{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:03:09Z","timestamp":1791331389380,"version":"4.3.1"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T00:00:00Z","timestamp":1369094400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2013,5,21]]},"abstract":"<jats:p>\n                    The specific CB\n                    <jats:sub>2<\/jats:sub>\n                    cannabinoid receptor agonist JWH-133 induced cognitive improvement in double A\u03b2PP\/PS1 transgenic mice, a genetic model of Alzheimer's disease. This effect was more pronounced when administered at the pre-symptomatic rather than the early symptomatic stage. The cognitive improvement was associated with decreased microglial reactivity and reduced expression of pro-inflammatory cytokines IL-1\u03b2, IL-6, TNF\u03b1, and IFN\u03b3. In addition, JWH-133 reduced the expression of active p38 and SAPK\/JNK, increased the expression of inactive GSK3\u03b2, and lowered tau hyperphosphorylation at Thr181 in the vicinity of amyloid-\u03b2 plaques. Moreover, JWH-133 produced a decrease in the expression of hydroxynonenal adducts, and enhanced the expression of SOD1 and SOD2 around plaques. In contrast, the chronic treatment with JWH-133 failed to modify the amyloid-\u03b2 production or deposition in cortex and hippocampus. In conclusion, the present study lends support to the idea that stimulation of CB\n                    <jats:sub>2<\/jats:sub>\n                    receptors ameliorates several altered parameters in Alzheimer's disease such as impaired memory and learning, neuroinflammation, oxidative stress damage and oxidative stress responses, selected tau kinases, and tau hyperphosphorylation around plaques.\n                  <\/jats:p>","DOI":"10.3233\/jad-130137","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T06:05:12Z","timestamp":1528092312000},"page":"847-858","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":195,"title":["CB\n                    <sub>2<\/sub>\n                    Cannabinoid Receptor Agonist Ameliorates Alzheimer-Like Phenotype in A\u03b2PP\/PS1 Mice"],"prefix":"10.1177","volume":"35","author":[{"given":"Ester","family":"Aso","sequence":"first","affiliation":[{"name":"Institut de Neuropatologia, Servei d'Anatomia Patol\u00f2gica, IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Juv\u00e9s","sequence":"additional","affiliation":[{"name":"Institut de Neuropatologia, Servei d'Anatomia Patol\u00f2gica, IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain"},{"name":"CIBERNED, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Neurodegenerativas, Instituto Carlos III, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Laboratori de Neurofarmacologia, Departament de Ci\u00e8ncies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isidro","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Institut de Neuropatologia, Servei d'Anatomia Patol\u00f2gica, IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain"},{"name":"CIBERNED, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Neurodegenerativas, Instituto Carlos III, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,5,21]]},"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-130137","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-130137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:02:39Z","timestamp":1777370559000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-130137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,21]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,5,21]]}},"alternative-id":["10.3233\/JAD-130137"],"URL":"https:\/\/doi.org\/10.3233\/jad-130137","relation":{"is-cited-by":[{"id-type":"doi","id":"10.3389\/fnins.2016.00243","asserted-by":"object"},{"id-type":"doi","id":"10.1155\/2014\/971750","asserted-by":"object"},{"id-type":"doi","id":"10.1007\/s12035-017-0676-2","asserted-by":"object"}]},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,21]]}}}