{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:18:07Z","timestamp":1777497487188,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CH"],"published-print":{"date-parts":[[2023,12,12]]},"abstract":"<jats:p>OBJECTIVE: To evaluate the contrast enhanced ultrasound (CEUS) and contrast enhanced magnetic resonance imaging (CEMRI) features of intrahepatic splenosis (IHS). METHODS &amp; MATERIALS: Five patients (three males and two females, median age, 44 years; range,32\u201373 years) with seven IHSs were retrieved from the database of our hospital from March 2012 to October 2021. All IHSs were confirmed histologically by surgery. The CEUS and CEMRI characteristics of individual lesion were fully analyzed. RESULTS: All IHS patients were asymptomatic and four out of five patients had history of splenectomy. On CEUS, all IHSs were hyperenhancement in arterial phase. 71.4% (5\/7) of IHSs manifested overall filling within few seconds, the other two lesions showed centripetal filling. Subcapsular vascular hyperenhancement and feeding artery was seen in 28.6% (2\/7) and 42.9% (3\/7) of IHSs, respectively. During portal venous phase, IHSs presented hyperenhancement (2\/7) or isoenhancement (5\/7). Moreover, rim-like hypoenhanced area was uniquely observed surrounding 85.7% (6\/7) of IHSs. In late phase, seven IHSs remained continuous hyper- or isoenhancement. On CEMRI, five IHSs showed mosaic hyperintense in early arterial phase, the other two lesions showed homogeneous hyperintense. In portal venous phase, all IHSs revealed continuous hyper- (71.4%, 5\/7) or iso-intense (28.6%, 2\/7). During late phase, one IHS (14.3%, 1\/7) became hypointense, the other lesions remained hyper- or isointense. CONCLUSION: Diagnosis of IHS can be based on typical CEUS and CEMRI features in patients with history of splenectomy.<\/jats:p>","DOI":"10.3233\/ch-221582","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T11:29:35Z","timestamp":1676978975000},"page":"211-221","source":"Crossref","is-referenced-by-count":5,"title":["Intrahepatic splenosis: Contrast enhanced ultrasound and magnetic resonance imaging findings"],"prefix":"10.1177","volume":"85","author":[{"given":"Kailing","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peili","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongkui","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"2","key":"10.3233\/CH-221582_ref1","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1007\/BF00198054","article-title":"Intrahepatic splenosis mimicking a liver tumor[J]","volume":"18","author":"Yoshimitsu","year":"1993","journal-title":"Abdom Imaging"},{"issue":"3","key":"10.3233\/CH-221582_ref2","doi-asserted-by":"publisher","first-page":"185","DOI":"10.5114\/ceh.2020.99509","article-title":"Intrahepatic splenosis: a world review[J]","volume":"6","author":"Toh","year":"2020","journal-title":"Clin Exp Hepatol"},{"issue":"3","key":"10.3233\/CH-221582_ref3","doi-asserted-by":"publisher","first-page":"e24243","DOI":"10.1097\/MD.0000000000024243","article-title":"Contrast-enhanced ultrasonographic imaging of hepatic splenosis: A case report[J]","volume":"100","author":"Zhong","year":"2021","journal-title":"Medicine (Baltimore)."},{"issue":"5","key":"10.3233\/CH-221582_ref4","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.radcr.2020.02.022","article-title":"Intrahepatic splenosis demonstrated by diffusion weighted MRI with histologic confirmation[J]","volume":"15","author":"Gandhi","year":"2020","journal-title":"Radiol Case Rep"},{"issue":"2","key":"10.3233\/CH-221582_ref5","doi-asserted-by":"publisher","first-page":"257","DOI":"10.15403\/jgld-617","article-title":"An Uncommon Focal Liver Lesion: Intrahepatic Splenosis[J]","volume":"29","author":"Sansone","year":"2020","journal-title":"J Gastrointestin Liver Dis"},{"issue":"7","key":"10.3233\/CH-221582_ref6","doi-asserted-by":"publisher","first-page":"2274","DOI":"10.1007\/s00261-020-02451-4","article-title":"A case of intrahepatic splenosis: usefulness of splenic scintigraphy[J]","volume":"45","author":"Kawada","year":"2020","journal-title":"Abdom Radiol (NY)"},{"issue":"3","key":"10.3233\/CH-221582_ref7","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.mayocpiqo.2019.04.005","article-title":"A Practical Guideline for Hepatocellular Carcinoma Screening in Patients at Risk[J]","volume":"3","author":"Frenette","year":"2019","journal-title":"Mayo Clin Proc Innov Qual Outcomes"},{"issue":"4","key":"10.3233\/CH-221582_ref8","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1177\/0300060519828901","article-title":"Hepatic splenosis: Rare yet important - 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