{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:13:45Z","timestamp":1777497225690,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CH"],"published-print":{"date-parts":[[2022,4,23]]},"abstract":"<jats:p>OBJECTIVE: To examine whether contrast-enhanced ultrasound (CEUS) parameters in patients with advanced pancreatic cancer could be used to assess response to treatment with pulsed-wave high intensity focused ultrasound (PW-HIFU). METHODS: We prospectively recorded the pretreatment and posttreatment CEUS related parameters, CA19-9, pain scores of 30 patients with advanced pancreatic cancer treated with PW-HIFU treatment. Correlation of clinical parameters, tumor characteristics, and PW-HIFU treatment energy with CEUS parameters were analyzed. RESULTS: Pain score decreased after treatment (from 4.80\u00b12.14 to 3.28\u00b11.93, p\u200a=\u200a0.001). CA19-9 dropped in RT decreased group, 4 weeks after one session PW-HIFU, compared with prolonged group (p\u200a=\u200a0.013). According to the display of blood vessels in the mass by CEUS, tumors were classified by vessel grade (VG), VG1: no vessel can be seen; VG 2: vessels diameter &lt;\u200a5\u200amm; VG 3: vessels diameter &gt;\u200a5\u200amm. VGs were different between increased and decreased relative rise intensity (rRI) groups (p\u200a=\u200a0.008). VG1 group shown a decreased rRI after treatment, while VG3 group showed the opposite trend (p\u200a=\u200a0.006). CONCLUSIONS: CEUS can evaluating response to PW-HIFU in advanced pancreatic cancer. Quantitative analysis may help to assess the short-term efficacy of patients and help for individualized treatment.<\/jats:p>","DOI":"10.3233\/ch-211342","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T11:41:40Z","timestamp":1641555700000},"page":"57-67","source":"Crossref","is-referenced-by-count":7,"title":["Contrast-enhanced ultrasound for evaluating response to pulsed-wave high-intensity focused ultrasound therapy in advanced pancreatic cancer"],"prefix":"10.1177","volume":"81","author":[{"given":"Yu","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian-quan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-na","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin-xue","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/CH-211342_ref1","doi-asserted-by":"crossref","unstructured":"Mizrahi JD , Surana R , Valle JW , Shroff RT . 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