{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:36:27Z","timestamp":1777394187030,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T00:00:00Z","timestamp":1369094400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2013,5,21]]},"abstract":"<jats:p>The transgenic TgCRND8 mouse is widely used as an animal model of Alzheimer's disease (AD) and exhibits an early onset of senile plaque pathogenesis in the brain. Here we report that TgCRND8 mice also have amyloid-\u03b2 (A\u03b2) neuropathology in spinal cord. TgCRND8 mice began to show obvious A\u03b2 deposition in both gray matter of dorsal horn and white matter in the central part of dorsal column of the spinal cord at 10 months of age onward. Further experiments showed that the distribution of A\u03b2 deposition in the spinal cord corresponds to the corticospinal tract pathway and its projection regions in TgCRND8 mice. We hypothesized that neurons in the sensorimotor cortex is the source of the A\u03b2 peptide deposited in the spinal cord of these mice. To test the hypothesis, we ablated the sensorimotor cortex to interrupt connections between the sensorimotor cortex and spinal cord. We found that A\u03b2 burden was significantly reduced in the denervated side compared to the contralateral side. Our results suggest that the sensorimotor cortex might be the primary source of A\u03b2 in spinal cord of TgCRND8 mice. This is consistent with the observation that the sensorimotor cortex is one region particularly vulnerable during the progression of AD. The characteristics of A\u03b2 distribution in TgCRND8 mice suggest that there are other ways related to the formation of A\u03b2 plaques in addition to the terminal and synaptic release of A\u03b2.<\/jats:p>","DOI":"10.3233\/jad-122323","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T11:36:46Z","timestamp":1528112206000},"page":"675-685","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Amyloid Pathology in Spinal Cord of the Transgenic Alzheimer's Disease Mice is Correlated to the Corticospinal Tract Pathway"],"prefix":"10.1177","volume":"35","author":[{"given":"Qiuju","family":"Yuan","sequence":"first","affiliation":[{"name":"Faculty of Science, School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanxing","family":"Su","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yalun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Development and Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wing Hin","family":"Chau","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Development and Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheung Toa","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Development and Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You-Qiang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Development and Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China"},{"name":"State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Dong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Development and Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China"},{"name":"Research Center of Reproduction, Development and Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wutian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Development and Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China"},{"name":"State Key Laboratory of Brain and Cognitive Sciences, Development and Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China"},{"name":"Research Center of Reproduction, Development and Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China"},{"name":"GHM Institute of CNS Regeneration, Jinan University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Xiu","family":"Lin","sequence":"additional","affiliation":[{"name":"Faculty of Science, School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,5,21]]},"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-122323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-122323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:02:38Z","timestamp":1777370558000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-122323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,21]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,5,21]]}},"alternative-id":["10.3233\/JAD-122323"],"URL":"https:\/\/doi.org\/10.3233\/jad-122323","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,21]]}}}