{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:13:18Z","timestamp":1777497198940,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CH"],"published-print":{"date-parts":[[2022,4,6]]},"abstract":"<jats:p>OBJECTIVE: To investigate the association between ultrasound appearances and pathological features in small breast cancer. MATERIALS AND METHODS: A total of 186 small breast cancers in 186 patients were analyzed in this retrospective study from January 2015 to December 2019 according to pathological results. Forty-seven cases of axillary lymph node metastasis were found. All patients underwent radical axillary surgery following conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS) examinations. The association between ultrasound appearances and pathological features was analyzed using univariate distributions and multivariate analysis. Then, a logistic regression model was established using the pathological diagnosis of lymph node metastasis and biochemical indicators as the dependent variable and the ultrasound appearances as independent variables. RESULTS: In small breast cancer, risk factors of axillary lymph node metastasis were crab claw-like enhancement on CEUS and abnormal axillary lymph nodes on US. The logistic regression model was established as follows: (axillary lymph node metastasis)\u200a=\u200a1.100\u00d7(crab claw-like enhancement of CEUS) + 2.749\u00d7(abnormal axillary lymph nodes of US) \u20135.790. In addition, irregular shape on CEUS and posterior echo attenuation on US were risk factors for both positive estrogen receptor and progesterone receptor expression, whereas calcification on US was a risk factor for positive Her-2 expression. A\u00a0specific relationship could be found using the following logistic models: (positive ER expression)\u200a=\u200a1.367\u00d7(irregular shape of CEUS) + 1.441\u00d7(posterior echo attenuation of US) \u20135.668; (positive PR expression)\u200a=\u200a1.265\u00d7(irregular shape of CEUS) + 1.136\u00d7(posterior echo attenuation of US) \u20134.320; (positive Her-2 expression)\u200a=\u200a1.658\u00d7(calcification of US) \u20130.896. CONCLUSION: Logistic models were established to provide significant value for the prediction of pre-operative lymph node metastasis and positive biochemical indicators, which may guide clinical treatment.<\/jats:p>","DOI":"10.3233\/ch-211291","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T11:32:26Z","timestamp":1637926346000},"page":"413-422","source":"Crossref","is-referenced-by-count":11,"title":["The association between conventional ultrasound and contrast-enhanced ultrasound appearances and pathological features in small breast cancer"],"prefix":"10.1177","volume":"80","author":[{"given":"Jing","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-xiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Shanghai 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