{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:17:56Z","timestamp":1777497476254,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"1-2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CH"],"published-print":{"date-parts":[[2024,2,22]]},"abstract":"<jats:p>OBJECTIVE: Multiparametric magnetic resonance imaging (mpMRI) \u2013Ultrasound- fusion guided biopsy of the prostate (FBx) is the new gold standard for the detection of prostate cancer. Hallmark studies showing superior detection rates of FBx over randomized biopsies routinely excluded patients\u226575 years and information on outcome of FBx on this patient cohort is sparse. As a large referral center, we have performed FBx on a substantial number of patients this age. By evaluating outcome of FBx of patients over the age of 75 years we wanted to close the gap of knowledge on this patient cohort. MATERIALS AND METHODS: Between 2015 \u20132022, 1577 patients underwent FBx at our department and were considered for analysis. Clinical and histopathological parameters were recorded. Clinical data comprised age at FBx, serum level of Prostate-specific antigen (PSA), prostate volume, PSA-density, history of previous biopsies of the prostate, result of the digital rectal examination (DRE) and assessment of the indexlesion of mpMRI according to the Prostate Imaging and Reporting Data System (PI-RADS). Univariate analysis and multivariable logistic regression was used to identify age barrier of 75 years as a potential risk factor of detection of clinically significant prostate cancer by FBx. RESULTS: 379\/1577 patients (24%) were\u226575 years and 1198\/1577 (76%) patients were\u200a&lt;\u200a75 years, respectively. Preoperative PSA was significantly higher in patients\u226575 years compared to patients\u200a&lt;\u200a75 years (9.54 vs. 7.8, p\u200a&lt;\u200a0.001). Patients\u226575 years presented significantly more often with mpMRI target lesions classified as PI-RADS 5 compared to patients\u200a&lt;\u200a75 years (45% vs. 29%, p\u200a&lt;\u200a0.001). Detection rate of clinically significant prostate cancer was significantly higher in patients\u226575 years compared to patients\u200a&lt;\u200a75 years (63% vs. 43%, p\u200a&lt;\u200a0.001). Aggressive prostate cancer grade ISUP 5 was significantly more often detected in patients\u226575 years compared to patients\u200a&lt;\u200a75 years (13% vs. 8%, p\u200a=\u200a0.03). On multivariable logistic regression model adjusted for PSA and PI-RADS score, age barrier of 75 years was identified as a significant risk factor for the detection of clinically significant prostate cancer by FBx (OR: 1.77, 95% CI: 1.36 \u20132.31, p\u200a&lt;\u200a0.001). CONCLUSION: After evaluation of a large patient cohort, we show that age\u226575 years represents a significant risk factor for the detection of clinically significant prostate cancer. Further studies on mid- and long term outcome are necessary to draw conclusions for clinical decision making in this patient cohort.<\/jats:p>","DOI":"10.3233\/ch-238101","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T13:36:43Z","timestamp":1694525803000},"page":"63-70","source":"Crossref","is-referenced-by-count":1,"title":["mpMRI-targeted biopsy of the prostate in men \u2265 75 years. 7-year report from a high-volume referral center"],"prefix":"10.1177","volume":"86","author":[{"given":"Michael","family":"Chaloupka","sequence":"first","affiliation":[{"name":"Department of Urology, LMU Klinikum, Ludwigs-Maximilians University Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Pyrgidis","sequence":"additional","affiliation":[{"name":"Department of Urology, LMU Klinikum, Ludwigs-Maximilians University Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedikt","family":"Ebner","sequence":"additional","affiliation":[{"name":"Department of Urology, LMU Klinikum, Ludwigs-Maximilians University Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo L.","family":"Pfitzinger","sequence":"additional","affiliation":[{"name":"Department of Urology, LMU Klinikum, Ludwigs-Maximilians University Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannic","family":"Volz","sequence":"additional","affiliation":[{"name":"Department of Urology, LMU Klinikum, Ludwigs-Maximilians University Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Urology, LMU Klinikum, Ludwigs-Maximilians University Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benazir","family":"Enzinger","sequence":"additional","affiliation":[{"name":"Department of Urology, LMU Klinikum, Ludwigs-Maximilians University Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Atzler","sequence":"additional","affiliation":[{"name":"Department of Urology, LMU Klinikum, Ludwigs-Maximilians University Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troya","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Department of Urology, LMU Klinikum, Ludwigs-Maximilians University Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo L.","family":"Pfitzinger","sequence":"additional","affiliation":[{"name":"Department of Urology, LMU Klinikum, Ludwigs-Maximilians University Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian G.","family":"Stief","sequence":"additional","affiliation":[{"name":"Department of Urology, LMU Klinikum, Ludwigs-Maximilians University Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Apfelbeck","sequence":"additional","affiliation":[{"name":"Department of Urology, LMU Klinikum, Ludwigs-Maximilians University Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk-Andr\u00e9","family":"Clevert","sequence":"additional","affiliation":[{"name":"Department of Radiology, Interdisciplinary Ultrasound-Center, LMU Klinikum, Ludwigs-Maximilians University Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/CH-238101_ref1","unstructured":"Zentrum f\u00fcr Krebsregisterdaten, Robert Koch Insitut: Krebs in Deutschland - 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