{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:33:30Z","timestamp":1777660410216,"version":"3.51.4"},"reference-count":69,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HAB"],"published-print":{"date-parts":[[2021,3,24]]},"abstract":"<jats:p>Recent advances in assisted reproductive technology (ART) have allowed couples with severe infertility to conceive, but the methods are not effective for all cases. Stem cells as undifferentiated cells which are found in different stages of embryonic, fetal and adult life are known to be capable of forming different cell types, tissues, and organs. Due to their unlimited resources and the incredible power of differentiation are considered as potential new therapeutic biological tools for treatment of infertility. For reproductive medicine, stem cells are stimulated in vitro to develop various specialized functional cells including male and female gametes. The epigenetic patterns can be modified in the genome under certain drugs exposure or lifestyle alterations. Therefore, epigenetics-related disorders may be treated if the nature of the modifications is completely admissible. It is proved that our understanding of epigenetic processes and its association with infertility would help us not only to understand the etiological factors but also to treat some type of male infertilities. Exploration of both genetic and epigenetic variations in the disease development could help in the identification of the interaction patterns between these two phenomena and possible improvement of therapeutic methods.<\/jats:p>","DOI":"10.3233\/hab-200438","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T14:26:45Z","timestamp":1612276005000},"page":"17-26","source":"Crossref","is-referenced-by-count":4,"title":["Infertility cell therapy and epigenetic insights"],"prefix":"10.1177","volume":"29","author":[{"given":"Nahal","family":"Eshghifar","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behnam Kamali","family":"Dehghan","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, National Institute of Medical Engineering and Biotechnology (NIGEB), Tehran, Iran"},{"name":"Medical Genetics, Jiroft University of Medical Sciences and Health Services, Jiroft, Kerman, Iran"},{"name":"Department of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atieh Abedin","family":"Do","sequence":"additional","affiliation":[{"name":"Groupe de Recherche en \u00c9cologie Buccale, Facult\u00e9 de M\u00e9decine Dentaire, Universit\u00e9 Laval, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeideh Zamani","family":"Koukhaloo","sequence":"additional","affiliation":[{"name":"Avicenna Research Institute, Shahid Beheshti University, Evin, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Habibi","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farkhondeh","family":"Pouresmaeili","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/HAB-200438_ref1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12958-015-0032-1","article-title":"A unique view on male infertility around the globe","volume":"13","author":"Agarwal","year":"2015","journal-title":"Reproductive Biology and Endocrinology"},{"key":"10.3233\/HAB-200438_ref2","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1016\/j.fertnstert.2008.03.022","article-title":"Infertility services reported by men in the United States: national survey data","volume":"91","author":"Anderson","year":"2009","journal-title":"Fertility and Sterility"},{"key":"10.3233\/HAB-200438_ref3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2164\/jandrol.110.012351","article-title":"Hormonal imbalances and psychological scars left behind in infertile men","volume":"33","author":"Bak","year":"2012","journal-title":"Journal of Andrology"},{"key":"10.3233\/HAB-200438_ref4","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1477-7827-12-114","article-title":"Making gametes from pluripotent stem cells \u2013 a promising role for very small embryonic-like stem cells","volume":"12","author":"Bhartiya","year":"2014","journal-title":"Reproductive Biology and Endocrinology"},{"key":"10.3233\/HAB-200438_ref5","doi-asserted-by":"crossref","first-page":"59","DOI":"10.5653\/cerm.2016.43.2.59","article-title":"Epigenetics: a key paradigm in reproductive health","volume":"43","author":"Bunkar","year":"2016","journal-title":"Clinical and Experimental Reproductive Medicine"},{"key":"10.3233\/HAB-200438_ref6","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.bbrc.2013.02.107","article-title":"In vitro and in vivo differentiation of induced pluripotent stem cells into male germ cells","volume":"433","author":"Cai","year":"2013","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.3233\/HAB-200438_ref7","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.fertnstert.2011.12.036","article-title":"Epigenetics