{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T02:39:13Z","timestamp":1788057553324,"version":"build-2784847793"},"reference-count":30,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T00:00:00Z","timestamp":1676678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2023,5,17]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>BACKGROUND\/OBJECTIVE:<\/jats:title>\n                    <jats:p>Oral malformations of the tongue are exceedingly rare. The aim of this study was to evaluate the effectiveness of individualized treatment for patients with vascular malformations of the tongue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>This retrospective study is based on a consecutive local registry at a tertiary care Interdisciplinary Center for Vascular Anomalies. Patients with vascular malformations of the tongue were included. Indications for therapy of the vascular malformation were macroglossia with the impossibility to close the mouth, bleeding, recurrent infection and dysphagia. Size regression of the malformation (volume measurement) and symptom improvement were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Out of 971 consecutive patients with vascular malformations, 16 patients suffered from a vascular malformation of the tongue. Twelve patients had slow-flow malformations and 4 fast-flow malformations. Indications for interventions were bleeding (4\/16, 25%), macroglossia (6\/16, 37.5%), and recurrent infections (4\/16, 25%). For two patients (2\/16, 12.5%), there was no indication for intervention due to absence of symptoms. Four patients received sclerotherapy, 7 patients Bleomycin-electrosclerotherapy (BEST) and 3 patients embolization. Median follow-up was 16 months (IQR 7\u201335.5). In all patients, symptoms had decreased after two interventions at a median (IQR 1\u20133.75). Volume reduction of the malformation of the tongue was 13.3% (from median 27.9\u200acm\n                      <jats:sup>3<\/jats:sup>\n                      to median 24.2\u200acm\n                      <jats:sup>3<\/jats:sup>\n                      ,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.0039), and even more pronounced when considering only patients with BEST (from 86\u200acm\n                      <jats:sup>3<\/jats:sup>\n                      to 59.1\u200acm\n                      <jats:sup>3<\/jats:sup>\n                      ,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>Symptoms of vascular malformations of the tongue are improved after a median of two interventions with significantly increased volume reduction after Bleomycin-electrosclerotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/ch-221683","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T11:29:48Z","timestamp":1676978988000},"page":"421-429","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Individualized treatment of congenital vascular malformations of the tongue"],"prefix":"10.1177","volume":"83","author":[{"given":"Moritz","family":"Guntau","sequence":"first","affiliation":[{"name":"University Hospital Halle (Saale)","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrix","family":"Cucuruz","sequence":"additional","affiliation":[{"name":"University Hospital Regensburg","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Brill","sequence":"additional","affiliation":[{"name":"University Hospital Halle (Saale)","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksandr","family":"Bidakov","sequence":"additional","affiliation":[{"name":"University Hospital Halle (Saale)","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Von der Heydt","sequence":"additional","affiliation":[{"name":"University Hospital Halle (Saale)","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Deistung","sequence":"additional","affiliation":[{"name":"University Hospital Halle (Saale)","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter A.","family":"Wohlgemuth","sequence":"additional","affiliation":[{"name":"University Hospital Halle (Saale)","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,2,18]]},"reference":[{"key":"e_1_3_1_2_2","unstructured":"BoonLM VikkulaM. Chapter 172. Vascular Malformations. In: Goldsmith LA Katz SI Gilchrest BA Paller AS Leffell DJ Wolff K editors. Fitzpatrick\u2019s Dermatology in General Medicine 8e. New York NY: The McGraw-Hill Companies; 2012. pp. 2076\u201394."},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X20918941"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.23736\/S0392-9590.18.03961-5"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2004.07.023"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-011-0123-0"},{"issue":"3","key":"e_1_3_1_7_2","first-page":"353","article-title":"Vascular malformations: Part I","volume":"56","author":"Garzon MC","year":"2007","unstructured":"GarzonMC, HuangJT, EnjolrasO, FriedenIJ Vascular malformations: Part I. 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