{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:14:12Z","timestamp":1777497252774,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CH"],"published-print":{"date-parts":[[2022,7,26]]},"abstract":"<jats:p>BACKGROUND: Psoriasis is associated with an increased risk for cardiovascular disease (CVD). Methotrexate (MTX) is often used as a first-line system therapy and there is a need to determine its effect on whole blood viscosity (WBV) and plasma viscosity (PV) in psoriasis. METHODS A prospective, single-center, interventional study with a total of 111 psoriatic patients who received MTX therapy from October 22, 2018, to December 28, 2019, and 111 age- and sex-matched healthy controls. Changes in WBV, PV, blood counts, liver and renal function were evaluated. RESULTS Psoriatic patients had significantly higher levels of WBV and relative viscosity (RV) at low shear rate (LSR), erythrocyte aggregation index (EAI), and PV than sex and age-matched healthy controls. PV was positively correlated with erythrocyte sedimentation rate (ESR), ESR was positively correlated with high sensitive C-reactive protein (hCRP). But only hCRP was positively associated with psoriasis area severity index (PASI) score. MTX significantly decreased the levels of PV, ESR, hCRP, and blood pressure (BP) in male patients, and the level of WBV in female patients. CONCLUSION: Sex-specific downregulation of MTX on WBV, PV, hCRP, and BP, indicating that the effect of MTX on the risk of cardiovascular disease was related with sex.<\/jats:p>","DOI":"10.3233\/ch-211343","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T12:04:15Z","timestamp":1650369855000},"page":"305-314","source":"Crossref","is-referenced-by-count":1,"title":["Sex-differential downregulation of methotrexate on plasma viscosity and whole blood viscosity in psoriasis"],"prefix":"10.1177","volume":"81","author":[{"given":"Ling","family":"Han","sequence":"first","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiliang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shanghai Jiaotong University Affiliated Sixth People\u2019s Hospital, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinqin","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shanghai Jiaotong University Affiliated Sixth People\u2019s Hospital, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenghua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Fang","sequence":"additional","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Information, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhizhong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhil","family":"Yawalkar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shanghai Jiaotong University Affiliated Sixth People\u2019s Hospital, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kexiang","family":"Yan","sequence":"additional","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/CH-211343_ref1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jaad.2008.09.022","article-title":"The prevalence of previously diagnosed and undiagnosed psoriasis in US adults: results from NHANES 2003-2004","volume":"60","author":"Kurd","year":"2009","journal-title":"Journal of the American Academy of Dermatology"},{"key":"10.3233\/CH-211343_ref2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jaad.2016.07.064","article-title":"Psoriasis and comorbid diseases: Epidemiology","volume":"76","author":"Takeshita","year":"2017","journal-title":"Journal of the American Academy of Dermatology"},{"key":"10.3233\/CH-211343_ref3","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/rheumatology\/kep366","article-title":"The effect of methotrexate on cardiovascular disease in patients with rheumatoid arthritis: a systematic literature review","volume":"49","author":"Westlake","year":"2010","journal-title":"Rheumatology"},{"key":"10.3233\/CH-211343_ref4","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.amjcard.2011.06.054","article-title":"Systematic review and meta-analysis of methotrexate use and risk of cardiovascular disease","volume":"108","author":"Micha","year":"2011","journal-title":"The American Journal of Cardiology"},{"key":"10.3233\/CH-211343_ref5","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease","volume":"377","author":"Ridker","year":"2017","journal-title":"The New England Journal of Medicine"},{"key":"10.3233\/CH-211343_ref7","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1056\/NEJM200003233421202","article-title":"C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women","volume":"342","author":"Ridker","year":"2000","journal-title":"The New England Journal of Medicine"},{"key":"10.3233\/CH-211343_ref8","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.ehj.2004.04.011","article-title":"Haemostatic\/inflammatory markers predict 10-year risk of IHD at least as well as lipids: the Caerphilly collaborative studies","volume":"25","author":"Yarnell","year":"2004","journal-title":"European Heart Journal"},{"key":"10.3233\/CH-211343_ref9","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1055\/s-0037-1614066","article-title":"Blood rheology, cardiovascular risk factors, and cardiovascular disease: the West of Scotland Coronary Prevention Study","volume":"84","author":"Lowe","year":"2000","journal-title":"Thrombosis and Haemostasis"},{"key":"10.3233\/CH-211343_ref10","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/ajh\/4.6.529","article-title":"Association between plasma viscosity and blood pressure. Results from the MONICA-project Augsburg","volume":"4","author":"Koenig","year":"1991","journal-title":"American Journal of Hypertension"},{"key":"10.3233\/CH-211343_ref11","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3233\/CH-2010-1312","article-title":"From hemorheology to microcirculation and regenerative medicine: Fahraeus Lecture 2009","volume":"45","author":"Jung","year":"2010","journal-title":"Clinical Hemorheology and Microcirculation"},{"key":"10.3233\/CH-211343_ref12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3233\/CH-2011-1392","article-title":"Influence of rheological parameters on the velocity of erythrocytes passing nailfold capillaries in humans","volume":"48","author":"Jung","year":"2011","journal-title":"Clinical Hemorheology and Microcirculation"},{"key":"10.3233\/CH-211343_ref13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1177\/2047487316672004","article-title":"Plasma and blood viscosity in the prediction of cardiovascular disease and mortality in the Scottish Heart Health Extended Cohort Study","volume":"24","author":"Peters","year":"2017","journal-title":"European