{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:38:09Z","timestamp":1777394289255,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T00:00:00Z","timestamp":1375660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2013,8,5]]},"abstract":"<jats:p>Alzheimer's disease (AD) is a progressive neurodegenerative disease that takes the form of a local overexpression of cytokines and other inflammatory molecules. We investigated three single-nucleotide polymorphisms (SNP) of the interleukin 6 gene (IL-6) promoter region [\u2212174G\/C (rs 1800795), \u2212572C\/G (rs 1800796), and \u2212597G\/A (rs 1800797)] in 200 patients with late-onset AD and 165 elderly controls in a Brazilian case-control population sample. Genotyping was carried out from blood cells using PCR-RFLP techniques. Statistical analysis was performed to evaluate the Hardy-Weinberg equilibrium and to compare frequencies between groups. No association was found between any IL-6 polymorphism and AD; however the haplotype composed of the \u2212597 A allele and the \u2212174G allele indicated a crude odds ratio (OR) of 0.15 (p = 0.0021) and a significantly adjusted OR (adjusted for the APOE E4 allele value) of 0.15 (p = 0.00294). Linkage disequilibrium was D' = 0.68 among the three SNPs. Our findings revealed a protective effect of AG (\u2212597A, \u2212174G) haplotype, which worked independently of the APOE E4 allele in our Brazilian population sample. Thus, the promoter region of IL-6 gene probably exerts an effect through gene linkage and\/or gene interaction.<\/jats:p>","DOI":"10.3233\/jad-122407","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T11:47:16Z","timestamp":1528112836000},"page":"733-738","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Association Between Interleukin 6 Gene Haplotype and Alzheimer's Disease: A Brazilian Case-Control Study"],"prefix":"10.1177","volume":"36","author":[{"given":"Lucas","family":"Rasmussen","sequence":"first","affiliation":[{"name":"Universidade do Sagrado Cora\u00e7\u00e3o (USC), Bauru, S\u00e3o Paulo, Brazil"},{"name":"Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Delabio","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Marilia (FAMEMA) - Hemocentro, Mar\u00edlia, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lie","family":"Horiguchi","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Marilia (FAMEMA) - Hemocentro, Mar\u00edlia, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Mizumoto","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Marilia (FAMEMA) - Hemocentro, Mar\u00edlia, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos-Renato","family":"Terazaki","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Marilia (FAMEMA) - Hemocentro, Mar\u00edlia, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Mazzotti","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo-Henrique","family":"Bertolucci","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela-Augusta","family":"Pinhel","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Bioqu\u00edmica e Biologia Molecular da Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorot\u00e9ia","family":"Souza","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Bioqu\u00edmica e Biologia Molecular da Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrique","family":"Krieger","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo (USP), S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Kawamata","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo (USP), S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thais","family":"Minett","sequence":"additional","affiliation":[{"name":"University of Cambridge, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilia Cardoso","family":"Smith","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spencer-Luiz","family":"Pay\u00e3o","sequence":"additional","affiliation":[{"name":"Universidade do Sagrado Cora\u00e7\u00e3o (USC), Bauru, S\u00e3o Paulo, Brazil"},{"name":"Faculdade de Medicina de Marilia (FAMEMA) - Hemocentro, Mar\u00edlia, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,8,5]]},"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-122407","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-122407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:02:53Z","timestamp":1777370573000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-122407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,5]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8,5]]}},"alternative-id":["10.3233\/JAD-122407"],"URL":"https:\/\/doi.org\/10.3233\/jad-122407","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,5]]}}}