{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:09:06Z","timestamp":1780445346148,"version":"3.54.1"},"reference-count":53,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CH"],"published-print":{"date-parts":[[2024,6,13]]},"abstract":"<jats:p>BACKGROUND: Post-occlusive reactive hyperemia (PORH) typically requires caffeine abstinence. For habitual users, it is unknown if abstinence affects PORH. OBJECTIVE: Compare PORH after habitual users consume or abstain from caffeine. METHODS: On separate visits (within-subject), PORH was measured in 30 participants without abstinence from typical caffeine doses (CAFF) and with abstinence (ABS). Measurements included baseline and peak hyperemic velocity, tissue saturation index slopes during ischemia (Slope 1) and following cuff deflation (Slope 2), resting arterial occlusion pressure (AOP), heart rate (HR), systolic (SBP), and diastolic (DBP) blood pressure. All variables were compared using Bayesian paired t-tests. BF10\u200a=\u200alikelihood of alternative vs null. Results are mean\u00b1SD. RESULTS: Comparing baseline velocity (cm\/s) between CAFF (9.3\u00b14.8) and ABS (7.5\u00b14.9) yielded anecdotal evidence (BF10\u200a=\u200a1.0). Peak hyperemic velocity (cm\/s) was similar (CAFF\u200a=\u200a77.3\u00b116.7; ABS\u200a=\u200a77.6\u00b119.0, BF10\u200a=\u200a0.20). For slopes (TSI% \/s), CAFF Slope 1\u200a=\u200a\u20130.11\u00b10.04 and Slope 2\u200a=\u200a1.9\u00b10.46 were similar (both BF10\u22640.20) to ABS Slope 1\u200a=\u200a\u20130.12\u00b10.03 and Slope 2\u200a=\u200a1.8\u00b10.42. SBP and DBP (mmHg) were both similar (CAFF SBP\u200a=\u200a116.0\u00b19.8, DBP\u200a=\u200a69.6\u00b15.8; ABS SBP\u200a=\u200a115.5\u00b110.7, DBP\u200a=\u200a69.5\u00b15.4; both BF10\u22640.22). Comparing AOP (mmHg) (CAFF\u200a=\u200a146.6\u00b115.0; ABS\u200a=\u200a143.0\u00b116.4) yielded anecdotal evidence (BF10\u200a=\u200a0.46). HR (bpm) was similar (CAFF\u200a=\u200a66.5\u00b112.3; ABS\u200a=\u200a66.9\u00b113.0; BF10\u200a=\u200a0.20). CONCLUSIONS: In habitual users, consuming or abstaining from typical caffeine doses does not appear to affect post-occlusive reactive hyperemia.<\/jats:p>","DOI":"10.3233\/ch-232036","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T11:04:48Z","timestamp":1705403088000},"page":"101-113","source":"Crossref","is-referenced-by-count":4,"title":["Post-occlusive reactive hyperemia in habituated caffeine users: Effects of abstaining versus consuming typical doses"],"prefix":"10.1177","volume":"87","author":[{"given":"Matthew A.","family":"Chatlaong","sequence":"first","affiliation":[{"name":"Department of Health, Exercise Science, and Recreation Management, Applied Human Health and Physical Function Laboratory, University of Mississippi, Oxford, MS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphney M.","family":"Stanford","sequence":"additional","affiliation":[{"name":"Department of Exercise Science and Sport Management, Kennesaw State University, Kennesaw, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Miller","sequence":"additional","affiliation":[{"name":"University of Evansville, School of Health Sciences, Evansville, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chance J.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Department of Health, Exercise Science, and Recreation Management, Applied Human Health and Physical Function Laboratory, University of Mississippi, Oxford, MS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew B.","family":"Jessee","sequence":"additional","affiliation":[{"name":"Department of Health, Exercise Science, and Recreation Management, Applied Human Health and Physical Function Laboratory, University of Mississippi, Oxford, MS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"issue":"3","key":"10.3233\/CH-232036_ref1","doi-asserted-by":"crossref","first-page":"R605","DOI":"10.1152\/ajpregu.00339.2019","article-title":"Reactive hyperemia: a review of methods, mechanisms, and considerations American Journal of Physiology-Regulatory","volume":"318","author":"Rosenberry","year":"2020","journal-title":"Integrative and Comparative Physiology."},{"issue":"5","key":"10.3233\/CH-232036_ref2","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1148\/90.5.975","article-title":"Reactive hyperemia in lower extremity arteriography: an evaluation","volume":"90","author":"Kahn","year":"1968","journal-title":"Radiology"},{"key":"10.3233\/CH-232036_ref3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mvr.2013.10.004","article-title":"Relationship between brachial artery blood flow and total [hemoglobin+myoglobin] during post-occlusive reactive hyperemia","volume":"91","author":"Bopp","year":"2014","journal-title":"Microvascular research"},{"issue":"1","key":"10.3233\/CH-232036_ref4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1113\/jphysiol.1976.sp011358","article-title":"Endogenous prostaglandins as local regulators of blood flow in man: effect of indomethacin on reactive and functional hyperaemia","volume":"257","author":"Kilbom","year":"1976","journal-title":"The Journal of Physiology"},{"issue":"18","key":"10.3233\/CH-232036_ref5","doi-asserted-by":"crossref","first-page":"e017018","DOI":"10.1161\/JAHA.120.017018","article-title":"Clinical Associations of Vascular Stiffness, Microvascular Dysfunction, and Prevalent Cardiovascular Disease in a Black Cohort: The Jackson Heart Study","volume":"9","author":"Cooper","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"10.3233\/CH-232036_ref6","doi-asserted-by":"crossref","unstructured":"Cooper LL , Palmisano JN , Benjamin EJ , Larson MG , Vasan RS , Mitchell GF , et al Microvascular Function Contributes to the Relation Between Aortic Stiffness and Cardiovascular Events: The Framingham Heart Study. 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