{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:06:37Z","timestamp":1791338797003,"version":"4.3.1"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T00:00:00Z","timestamp":1386633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2013,12,10]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Dental infections are frequent and have recently been implicated as a possible risk factor for Alzheimer\u2019s disease (AD). Despite a lack of studies investigating orofacial pain in this patient group, dental conditions are known to be a potential cause of pain and to affect quality of life and disease progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To evaluate oral status, mandibular function and orofacial pain in patients with mild AD versus healthy subjects matched for age and gender.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Twenty-nine patients and 30 control subjects were evaluated. The protocol comprised a clinical questionnaire and dental exam, research diagnostic criteria for temporomandibular disorders, the McGill Pain Questionnaire, the decayed, missing, and filled teeth index, and included a full periodontal evaluation. AD signs and symptoms as well as associated factors were evaluated by a trained neurologist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A higher prevalence of orofacial pain (20.7%, p &lt; 0.001), articular abnormalities in temporomandibular joints (p &lt; 0.05), and periodontal infections (p = 0.002) was observed in the study group compared to the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Orofacial pain and periodontal infections were more frequent in patients with mild AD than in healthy subjects. Orofacial pain screening and dental and oral exams should be routinely performed in AD patients in order to identify pathological conditions that need treatment thus improving quality of life compromised due to dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-131283","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T06:15:27Z","timestamp":1528092927000},"page":"823-829","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":50,"title":["Oral Infections and Orofacial Pain in Alzheimer's Disease: A Case-Control Study"],"prefix":"10.1177","volume":"38","author":[{"given":"Tha\u00eds","family":"de Souza Rolim","sequence":"first","affiliation":[{"name":"Orofacial Team, Hospital das Cl\u00ednicas, and Neurology Department, School of Medicine, University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisele Maria Campos","family":"Fabri","sequence":"additional","affiliation":[{"name":"Dentistry Division, Central Institute, Hospital das Clinicas, School of Medicine, University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Nitrini","sequence":"additional","affiliation":[{"name":"Cognitive Neurology and Behavior Group, Hospital das Cl\u00ednicas, and Neurology Department, School of Medicine, University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Anghinah","sequence":"additional","affiliation":[{"name":"Cognitive Neurology and Behavior Group, Neurology Division, Hospital das Cl\u00ednicas, School of Medicine, University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoel Jacobsen","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Functional Neurosurgery Division, Psychiatry Institute of Hospital das Clinicas and Neurology Department, School of Medicine, University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Tadeu T.","family":"de Siqueira","sequence":"additional","affiliation":[{"name":"Orofacial Pain Team of Dentistry Division and Group of Oral Medicine and Neuroscience of the Dentistry Division of the Psychiatry Institute, Hospital das Clinicas, School of Medicine, University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Augusto Ferrari","family":"Cestari","sequence":"additional","affiliation":[{"name":"Group of Oral Medicine and Neuroscience of the Dentistry Division of the Psychiatry Institute, Hospital das Clinicas, School of Medicine, University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Regina Dowgan T.","family":"de Siqueira","sequence":"additional","affiliation":[{"name":"Gerontology, School of Arts, Sciences and Humanities of the University of Sao Paulo, and Group of Oral Medicine and Neuroscience of the Dentistry Division of the Psychiatry Institute, Hospital das Clinicas, School of Medicine, University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,12,10]]},"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-131283","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-131283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:03:32Z","timestamp":1777370612000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-131283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,10]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,12,10]]}},"alternative-id":["10.3233\/JAD-131283"],"URL":"https:\/\/doi.org\/10.3233\/jad-131283","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,10]]}}}