{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:36:11Z","timestamp":1777660571945,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"3-4","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Human Antibodies"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The autoimmune disorder known as Graves\u2019 disease. The condition is due to the binding of thyroid-stimulating immunoglobulins to the thyrotropin receptor located on the thyroid gland. The result is an excess of thyroidal hormones. symptoms of hyperthyroidism, and the formation of diffuse goiter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>This research intends to quantify the levels of CD40L, TSAB in people who suffer from Graves\u2019 disease. It also aims to determine the relationship between TSAB and the duration of the disease, as well as analyze the role of CD40L as a predictive marker for Graves\u2019 disease using medcalc Statistical Software version 16.4.3 and SAS (2018).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>In a case-control study, randomly selected 90 graves disease patients were included, the randomly selected patients were divided equally and matched into a case group who have graves disease and graves disease-free patients as a control group. For both groups whole blood sample was examined to compare for (TSAB), and (CD40L) levels determination by ELISA technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The average serum levels of CD40L showed a highly significant correlation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value &lt; 0.01) among the groups examined for Graves\u2019 disease. The patient group consisted of 13\u00a0males (28.89%) and 32\u00a0females (71.11%). No significant correlation was identified between TSAB and the duration of the condition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Thyroid stimulating antibody (TSAb) test and ultrasonography of the thyroid gland are valuable diagnostic techniques for autoimmune Graves\u2019 disease (GD). CD40L could potentially serve as a predictive diagnostic marker for Graves\u2019 disease. However, there is no observed link between the duration of the disease and the concentration of TSAB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/hab-240036","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T10:38:43Z","timestamp":1729852723000},"page":"63-67","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of CD40L and TSAB serum level in Graves disease patients"],"prefix":"10.1177","volume":"33","author":[{"given":"Alkhansaa Tariq","family":"Jawad","sequence":"first","affiliation":[{"name":"University of Aliraqia","place":["Iraq"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayfaa Mahmood","family":"Fahad","sequence":"additional","affiliation":[{"name":"University of Tikrit","place":["Iraq"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayat Ali","family":"Salih","sequence":"additional","affiliation":[{"name":"??"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"1","article-title":"Graves disease","volume":"20","author":"Pokhrel B.","year":"2023","unstructured":"Pokhrel B., Bhusal K., Graves disease, Nih Gov 20 (2023), 1\u201313. https:\/\/wwwncbi.nlm.nih.gov\/books\/NBK448195\/.","journal-title":"Nih Gov"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0184-y"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","unstructured":"Tamer Mohamed Elsherbiny Characterization treatment preferences and outcomes of 390 Egyptian Graves\u2019 disease patients: a retrospective study The Egyptian Journal of Internal Medicine (Print) 8 (2023) 20\u201328. doi: 10.1186\/s43162-023-00244-x.","DOI":"10.1186\/s43162-023-00244-x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40658-020-0274-7"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000490384"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells12060918"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2020."},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-023-00547-2"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.83.4.4732"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/08916930400002386"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2006.02.002"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/08820130601069715"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.22190"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2021.06.017"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-161745"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02417.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz013"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1510030"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065x.2009.00782.x"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/08820130601069715"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.galenos.2019.2019.0108"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1159\/000508789"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.22190"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz292"}],"container-title":["Human Antibodies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/HAB-240036","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/HAB-240036","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/HAB-240036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:22:52Z","timestamp":1777447372000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/HAB-240036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,23]]},"references-count":24,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.3233\/HAB-240036"],"URL":"https:\/\/doi.org\/10.3233\/hab-240036","relation":{},"ISSN":["1093-2607","1875-869X"],"issn-type":[{"value":"1093-2607","type":"print"},{"value":"1875-869X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,23]]}}}