{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T13:00:31Z","timestamp":1778072431543,"version":"3.51.4"},"reference-count":52,"publisher":"SAGE Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CH"],"published-print":{"date-parts":[[2024,7,18]]},"abstract":"<jats:p>OBJECTIVE: This study aimed to investigate the effects of six weeks of continuous training and Nutrition Bio-shield (NBS) Superfood Supplementation on the state of oxidative stress by the expression of Nrf2, NOX4, superoxide dismutase, and malondialdehyde genes in the lungs of rats after methamphetamine withdrawal. METHODS: Forty male Wistar rats were randomly divided into five groups (n\u200a=\u200a8, per group), undergoing methamphetamine administration (six weeks, 5\u200amg\/kg ip, and once per day) followed by a 21-day withdrawal period. The rats were supplemented NBS superfood at a dosage of 25\u200ag\/kg per day for six weeks. The training protocol was 30 minutes of daily continuous training (treadmill running), five days a week for six weeks. The regimen escalated from a pace of 3\u200am\/min for the initial 5 minutes, to 5\u200am\/min for the following 5 minutes, culminating at 8\u200am\/min for the remainder of the session, all at a 0\u00b0 incline. A one-way analysis of variance was performed to analyze the gene expression of Nrf2, NOX4, MDA, and SOD in the lungs tissue of rats. RESULTS: The results indicated that, in the experimental groups which underwent continuous training and NBS Superfood supplementation, the expression of the Nrf2 gene exhibited a significant elevation compared to the control group (P\u200a&lt;\u200a0.05), while the NOX4, MDA, and SOD genes expression exhibited a significant decline in comparison to the control group (P\u200a&lt;\u200a0.05). CONCLUSION: In general, both exercise interventions and NBS superfood supplementation, when employed separately or in combination after methamphetamine withdrawal, can enhance the state of oxidative stress in the lung.<\/jats:p>","DOI":"10.3233\/ch-242306","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T11:45:23Z","timestamp":1721389523000},"page":"1-12","source":"Crossref","is-referenced-by-count":1,"title":["Modulation of pulmonary oxidative status in methamphetamine-withdrawn rats, comparing the effects of continuous training and NBS superfood supplementation"],"prefix":"10.1177","author":[{"given":"Ali","family":"Saydi","sequence":"first","affiliation":[{"name":"Department of Exercise Physiology, Faculty of Sport Sciences, Razi University, Kermanshah, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naser","family":"Behpoor","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, Faculty of Sport Sciences, Razi University, Kermanshah, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Khamis Abadi","sequence":"additional","affiliation":[{"name":"Department of Sport Physiology, Faculty of Human Sciences, Borujerd Branch, Islamic Azad University, Borujerd, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich","family":"Jung","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Brandenburg, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Negin","family":"Kordi","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, Faculty of Sport Sciences, Razi University, Kermanshah, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"4","key":"10.3233\/CH-242306_ref1","doi-asserted-by":"publisher","first-page":"e00400","DOI":"10.1128\/mbio.00400-13","article-title":"Methamphetamine enhances Cryptococcus neoformans pulmonary infection and dissemination to the brain","volume":"4","author":"Patel","year":"2013","journal-title":"MBio"},{"key":"10.3233\/CH-242306_ref2","first-page":"129","article-title":"Pulmonary Arterial hypertension is associated with oxidative stress\u2013 induced genome instability","author":"Van Houten","year":"2015","journal-title":"American Thoracic Society"},{"issue":"349","key":"10.3233\/CH-242306_ref3","first-page":"re8","article-title":"Localizing NADPH oxidase\u2013 derived ROS","volume":"2006","author":"Ushio-Fukai","year":"2006","journal-title":"Science\u2019s STKE"},{"issue":"2","key":"10.3233\/CH-242306_ref4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1203\/PDR.0b013e3181a9eafb","article-title":"Oxygen toxicity and reactive oxygen species: The devil is in the details","volume":"66","author":"Auten","year":"2009","journal-title":"Pediatric Research"},{"issue":"2","key":"10.3233\/CH-242306_ref5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3233\/CH-232007","article-title":"Angiotensin-converting enzyme inhibitors provide a protective effect on hypoxia-induced injury in human coronary artery endothelial cells via Nrf2 signaling and PLVAP","volume":"87","author":"Zhang","year":"2024","journal-title":"Clinical Hemorheology and Microcirculation"},{"issue":"6","key":"10.3233\/CH-242306_ref6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3109\/01902148.2013.792881","article-title":"Moderate hypothermia attenuates oxidative stress injuries in alveolar epithelial A549 cells","volume":"39","author":"Chiou","year":"2013","journal-title":"Experimental Lung Research"},{"issue":"3-4","key":"10.3233\/CH-242306_ref7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.phymed.2012.11.004","article-title":"Ginkgo biloba leaves extract (EGb 761) attenuates lipopolysaccharide-induced acute lung injury via inhibition of oxidative stress and NF-\u03baB-dependent matrix metalloproteinase-9 pathway","volume":"20","author":"Huang","year":"2013","journal-title":"Phytomedicine"},{"issue":"7","key":"10.3233\/CH-242306_ref8","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1177\/0960327112468174","article-title":"Involvement of serotonin mechanism in methamphetamine-induced chronic pulmonary toxicity in rats","volume":"32","author":"Wang","year":"2013","journal-title":"Human & Experimental Toxicology"},{"key":"10.3233\/CH-242306_ref9","first-page":"570650","article-title":"Immunohistochemical study of Nrf2-antioxidant response element as indicator of oxidative stress induced by cadmium in developing rats","author":"Montes","year":"2015","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10.3233\/CH-242306_ref10","doi-asserted-by":"crossref","unstructured":"Choi S . 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