{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:59:48Z","timestamp":1791140388390,"version":"4.1.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T00:00:00Z","timestamp":1400457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2014,5,19]]},"abstract":"<jats:p>\n                    Changes in the concentrations of amyloid-\u03b2 (A\u03b2) in the body fluids are the earliest alterations observed in Alzheimer's disease (AD), however, there is a lack of data about how early these alterations occur, before the onset of the clinical symptoms. APOE genotype is the most recognized genetic risk\/protective factor of AD, meaning that a group of non-demented persons carrying \u03b54 allele is enriched in the subjects who will develop AD, compared to the group of non-carriers. Therefore, we studied the plasma concentrations of A\u03b2 peptides (A\u03b2\n                    <jats:sub>1-42<\/jats:sub>\n                    , A\u03b2\n                    <jats:sub>1-40<\/jats:sub>\n                    , A\u03b2\n                    <jats:sub>x-42<\/jats:sub>\n                    , and A\u03b2\n                    <jats:sub>x-40<\/jats:sub>\n                    ), and the APOE genotype in 173 young volunteers (average age, 28 \u00b1 7.6 years) without memory deficits, in order to see whether the non-demented group of subjects at risk already characterize with A\u03b2 changes three-to-four decades before the age at which dementia usually occurs. We did not find statistically significant differences among the groups of \u03b54 carriers, \u03b53 homozygotes, and \u03b52 carriers. We conclude that the APOE genotype does not influence the metabolism of the A\u03b2 peptides in young persons without memory deficits.\n                  <\/jats:p>","DOI":"10.3233\/jad-132687","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T12:43:57Z","timestamp":1528116237000},"page":"1055-1060","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Plasma Concentrations of the Amyloid-\u03b2 Peptides in Young Volunteers: The Influence of the APOE Genotype"],"prefix":"10.1177","volume":"40","author":[{"given":"Ruediger","family":"Zimmermann","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Universit\u00e4tsklinikum Erlangen, and Friedrich-Alexander Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Universit\u00e4tsklinikum Erlangen, and Friedrich-Alexander Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Schamber","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Universit\u00e4tsklinikum Erlangen, and Friedrich-Alexander Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Lelental","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Universit\u00e4tsklinikum Erlangen, and Friedrich-Alexander Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Mroczko","sequence":"additional","affiliation":[{"name":"Department of Neurodegeneration Diagnostics, Medical University of Bia\u0142ystok, and Department of Biochemical Diagnostics, University Hospital in Bia\u0142ystok, Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Brandner","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Universit\u00e4tsklinikum Erlangen, and Friedrich-Alexander Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"Maler","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Universit\u00e4tsklinikum Erlangen, and Friedrich-Alexander Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Oberstein","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Universit\u00e4tsklinikum Erlangen, and Friedrich-Alexander Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Szmitkowski","sequence":"additional","affiliation":[{"name":"Department of Biochemical Diagnostics, Medical University of Bia\u0142ystok, Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Rauh","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Universit\u00e4tsklinikum Erlangen, and Friedrich-Alexander Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Kornhuber","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Universit\u00e4tsklinikum Erlangen, and Friedrich-Alexander Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Lewczuk","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Universit\u00e4tsklinikum Erlangen, and Friedrich-Alexander Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,5,19]]},"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-132687","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-132687","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:00:23Z","timestamp":1777370423000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-132687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,19]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,5,19]]}},"alternative-id":["10.3233\/JAD-132687"],"URL":"https:\/\/doi.org\/10.3233\/jad-132687","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,19]]}}}