of the male gamete","volume":"97","author":"Carrell","year":"2012","journal-title":"Fertility and Sterility"},{"key":"10.3233\/HAB-200438_ref8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev-genom-091416-035426","article-title":"Recent advances in mitochondrial disease","volume":"18","author":"Craven","year":"2017","journal-title":"Annual Review of Genomics and Human Genetics"},{"key":"10.3233\/HAB-200438_ref9","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s10815-012-9715-0","article-title":"Epigenetics and its role in male infertility","volume":"29","author":"Dada","year":"2012","journal-title":"Journal of Assisted Reproduction and Genetics"},{"key":"10.3233\/HAB-200438_ref10","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nrendo.2013.205","article-title":"Fertility preservation in women","volume":"9","author":"Donnez","year":"2013","journal-title":"Nature Reviews Endocrinology"},{"key":"10.3233\/HAB-200438_ref12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.rbmo.2013.03.003","article-title":"Stem cell therapeutic possibilities: future therapeutic options for male-factor and female-factor infertility","volume":"27","author":"Easley","year":"2013","journal-title":"Reproductive Biomedicine Online"},{"key":"10.3233\/HAB-200438_ref13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.fertnstert.2013.11.025","article-title":"Adult somatic cells to the rescue: nuclear reprogramming and the dispensability of gonadal germ cells","volume":"101","author":"Easley IV","year":"2014","journal-title":"Fertility and Sterility"},{"key":"10.3233\/HAB-200438_ref14","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.celrep.2012.07.015","article-title":"Direct differentiation of human pluripotent stem cells into haploid spermatogenic cells","volume":"2","author":"Easley IV","year":"2012","journal-title":"Cell Reports"},{"key":"10.3233\/HAB-200438_ref15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.rbmo.2013.03.003","article-title":"Stem cell therapeutic possibilities: future therapeutic options for male-factor and female-factor infertility","volume":"27","author":"Easley IV","year":"2013","journal-title":"Reproductive Biomedicine Online"},{"key":"10.3233\/HAB-200438_ref16","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1002\/stem.672","article-title":"Complete meiosis from human induced pluripotent stem cells","volume":"29","author":"Eguizabal","year":"2011","journal-title":"Stem Cells"},{"key":"10.3233\/HAB-200438_ref18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.6061\/clinics\/2013(Sup01)11","article-title":"An update on sperm retrieval techniques for azoospermic males","volume":"68","author":"Esteves","year":"2013","journal-title":"Clinics"},{"key":"10.3233\/HAB-200438_ref19","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/humrep\/dex369","article-title":"Human induced pluripotent stem cells and male infertility: an overview of current progress and perspectives","volume":"33","author":"Fang","year":"2018","journal-title":"Human Reproduction"},{"key":"10.3233\/HAB-200438_ref20","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1161\/CIRCULATIONAHA.110.956839","article-title":"Epigenetic modifications: basic mechanisms and role in cardiovascular disease","volume":"123","author":"Handy","year":"2011","journal-title":"Circulation"},{"key":"10.3233\/HAB-200438_ref21","first-page":"1222482","article-title":"Offspring from oocytes derived from in vitro primordial germ cell-like cells in mice","author":"Hayashi","year":"2012","journal-title":"Science"},{"key":"10.3233\/HAB-200438_ref22","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.cell.2011.06.052","article-title":"Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells","volume":"146","author":"Hayashi","year":"2011","journal-title":"Cell"},{"key":"10.3233\/HAB-200438_ref23","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1093\/humrep\/der343","article-title":"Separating spermatogonia from cancer cells in contaminated prepubertal primate testis cell suspensions","volume":"26","author":"Hermann","year":"2011","journal-title":"Human Reproduction"},{"key":"10.3233\/HAB-200438_ref24","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.stem.2012.07.017","article-title":"Spermatogonial stem cell transplantation into rhesus testes regenerates spermatogenesis producing functional sperm","volume":"11","author":"Hermann","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.3233\/HAB-200438_ref25","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/humupd\/dmv016","article-title":"Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century","volume":"21","author":"Inhorn","year":"2015","journal-title":"Human Reproduction