{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:04:34Z","timestamp":1787025874002,"version":"build-2736575974"},"reference-count":43,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HAB"],"published-print":{"date-parts":[[2024,6,11]]},"abstract":"<jats:p>BACKGROUND: Anti-mutated citrullinated vimentin (MCV) antibodies have recently been recommended as a better arthritis diagnostic marker. OBJECTIVES: To investigate the association between anti-MCV antibodies and the clinical, functional, and radiographic characteristics of rheumatoid arthritis (RA) patients. METHODS: This case-control study was conducted on 40\u00a0RA\u00a0patients and 40\u00a0healthy subjects. All patients were subjected to an assessment of disease using the 28-joint DAS (DAS28) and Clinical Disease Activity Index (CDAI), function by HAQ-DI, physical activity by International Physical Activity Questionnaire (IPAQ), fatigue by Functional Assessment of Chronic Illness Therapy (FACIT), serological tests as well as anti-MCV Abs measurement. A plain X-ray of both hands and wrists was done. RESULTS: The anti-MCV Abs level was significantly higher in RA patients than in healthy controls (P&lt; 0.001). The anti-MCV Abs had a significant positive correlation with DAS, CDAI, HAQ, RF, Anti-CCP, and CRP (P= 0.006, 0.013, 0.005, &lt; 0.001, &lt; 0.001and 0.041\u00a0respectively) and a significant negative correlation with FACIT (p= 0.007). Positive anti-MCV RA patients had significantly higher erosions, JSN, and a total sharp score. CONCLUSIONS: Anti-MCV Abs may contribute to poor physical activity and more fatigue in RA patients beyond their established role in disease activity and erosion.<\/jats:p>","DOI":"10.3233\/hab-240007","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T13:56:45Z","timestamp":1714139805000},"page":"75-83","source":"Crossref","is-referenced-by-count":4,"title":["Clinical significance of anti-mutated citrullinated vimentin antibodies in rheumatoid arthritis patients"],"prefix":"10.1177","volume":"32","author":[{"given":"Amira","family":"Hagras","sequence":"first","affiliation":[{"name":"Department Rheumatology, Rehabilitation, and Physical Medicine, Faculty of Medicine Alexandria University, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dia","family":"Mohasseb","sequence":"additional","affiliation":[{"name":"Department Rheumatology, Rehabilitation, and Physical Medicine, Faculty of Medicine Alexandria University, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghda","family":"Taleb","sequence":"additional","affiliation":[{"name":"Department Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rim","family":"Bastawi","sequence":"additional","affiliation":[{"name":"Department Radiodiagnosis and Intervention, Faculty of Medicine, Alexandria University, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab","family":"Elnemr","sequence":"additional","affiliation":[{"name":"Department Rheumatology, Rehabilitation, and Physical Medicine, Faculty of Medicine Alexandria University, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/HAB-240007_ref1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.21608\/ejrci.2014.9983","article-title":"The diagnostic utility of anti-mutated citrullinated vimentin antibodies, anti-cyclic citrullinated peptide antibodies and rheumatoid factor in rheumatoid arthritis","volume":"2","author":"Badr Eldin","year":"2014","journal-title":"Egyptian Journal of Rheumatology and Clinical Immunology"},{"key":"10.3233\/HAB-240007_ref2","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1136\/annrheumdis-2014-206047","article-title":"Evaluating relationships between symptom duration and persistence of rheumatoid arthritis: does a window of opportunity exist? 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