"Int J Artif Organs"},{"issue":"3","key":"10.3233\/CH-211188_ref16","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1002\/jca.21705","article-title":"Guidelines on the Use of Therapeutic Apheresis in Clinical Practice - Evidence-Based Approach from the Writing Committee of the American Society for Apheresis: The Eighth Special Issue","volume":"34","author":"Padmanabhan","year":"2019","journal-title":"J Clin Apher"},{"issue":"4","key":"10.3233\/CH-211188_ref17","doi-asserted-by":"publisher","first-page":"977","DOI":"10.3233\/CH-168004","article-title":"Rheopheresis in vascular diseases","volume":"64","author":"Vass","year":"2016","journal-title":"Clin Hemorheol Microcirc"},{"issue":"1","key":"10.3233\/CH-211188_ref18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1469-1809.2009.00551.x","article-title":"Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study","volume":"74","author":"Carty","year":"2010","journal-title":"Ann Hum Genet"},{"key":"10.3233\/CH-211188_ref19","doi-asserted-by":"publisher","first-page":"7104352","DOI":"10.1155\/2018\/7104352","article-title":"The role of serumprocalcitonin, interleukin-6, and fibrinogen levels in differentialdiagnosis of diabetic foot ulcer infection","volume":"2018","author":"Korkmaz","year":"2018","journal-title":"J Diabetes Res"},{"key":"10.3233\/CH-211188_ref20","doi-asserted-by":"publisher","first-page":"754802","DOI":"10.1155\/2013\/754802","article-title":"Abnormal cell responses and role of TNF-\u03b1 in impaired diabetic wound healing","volume":"2013","author":"Xu","year":"2013","journal-title":"Biomed Res Int"},{"key":"10.3233\/CH-211188_ref21","doi-asserted-by":"publisher","first-page":"169","DOI":"10.2147\/JPR.S21751","article-title":"High TNF-alpha plasma levels and macrophages iNOS and TNF-alpha expression as risk factors for painful diabetic neuropathy","volume":"4","author":"Purwata","year":"2011","journal-title":"J Pain Res"},{"issue":"2","key":"10.3233\/CH-211188_ref22","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1007\/s12035-016-9702-z","article-title":"Association between tumor necrosis factor-\u03b1 and diabetic peripheral neuropathy in patients with type 2 diabetes: a meta-analysis","volume":"54","author":"Mu","year":"2017","journal-title":"Mol Neurobiol"},{"key":"10.3233\/CH-211188_ref23","doi-asserted-by":"publisher","first-page":"9051929","DOI":"10.1155\/2019\/9051929","article-title":"Association of Tumor Necrosis Factor Alpha, Interleukin 6, and C-Reactive Protein with the Risk of Developing Type 2 Diabetes: A Retrospective Cohort Study of Rural Thais","volume":"2019","author":"Lainampetch","journal-title":"J Diabetes Res"},{"issue":"10","key":"10.3233\/CH-211188_ref24","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1007\/s00592-017-1039-1","article-title":"Circulating IL-8 levels are increased in patients with type 2 diabetes and associated with worse inflammatory and cardiometabolic profile","volume":"54","author":"Cimini","year":"2017","journal-title":"Acta Diabetol"},{"key":"10.3233\/CH-211188_ref25","unstructured":"Hardeman MR , Goedhart PT , Shin S . Methods in hemorheology. In: Handbook of Hemorheology and Hemodynamics. Baskurt OK, Hardeman MR, Rampling MW, Meiselman HJ, editors. Amsterdam: IOS Press; 2007. pp. 242\u2013266."},{"issue":"2","key":"10.3233\/CH-211188_ref26","doi-asserted-by":"publisher","first-page":"155","DOI":"10.3233\/BIR-2009-0533","article-title":"Inter-species differences in hematocrit to blood viscosity ratio","volume":"46","author":"Nemeth","year":"2009","journal-title":"Biorheology"},{"issue":"10027","key":"10.3233\/CH-211188_ref27","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1016\/S0140-6736(16)00618-8","article-title":"Worldwide trends in diabetes since a pooled analysis of 751 population-based studies with 4.4 million participants","volume":"387","author":"NCD Risk Factor Collaboration (NCD-RisC)","year":"2016","journal-title":"Lancet"},{"issue":"5","key":"10.3233\/CH-211188_ref28","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1089\/wound.2013.0518","article-title":"The Diabetic Foot: A Historical Overview and Gaps in Current Treatment","volume":"5","author":"Naves","year":"2016","journal-title":"Adv Wound Care (New Rochelle)"},{"issue":"32","key":"10.3233\/CH-211188_ref29","doi-asserted-by":"publisher","first-page":"5695","DOI":"10.2174\/1381612811319320005","article-title":"Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases","volume":"19","author":"Fiorentino","year":"2004","journal-title":"Curr Pharm Des"},{"issue":"4","key":"10.3233\/CH-211188_ref30","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s00418-004-0678-9","article-title":"Hyperglycemia-induced oxidative stress in diabetic complications","volume":"122","author":"King","year":"2004","journal-title":"Histochem Cell Biol"},{"issue":"18","key":"10.3233\/CH-211188_ref31","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.2174\/1381612054367328","article-title":"Microcirculation of the diabetic foot","volume":"11","author":"Dinh","year":"2005","journal-title":"Curr Pharm Des"},{"issue":"6","key":"10.3233\/CH-211188_ref32","doi-asserted-by":"publisher","first-page":"525","DOI":"10.2217\/dmt.15.44","article-title":"The cytokine milieu of diabetic wounds","volume":"5","author":"DeClue","year":"2015","journal-title":"Diabetes Manag"},{"key":"10.3233\/CH-211188_ref33","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.aca.2014.10.009","article-title":"Bioanalytical chemistry of cytokines - a review","volume":"853","author":"Stenken","year":"2015","journal-title":"Anal Chim Acta"},{"issue":"1","key":"10.3233\/CH-211188_ref34","first-page":"3","article-title":"Cytokine binding and clearance properties of proteinase-activated alpha 2-macroglobulins","volume":"65","author":"LaMarre","year":"1991","journal-title":"Lab Invest"},{"issue":"1","key":"10.3233\/CH-211188_ref35","doi-asserted-by":"crossref","first-page":"148","DOI":"10.4049\/jimmunol.142.1.148","article-title":"Identification of alpha 2-macroglobulin as a carrier protein for IL-6","volume":"142","author":"Matsuda","year":"1989","journal-title":"J Immunol"}],"container-title":["Clinical Hemorheology and Microcirculation"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/CH-211188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:05:44Z","timestamp":1777388744000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/CH-211188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,17]]},"references-count":35,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/ch-211188","relation":{},"ISSN":["1386-0291","1875-8622"],"issn-type":[{"value":"1386-0291","type":"print"},{"value":"1875-8622","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,17]]}}}