Update"},{"key":"10.3233\/HAB-200438_ref26","doi-asserted-by":"crossref","first-page":"36","DOI":"10.5966\/sctm.2011-0001","article-title":"From skin biopsy to neurons through a pluripotent intermediate under Good Manufacturing Practice protocols","volume":"1","author":"Karumbayaram","year":"2012","journal-title":"Stem Cells Translational Medicine"},{"key":"10.3233\/HAB-200438_ref27","doi-asserted-by":"crossref","unstructured":"A. Kitamura, N. Miyauchi, H. Hamada, H. Hiura, H. Chiba, H. Okae, A. Sato, R.M. John and T. Arima, Epigenetic alterations in sperm associated with male infertility, Congenital Anomalies 55 (2015), 133\u2013144.","DOI":"10.1111\/cga.12113"},{"key":"10.3233\/HAB-200438_ref28","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3389\/fendo.2018.00347","article-title":"Cryopreservation of ovarian tissue: opportunities beyond fertility preservation and a positive view into the future","volume":"9","author":"Kristensen","year":"2018","journal-title":"Frontiers in Endocrinology"},{"key":"10.3233\/HAB-200438_ref29","doi-asserted-by":"crossref","first-page":"5","DOI":"10.6061\/clinics\/2013(Sup01)02","article-title":"Novel insights into the genetic and epigenetic paternal contribution to the human embryo","volume":"68","author":"Kumar","year":"2013","journal-title":"Clinics"},{"key":"10.3233\/HAB-200438_ref30","doi-asserted-by":"crossref","first-page":"70","DOI":"10.4103\/0974-1208.86080","article-title":"Ovarian hyperstimulation syndrome","volume":"4","author":"Kumar","year":"2011","journal-title":"Journal of Human Reproductive Sciences"},{"key":"10.3233\/HAB-200438_ref31","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s13023-015-0332-8","article-title":"Immunosuppressive drugs and fertility","volume":"10","author":"Leroy","year":"2015","journal-title":"Orphanet Journal of Rare Diseases"},{"key":"10.3233\/HAB-200438_ref32","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3390\/children1020166","article-title":"Preserving fertility in children and adolescents with cancer","volume":"1","author":"Levine","year":"2014","journal-title":"Children"},{"key":"10.3233\/HAB-200438_ref33","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.scr.2013.12.007","article-title":"Generation of male germ cells from mouse induced pluripotent stem cells in vitro","volume":"12","author":"Li","year":"2014","journal-title":"Stem Cell Research"},{"key":"10.3233\/HAB-200438_ref36","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/0974-1208.153119","article-title":"Fertility preservation in female cancer patients: an overview","volume":"8","author":"Mahajan","year":"2015","journal-title":"Journal of Human Reproductive Sciences"},{"key":"10.3233\/HAB-200438_ref37","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.aju.2017.11.013","article-title":"Systematic review of antioxidant types and doses in male infertility: benefits on semen parameters, advanced sperm function, assisted reproduction and live-birth rate","volume":"16","author":"Majzoub","year":"2018","journal-title":"Arab Journal of Urology"},{"key":"10.3233\/HAB-200438_ref38","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.fertnstert.2009.01.002","article-title":"Imprinting disorders and assisted reproductive technology","volume":"91","author":"Manipalviratn","year":"2009","journal-title":"Fertility and Sterility"},{"key":"10.3233\/HAB-200438_ref39","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4103\/0970-1591.78430","article-title":"In vitro fertilization\/intracytoplasmic sperm injection for male infertility","volume":"27","author":"Merchant","year":"2011","journal-title":"Indian Journal of Urology: IJU: Journal of the Urological Society of India"},{"key":"10.3233\/HAB-200438_ref40","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1093\/humrep\/des466","article-title":"Reproductive characteristics in relation to ovarian cancer risk by histologic pathways","volume":"28","author":"Merritt","year":"2013","journal-title":"Human Reproduction"},{"key":"10.3233\/HAB-200438_ref41","doi-asserted-by":"crossref","unstructured":"S. Minocherhomji, P.F. Madon and F.R. Parikh, Epigenetic regulatory mechanisms associated with infertility, Obstetrics and Gynecology International 2010 (2010).","DOI":"10.1155\/2010\/198709"},{"key":"10.3233\/HAB-200438_ref42","first-page":"246","article-title":"Role of epigenetics in biology and human diseases","volume":"20","author":"Moosavi","year":"2016","journal-title":"Iranian Biomedical Journal"},{"key":"10.3233\/HAB-200438_ref43","doi-asserted-by":"crossref","first-page":"33","DOI":"10.5653\/cerm.2015.42.2.33","article-title":"Artificial gametes from stem cells","volume":"42","author":"Moreno","year":"2015","journal-title":"Clinical and Experimental Reproductive