Journal of Preventive Cardiology"},{"key":"10.3233\/CH-211343_ref14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3109\/08037059709061932","article-title":"Whole blood viscosity, blood pressure and cardiovascular risk factors in healthy blood donors","volume":"6","author":"Fossum","year":"1997","journal-title":"Blood Pressure"},{"key":"10.3233\/CH-211343_ref15","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3233\/CH-2012-1639","article-title":"Psoriasis and hemorheology","volume":"55","author":"Vaya","year":"2013","journal-title":"Influence of the metabolic syndrome. Clinical Hemorheology and Microcirculation"},{"key":"10.3233\/CH-211343_ref16","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2340\/0001555561153154","article-title":"Blood hyperviscosity in psoriasis","volume":"61","author":"Wolf","year":"1981","journal-title":"Acta Dermato-Venereologica"},{"key":"10.3233\/CH-211343_ref17","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3233\/BIR-1994-31207","article-title":"Influence of hematocrit on erythrocyte aggregation kinetics for suspensions of red blood cells in autologous plasma","volume":"31","author":"Deng","year":"1994","journal-title":"Biorheology"},{"key":"10.3233\/CH-211343_ref18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1515\/bmte.1987.32.5.117","article-title":"[Simultaneous recording of hematocrit, erythrocyte aggregation and disaggregation: methodology, quality control and reference ranges]","volume":"32","author":"Jung","year":"1987","journal-title":"Biomedizinische Technik. Biomedical Engineering"},{"key":"10.3233\/CH-211343_ref19","doi-asserted-by":"crossref","first-page":"H1982","DOI":"10.1152\/ajpheart.2001.280.5.H1982","article-title":"Parameters of red blood cell aggregation as correlates of the inflammatory state","volume":"280","author":"Ami","year":"2001","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"10.3233\/CH-211343_ref20","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/ibd.20838","article-title":"Increased strength of erythrocyte aggregates in blood of patients with inflammatory bowel disease","volume":"15","author":"Maharshak","year":"2009","journal-title":"Inflammatory Bowel Diseases"},{"key":"10.3233\/CH-211343_ref21","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1161\/01.CIR.51.6.1079","article-title":"Observations on blood viscosity changes after acute myocardial infarction","volume":"51","author":"Jan","year":"1975","journal-title":"Circulation"},{"key":"10.3233\/CH-211343_ref22","doi-asserted-by":"crossref","first-page":"7173","DOI":"10.1038\/s41598-018-25317-8","article-title":"Significantly increased low shear rate viscosity, blood elastic modulus, and RBC aggregation in adults following cardiac surgery","volume":"8","author":"Wu","year":"2018","journal-title":"Scientific Reports"},{"key":"10.3233\/CH-211343_ref23","first-page":"2","article-title":"Protective effects of methotrexate against ischemic cardiovascular disorders in patients treated for rheumatoid arthritis or psoriasis: novel therapeutic insights coming from a meta-analysis of the literature data","volume":"16","author":"De Vecchis","year":"2016","journal-title":"Anatolian Journal of Cardiology"},{"key":"10.3233\/CH-211343_ref24","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3233\/CH-2008-1088","article-title":"Plasma viscosity: a forgotten variable","volume":"39","author":"Kesmarky","year":"2008","journal-title":"Clinical Hemorheology and Microcirculation"},{"key":"10.3233\/CH-211343_ref25","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/1346-8138.13213","article-title":"Serum C-reactive protein levels in Japanese patients with psoriasis and psoriatic arthritis: Long-term differential effects of biologics","volume":"43","author":"Asahina","year":"2016","journal-title":"The Journal of Dermatology"},{"key":"10.3233\/CH-211343_ref26","doi-asserted-by":"crossref","first-page":"322","DOI":"10.4103\/2229-5178.164483","article-title":"Role of C-reactive protein as a marker of disease severity and cardiovascular risk in patients with psoriasis","volume":"6","author":"Vadakayil","year":"2015","journal-title":"Indian Dermatology Online Journal"},{"key":"10.3233\/CH-211343_ref27","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1046\/j.1365-2141.1997.8532481.x","article-title":"Blood viscosity and risk of cardiovascular events: the Edinburgh Artery Study","volume":"96","author":"Lowe","year":"1997","journal-title":"British Journal of Haematology"},{"key":"10.3233\/CH-211343_ref29","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jaad.2004.06.017","article-title":"Methotrexate reduces incidence of vascular diseases in veterans with psoriasis or rheumatoid arthritis","volume":"52","author":"Prodanovich","year":"2005","journal-title":"Journal of the American Academy of Dermatology"},{"key":"10.3233\/CH-211343_ref30","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/1759720X17719850","article-title":"Methotrexate, blood pressure and markers of arterial function in patients with rheumatoid arthritis: a repeated cross-sectional study","volume":"9","author":"Mangoni","year":"2017","journal-title":"Therapeutic Advances in Musculoskeletal Disease"},{"key":"10.3233\/CH-211343_ref31","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3389\/fphys.2017.00593","article-title":"The Temporal Relationship between Arterial Stiffening and Blood Pressure Is Modified by Methotrexate Treatment in Patients with Rheumatoid Arthritis","volume":"8","author":"Woodman","year":"2017","journal-title":"Frontiers in Physiology"},{"key":"10.3233\/CH-211343_ref32","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3233\/CH-190799","article-title":"The effect of hematocrit, fibrinogen concentration and temperature on the kinetics of clot formation of whole blood","volume":"75","author":"Windberger","year":"2020","journal-title":"Clinical Hemorheology and Microcirculation"}],"container-title":["Clinical Hemorheology and Microcirculation"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/CH-211343","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:05:56Z","timestamp":1777388756000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medra.org\/servlet\/aliasResolver?alias=iospress&doi=10.3233\/CH-211343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,26]]},"references-count":30,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3233\/ch-211343","relation":{},"ISSN":["1386-0291","1875-8622"],"issn-type":[{"value":"1386-0291","type":"print"},{"value":"1875-8622","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,26]]}}}