{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:23:48Z","timestamp":1787063028562,"version":"build-2736575974"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HAB"],"published-print":{"date-parts":[[2024,1,25]]},"abstract":"<jats:p>BACKGROUND: The COVID-19 pandemic, caused by the new virus of the coronavirus family, SARS-CoV-2, could lead to acute respiratory syndrome. The molecular mechanisms related to this disorder are still debatable. METHODS: In this study to understand the pathogenicity mechanism of SARS-CoV-2, using the bioinformatics approaches, we investigated the expression of involved genes, their regulatory, and main signaling pathways during the time on days\u00a01, 2, 3, and 4 of SARS-CoV infected cells. RESULTS: Here, our investigation shows the complex changes in gene expression on days 2 and 3\u00a0post-infection. The functional analysis showed that especially related to immune response, response to other organisms, and defense response. IL6-AS1 is the predicted long non-coding RNA and is a key regulator during infection. In this study, for the first time has been reported the role of IL6-AS1. Also, the correlation of differential expression genes with the level of immune infiltration was shown in the relationship of Natural killer cells and T cell CD 4+ with DE genes. CONCLUSION: In the current study, identification of the altered expression pattern of genes in SARS-CoV-infected cells in time course also can help identify and link the molecular mechanisms and explore the holistic view of infection of SARS-CoV-2.<\/jats:p>","DOI":"10.3233\/hab-230012","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T12:16:37Z","timestamp":1702988197000},"page":"81-88","source":"Crossref","is-referenced-by-count":1,"title":["Time-series bioinformatics analysis of SARS-CoV-infected cells to identify the biological processes associated with severe acute respiratory syndrome"],"prefix":"10.1177","volume":"31","author":[{"given":"Razieh","family":"Fatehi","sequence":"first","affiliation":[{"name":"Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farinaz","family":"Khosravian","sequence":"additional","affiliation":[{"name":"Cellular, Molecular and Genetics Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"},{"name":"Medical Genetics Research Center of Genome, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansoor","family":"Salehi","sequence":"additional","affiliation":[{"name":"Cellular, Molecular and Genetics Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"},{"name":"Medical Genetics Research Center of Genome, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Kazemi","sequence":"additional","affiliation":[{"name":"Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran"},{"name":"Reproductive Sciences and Sexual Health Research Center, Isfahan University of Medical Science, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"issue":"13","key":"10.3233\/HAB-230012_ref1","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1056\/NEJMoa2001316","article-title":"Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia","volume":"382","author":"Li","year":"2020","journal-title":"N Engl J Med"},{"issue":"7798","key":"10.3233\/HAB-230012_ref2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41586-020-2008-3","article-title":"A new coronavirus associated with human respiratory disease in China","volume":"579","author":"Wu","year":"2020","journal-title":"Nature"},{"key":"10.3233\/HAB-230012_ref3","doi-asserted-by":"crossref","unstructured":"L.F. 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