Medicine"},{"key":"10.3233\/HAB-200438_ref44","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1089\/scd.2015.0230","article-title":"In vitro gamete differentiation from pluripotent stem cells as a promising therapy for infertility","volume":"25","author":"Mouka","year":"2016","journal-title":"Stem Cells and Development"},{"key":"10.3233\/HAB-200438_ref45","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.devcel.2006.05.010","article-title":"In vitro-differentiated embryonic stem cells give rise to male gametes that can generate offspring mice","volume":"11","author":"Nayernia","year":"2006","journal-title":"Developmental Cell"},{"key":"10.3233\/HAB-200438_ref46","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/MED.0b013e32834040a3","article-title":"Imprinting disorders and assisted reproductive technology","volume":"17","author":"Odom","year":"2010","journal-title":"Current Opinion in Endocrinology, Diabetes, and Obesity"},{"key":"10.3233\/HAB-200438_ref47","doi-asserted-by":"crossref","first-page":"e113671","DOI":"10.1371\/journal.pone.0113671","article-title":"Intracytoplasmic sperm injection (ICSI) in extreme cases of male infertility","volume":"9","author":"Palermo","year":"2014","journal-title":"PLoS One"},{"key":"10.3233\/HAB-200438_ref48","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1744-4667.2012.00153.x","article-title":"Ovarian hyperstimulation syndrome","volume":"15","author":"Prakash","year":"2013","journal-title":"The Obstetrician & Gynaecologist"},{"key":"10.3233\/HAB-200438_ref49","first-page":"18","article-title":"Causes of male infertility: a 9-year prospective monocentre study on 1737 patients with reduced total sperm counts","volume":"32","author":"Punab","year":"2016","journal-title":"Human Reproduction"},{"key":"10.3233\/HAB-200438_ref50","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.mrrev.2011.04.002","article-title":"Epigenetics, spermatogenesis and male infertility","volume":"727","author":"Rajender","year":"2011","journal-title":"Mutation Research\/Reviews in Mutation Research"},{"key":"10.3233\/HAB-200438_ref51","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.celrep.2014.03.067","article-title":"Fate of iPSCs derived from azoospermic and fertile men following xenotransplantation to murine seminiferous tubules","volume":"7","author":"Ramathal","year":"2014","journal-title":"Cell Reports"},{"key":"10.3233\/HAB-200438_ref52","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s10815-017-0931-5","article-title":"Genetics and epigenetics of varicocele pathophysiology: an overview","volume":"34","author":"Santana","year":"2017","journal-title":"Journal of Assisted Reproduction and Genetics"},{"key":"10.3233\/HAB-200438_ref53","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.tig.2016.04.006","article-title":"Mitochondrial replacement techniques: divergence in global policy","volume":"32","author":"Schandera","year":"2016","journal-title":"Trends in Genetics"},{"key":"10.3233\/HAB-200438_ref54","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/embor.2012.198","article-title":"Cellular promiscuity: explaining cellular fidelity in vivo against unrestrained pluripotency in vitro","volume":"14","author":"Schatten","year":"2013","journal-title":"EMBO Reports"},{"key":"10.3233\/HAB-200438_ref55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13048-015-0184-9","article-title":"Perspective in infertility: the ovarian stem cells","volume":"8","author":"Silvestris","year":"2015","journal-title":"Journal of Ovarian Research"},{"key":"10.3233\/HAB-200438_ref56","first-page":"211","article-title":"Fertility preservation options for men and women with cancer","volume":"17","author":"Skaznik-Wikiel","year":"2015","journal-title":"Reviews in Urology"},{"key":"10.3233\/HAB-200438_ref57","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/bdrc.20199","article-title":"Role of epigenetics in developmental biology and transgenerational inheritance","volume":"93","author":"Skinner","year":"2011","journal-title":"Birth Defects Research Part C: Embryo Today: Reviews"},{"key":"10.3233\/HAB-200438_ref58","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.12659\/MSM.904098","article-title":"Non-invasive approaches to epigenetic-based sperm selection","volume":"23","author":"\u0160tiavnick\u00e1","year":"2017","journal-title":"Medical Science Monitor: International Medical Journal of Experimental and Clinical Research"},{"key":"10.3233\/HAB-200438_ref59","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/jlb\/lsv057","article-title":"In vitro gametogenesis: just another way to have a baby","volume":"3","author":"Suter","year":"2016","journal-title":"Journal of Law and the Biosciences"},{"key":"10.3233\/HAB-200438_ref60","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nature11647","article-title":"Towards