{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:49:59Z","timestamp":1789037399736,"version":"build-2803163510"},"reference-count":31,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CH"],"published-print":{"date-parts":[[2024,4,10]]},"abstract":"<jats:p>BACKGROUND: The continuous development of ultrasound techniques increasingly enables better description and visualization of unclear lesions. New ultrasound systems must be evaluated with regard to all these diagnostic possibilities. METHODS: A multifrequency C1-7 convex probe (SC7-1M) with the new high-end system Resona A20 Series was used. Modern technologies, including HiFR CEUS, SR CEUS and multimodal tissue imaging with shear wave elastography (SWE), fat evaluation and viscosity measurements (M-Ref) were applied. RESULTS: Of n\u200a=\u200a70 (mean value 48,3 years\u00b120,3 years, range 18\u201384 years) cases examined, a definitive diagnosis could be made in n\u200a=\u200a67 cases, confirmed by reference imaging and\/or follow-up. Of these, n\u200a=\u200a22 cases were malignant changes (HCC (hepatocellular carcinoma) n\u200a=\u200a9, CCC (cholangiocellular carcinoma) n\u200a=\u200a3, metastases of colorectal carcinomas or recurrences of HCC n\u200a=\u200a10). In all 12 cases of HCC or CCC, the elastography measurements using the shear wave technique (with values &gt;2\u200am\/s to 3.7\u200am\/s) showed mean values of 2.3\u00b10.31\u200am\/s and a degree of fibrosis of F2 to F4. In n\u200a=\u200a14 cases, changes in the fat measurement (range 0.51 to 0.72\u200adB\/cm\/MHz, mean values 0.58\u00b10.12\u200adB\/cm\/MHz) in the sense of proportional fatty changes in the liver were detected. In the 4 cases of localized fat distribution disorders, the values were &gt;0.7\u200adB\/cm\/MHz in the sense of significant fatty deposits in the remaining liver tissue. Relevant changes in the viscosity measurements with values &gt;1.8\u200akPa were found in n\u200a=\u200a31 cases, in n\u200a=\u200a5 cases of cystic lesions with partially sclerosing cholangitis, in n\u200a=\u200a13 cases of malignant lesions and in n\u200a=\u200a9 cases post-interventionally, but also in n\u200a=\u200a4 cases of benign foci with additional systemic inflammation. CONCLUSIONS: The results are promising and show a new quality of ultrasound-based liver diagnostics. However, there is a need for further investigations with regard to the individual aspects, preferably on a multi-center basis.<\/jats:p>","DOI":"10.3233\/ch-249103","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T12:47:31Z","timestamp":1710247651000},"page":"263-273","source":"Crossref","is-referenced-by-count":21,"title":["Novel high-resolution contrast agent ultrasound techniques HiFR CEUS and SR CEUS in combination with shear wave elastography, fat assessment and viscosity of liver parenchymal changes and tumors"],"prefix":"10.1177","volume":"86","author":[{"given":"Ernst Michael","family":"Jung","sequence":"first","affiliation":[{"name":"Interdisciplinary Ultrasound Department, Institute of Diagnostic Radiology, University Hospital Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Clinic and Polyclinic for Internal Medicine 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