germline gene therapy of inherited mitochondrial diseases","volume":"493","author":"Tachibana","year":"2013","journal-title":"Nature"},{"key":"10.3233\/HAB-200438_ref61","doi-asserted-by":"crossref","unstructured":"A. Tanaka, M. Nagayoshi, Y. Takemoto, I. Tanaka, H. Kusunoki, S. Watanabe, K. Kuroda, S. Takeda, M. Ito and R. Yanagimachi, Fourteen babies born after round spermatid injection into human oocytes, Proceedings of the National Academy of Sciences 112 (2015), 14629\u201314634.","DOI":"10.1073\/pnas.1517466112"},{"key":"10.3233\/HAB-200438_ref62","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nrg.2016.88","article-title":"Specification and epigenetic programming of the human germ line","volume":"17","author":"Tang","year":"2016","journal-title":"Nature Reviews Genetics"},{"key":"10.3233\/HAB-200438_ref64","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.fertnstert.2013.01.125","article-title":"Are imprinting disorders more prevalent after human in vitro fertilization or intracytoplasmic sperm injection","volume":"99","author":"Vermeiden","year":"2013","journal-title":"Fertility and Sterility"},{"key":"10.3233\/HAB-200438_ref65","first-page":"374151","article-title":"Possible therapeutic use of spermatogonial stem cells in the treatment of male infertility: a brief overview","volume":"2012","author":"Vlajkovi\u0107","year":"2012","journal-title":"The Scientific WorldJournal"},{"key":"10.3233\/HAB-200438_ref66","doi-asserted-by":"crossref","unstructured":"V. Volarevic, S. Bojic, J. Nurkovic, A. Volarevic, B. Ljujic, N. Arsenijevic, M. Lako and M. Stojkovic, Stem cells as new agents for the treatment of infertility: current and future perspectives and challenges, BioMed Research International 2014 (2014).","DOI":"10.1155\/2014\/507234"},{"key":"10.3233\/HAB-200438_ref67","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1095\/biolreprod.109.078717","article-title":"Critical function of AP-2gamma\/TCFAP2C in mouse embryonic germ cell maintenance","volume":"82","author":"Weber","year":"2010","journal-title":"Biology of Reproduction"},{"key":"10.3233\/HAB-200438_ref68","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nm.2669","article-title":"Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women","volume":"18","author":"White","year":"2012","journal-title":"Nature Medicine"},{"key":"10.3233\/HAB-200438_ref69","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.cmet.2014.06.012","article-title":"Mitochondrial replacement therapies can circumvent mtDNA-based disease transmission","volume":"20","author":"Wolf","year":"2014","journal-title":"Cell Metabolism"},{"key":"10.3233\/HAB-200438_ref70","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/nprot.2013.047","article-title":"Isolation, characterization and propagation of mitotically active germ cells from adult mouse and human ovaries","volume":"8","author":"Woods","year":"2013","journal-title":"Nature Protocols"},{"key":"10.3233\/HAB-200438_ref71","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1016\/j.fertnstert.2013.01.145","article-title":"Time costs of fertility care: the hidden hardship of building a family","volume":"99","author":"Wu","year":"2013","journal-title":"Fertility and Sterility"},{"key":"10.3233\/HAB-200438_ref72","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1365-2184.2012.00811.x","article-title":"Derivation of male germ cells from induced pluripotent stem cells in vitro and in reconstituted seminiferous tubules","volume":"45","author":"Yang","year":"2012","journal-title":"Cell Proliferation"},{"key":"10.3233\/HAB-200438_ref73","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.stem.2016.01.017","article-title":"Complete meiosis from embryonic stem cell-derived germ cells in vitro","volume":"18","author":"Zhou","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.3233\/HAB-200438_ref74","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s40142-013-0027-1","article-title":"The genetics of infertility: current status of the field","volume":"1","author":"Zorrilla","year":"2013","journal-title":"Current Genetic Medicine Reports"}],"container-title":["Human Antibodies"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/HAB-200438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:22:25Z","timestamp":1777447345000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/HAB-200438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,24]]},"references-count":69,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3233\/hab-200438","relation":{},"ISSN":["1875-869X","1093-2607"],"issn-type":[{"value":"1875-869X","type":"electronic"},{"value":"1093-2607","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3,24]]}}}